I-TASSER server for protein structure prediction

(The server has completed structure and function predictions for 28906 proteins submitted by 6086 users from 82 countries)
(Number of visitors: 156025)

I-TASSER is an Internet service for protein structure and function predictions. Models are built based on multiple-threading alignments by LOMETS and iterative TASSER simulations. I-TASSER (as 'Zhang-Server') was ranked as the No 1 server in recent CASP7 and CASP8 experiments. The server is in active development with the goal to provide accurate structural and function predictions using state-of-the-art algorithms. The server is only for non-commercial use. Please send your questions and comments to zhanglab@ku.edu. (More about the server ...)

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If you need quicker responses, please submit your sequences to:

LOMETS

MUSTER

Copy and paste your sequence here (<1,500 residues):

Or upload the sequence from your local computer:

Email: (mandatory, where results will be sent to)

ID: (optional, your given name of the protein)

As an option, you can assign additional restraints & templates to guide I-TASSER modeling (More explanation on how to add restraints)

Assign contact/distance restraints
Atom-atom restraints; Explanation

Specify template without alignment
Type a PDBID; Explanation

Specify template without alignment
Upload a structure Explanation

Specify template with alignment
Template & alignment; Explanation

References:

Yang Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, vol 9, 40 (2008). (download the PDF file).
Yang Zhang. Template-based modeling and free modeling by I-TASSER in CASP7. Proteins, Suppl vol 8, 108-117 (2007) (download the PDF file).
Sitao Wu, Jeffrey Skolnick, Yang Zhang. Ab initio modeling of small proteins by iterative TASSER simulations. BMC Biology, vol 5, 17 (2007). (download the PDF file).