University of Kansas Department of Molecular Biosciences Center for Bioinformatics 2030 Becker Dr Lawrence, KS 66047-1620 Phone: (785)864-1948 fax: (785)864-5558 Email: Zhanglab@ku.edu Research Interests Protein structure prediction Ligand-protein docking Protein-protein interactions Structure and function of G protein-coupled receptors New drug design

Determining structure and function of protein molecules is a cornerstone of many aspects of modern biology and medicine. The main focus of our lab is to develop bioinformatics algorithms to predict the 3-dimensional structures of proteins from amino acid sequences and then deduce the biological functions based on the sequence-to-structure-to-function paradigm. We are also working on the modeling of ligand-protein and protein-protein interactions. We are especially interested in the structures of G protein-coupled receptors (GPCR) and the interactions with the associated ligands with the purpose of developing new drugs to regulate these interactions.