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Note: The I-TASSER Server has been moved to
http://zhanglab.ccmb.med.umich.edu/I-TASSER.
Please use the new website to submit your sequences. The server at this website
website no longer accepts new submission.
All the sequences previously submitted to this server will keep running till completed.

(The server has completed structure and function predictions for
31817
proteins submitted by
7127 users from
83
countries) (Number of visitors: 174191)
I-TASSER is an Internet service for protein structure and function
predictions. Models are built based on multiple-threading alignments
by LOMETS and iterative TASSER simulations.
I-TASSER (as 'Zhang-Server')
was ranked as the No 1 server in recent CASP7 and CASP8 experiments.
The server is in active development with
the goal to provide accurate structural and function predictions
using state-of-the-art algorithms.
The server is only for non-commercial use.
Please send your questions and comments to zhanglab@ku.edu.
(More about
the server ...)
[Queue]
[Search]
[About]
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[Decoys]
[What's new]
I-TASSER News (since January, 2009):
- 2010/01/12:
The I-TASSER server was moved from the University of Kansas to
the University of Michigan Medical School. The new supercomputer cluster at
UM provides significant help in speeding up the modeling procedure of the
I-TASSER server.
- 2009/11/15:
Molecular Dynamic simulations were implemented on
I-TASSER models for removing steric clashes of side-chain atoms
and for further refining rotamer conformations.
- 2009/10/17: A timer was added to the
Queue page to allow users track the implementation time of their
targets. A number of other changes were made in the Queue page for
improving the efficiency of retrieving I-TASSER output data.
- 2009/10/15: A new interface
Search
was added to allow users to search targets
and predictions through the I-TASSER database.
- 2009/07/20: Added features to allow users to assign external
restraints
to guide the I-TASSER structural modeling. The user-specified information
includes:
- Residue-residue contact/distance information
- Specific template structures and alignments
More details can be found at
How to Add Restraints to I-TASSER Modeling.
- 2009/03/16: Structure-based function predictions were developed
based on the global and local match of the predicted 3D models with
the known homolog and analog proteins. The function predictions
include ligand binding site, enzyme commission, and gene ontology.
- 2009/01/10: Two new predictions were added in
the output page:
- Threading templates and the alignments which were
identified by LOMETS
and used by I-TASSER as initial input.
- Structural homologs of I-TASSER which are identified by structural
alignment program
TM-align
through the PDB library.
References:
Yang Zhang.
I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, vol 9, 40 (2008).
(download the PDF file).
Yang Zhang.
Template-based modeling and free modeling by I-TASSER in CASP7.
Proteins, Suppl vol 8, 108-117 (2007)
(download the PDF file).
Sitao Wu, Jeffrey Skolnick, Yang Zhang.
Ab initio modeling of small proteins by iterative TASSER simulations.
BMC Biology, vol 5, 17 (2007).
(download the PDF file).
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