I-TASSER results for job id S34198

Submitted Sequence

>Bovine_fetuin_mature IPLDPVAGYKEPACDDPDTEQAALAAVDYINKHLPRGYKHTLNQIDSVKVWPRRPTGEVY DIEIDTLETTCHVLDPTPLANCSVRQQTQHAVEGDCDIHVLKQDGQFSVLFTKCDSSPDS AEDVRKLCPDCPLLAPLNDSRVVHAVEVALATFNAESNGSYLQLVEISRAQFVPLPVSVS VEFAVAATDCIAKEVVDPTKCNLLAEKQYGFCKGSVIQKALGGEDVRVTCTLFQTQPVIP QPQPDGAEAEAPSAVPDAAGPTPSAAGPPVASVVVGPSVVAVPLPLHRAHYDLRHTFSGV ASVESSSGEAFHVGKTPIVGQPSIPGGPVRLCPGRIRYFKI

Predicted Secondary Structure

Sequence	20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                    |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |   IPLDPVAGYKEPACDDPDTEQAALAAVDYINKHLPRGYKHTLNQIDSVKVWPRRPTGEVYDIEIDTLETTCHVLDPTPLANCSVRQQTQHAVEGDCDIHVLKQDGQFSVLFTKCDSSPDSAEDVRKLCPDCPLLAPLNDSRVVHAVEVALATFNAESNGSYLQLVEISRAQFVPLPVSVSVEFAVAATDCIAKEVVDPTKCNLLAEKQYGFCKGSVIQKALGGEDVRVTCTLFQTQPVIPQPQPDGAEAEAPSAVPDAAGPTPSAAGPPVASVVVGPSVVAVPLPLHRAHYDLRHTFSGVASVESSSGEAFHVGKTPIVGQPSIPGGPVRLCPGRIRYFKI
Prediction	CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCSSSSSSSSSSSSSSSCCCCSSSSSSSSSSSCCCCCCCCCCHHHCCCCCCCCCCSSSSCSSSSSSCCCSSSSSSSSCSSSSCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCSSSSSSSSSSSSCCCCSSSSSSSSSSCCCCCCCCCCHHHCCCCCCCCSSSSSSSSSCCCCCCCCSSSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	98588343300799987999999999999865266441699998889999686699469999997641346774897064387466667867987089998248838998776026877888974008798811798877799999999999872378874799999999984378648999999843676024587132578886855788989821688887058873787898755689998778899878977887775557887632367988788899877676567666568886568887667889889877857788999989975225009

Top 5 Models predicted by I-TASSER

Top 10 templates used by I-TASSER

Rank	PDB Hit	Iden1	Iden2	Cov.	Norm. Z-score	Download Align.		20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                    |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |
							Sec.Str Seq	CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCSSSSSSSSSSSSSSSCCCCSSSSSSSSSSSCCCCCCCCCCHHHCCCCCCCCCCSSSSCSSSSSSCCCSSSSSSSSCSSSSCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCSSSSSSSSSSSSCCCCSSSSSSSSSSCCCCCCCCCCHHHCCCCCCCCSSSSSSSSSCCCCCCCCSSSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IPLDPVAGYKEPACDDPDTEQAALAAVDYINKHLPRGYKHTLNQIDSVKVWPRRPTGEVYDIEIDTLETTCHVLDPTPLANCSVRQQTQHAVEGDCDIHVLKQDGQFSVLFTKCDSSPDSAEDVRKLCPDCPLLAPLNDSRVVHAVEVALATFNAESNGSYLQLVEISRAQFVPLPVSVSVEFAVAATDCIAKEVVDPTKCNLLAEKQYGFCKGSVIQKALGGEDVRVTCTLFQTQPVIPQPQPDGAEAEAPSAVPDAAGPTPSAAGPPVASVVVGPSVVAVPLPLHRAHYDLRHTFSGVASVESSSGEAFHVGKTPIVGQPSIPGGPVRLCPGRIRYFKI
1	1zlgA	0.11	0.21	0.96	0.76	Download		GFTAPSKHFRSSK---DPSAPPAPANLRLANSTVNSDGSVTV-TIV---DLPEEPDIPVYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSVILEK-VVELQLKSAKVSLHFTSTHATNNKEQLVKTRKGGIQTQLPFQRRRPTRPLEVGAPFYQDGQLQVKVYWKKTED----PTVNRYHVRWFPEACAHNRTTGSEASSGMTHENYII-SCKYKVTVQPIRPKSHSAEAVFFTTPPCSALKGKSHKPIGCLGEAGHVLSKVLAKPENLSASFIVQDVNITGHFSWKMAKANLYQPMTGFQVTWAEVTTESRQNSLPNSIISQSQILPSDHYPSTLYRLEV
2	2ch9A	0.19	0.10	0.34	3.74	Download		-----------------------------------------------------------------------------------------------------------------------SQDLNSRVKPGFPKTIKTNDPGVLQAARYSVEKFNNCTNDFLFKESRITRALVQIVGLKYMLEVEIGRTTCKKNQHLRLDDCDFQTNKQTLSCYSEVWVVPWLQHFPVLRCHHHHHH---------------------------------------------------------------------------------------------------------
3	2ch9A	0.18	0.10	0.35	2.02	Download		----------------------------------------------------------------------------------------------------------------TC-----SQDLNSRVKPGFPKTIKTNDPGVLQAARYSVEKFNNCTNDMFFKESRITRALVIVKGLKYMLEVEIGRTTCKKNQHLRLDDCDFQTNHTTLSCYSEVWVVPWLQEVPVLRCHHHHHH---------------------------------------------------------------------------------------------------------
4	1w0rA	0.07	0.18	0.99	1.72	Download		DPVLCFTQVEDCCLNTAFAYQKRSGGLCQPCRSPRWSEGSQLRYRWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSPGLAYEQRRCTGLPPCPVAGGTMEQATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEE---EL
5	2ch9A	0.16	0.10	0.35	1.89	Download		---------------------------------------------------------------------------------------------------------------------TCSQDLNSRVKPGFPKTIKTNDPGVLQAARYSVEKFNNCTNDMFFKESRITRALVQIKGLKYMLEVEIGRTTCKKNQHLRLDDCDFQTNHTTLSCYSEVWVVPWLQHFEVPVLRCHHHHHH-------------------------------------------------------------------------------------------------------
6	2ch9A	0.19	0.10	0.35	3.44	Download		NSRVKPGFPKTIKTNDPGVLQAARYSVEKFNNCTNDMFLFKESRI--TRALVQIVKGLKYMLEVEIGRTTCKKNQHLRLDDCDFQTNHTLKQTLSCYSEVWVVPWHFEVPVLRCHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7	1cewI	0.20	0.07	0.31	2.07	Download		------GAPVPVDENDEGLQRALQFAMAEYNRASNDKYSSRVVRVISAKRQL--VSGIKYILQVEIGRTTCPK-SSGDLQSCEFHDEPEMAKYTTCTFVVYSLN-QIKLLESKCQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8	2ch9A	0.20	0.10	0.33	4.10	Download		-----------------------------------------------------------------------------------------------------------------------SQDLNSRVKPGFPKTIKTNDPGVLQAARYSVEKFNNCTNDMFFKESRITRALQIVKGLKYMLEVEIGRTTCKKNQHLRLDDCDFQTNKQTLSCYSEVWVVPWLQHFPVLRCH--------------------------------------------------------------------------------------------------------------
9	2ch9A	0.18	0.10	0.35	1.71	Download		----------------------------------------------------------------------------------------------------------------TC-----SQDLNSRVKPGFPKTIKTNDPGVLQAARYSVEKFNNCTNDMLFKESRITRALVIVKGLKYMLEVEIGRTTCKKNQHLRLDDCDFQTNHTTLSCYSEVWVVPWLQEVPVLRCHHHHHH---------------------------------------------------------------------------------------------------------
10	1w0rA	0.08	0.18	0.93	0.73	Download		CCLNTAFAYQKRSCRSPRWSLWSTWA-----VTCSEGS-----QLRYRRCVGWNGQCS---------GKVAPGTLEWQLQACEDQQCCPEMGGEPCSVT----SKGTRTRRRACNHPAPKQAQESEACTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQ
(a) All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used) (b) Rank of templates represents the top ten threading templates used by I-TASSER. (c) Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence. (d) Ident2 is the percentage sequence identity of the whole template chains with query sequence. (e) Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein. (f) Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa. (g) Download Align. provides the 3D structure of the aligned regions of the threading templates. (h) The top 10 alignments reported above (in order of their ranking) are from the following threading programs:         1: MUSTER   2: HHSEARCH   3: SP3   4: PROSPECT2   5: PPA-I   6: HHSEARCH I   7: FUGUE   8: HHSEARCH II   9: SPARKS   10: MUSTER

10 proteins in PDB which are structurally closest to the first I-TASSER model (identified by TM-align)

Rank TM-score RMSDa IDENa Cov. PDB Hit 1 0.9161 2.01 0.10 0.97 1zlgA Model1   2 0.4370 5.54 0.04 0.64 1yq2A Model1   3 0.4120 5.84 0.03 0.62 1jz8A Model1   4 0.3808 5.67 0.04 0.56 2wb7A Model1   5 0.3746 6.55 0.03 0.63 1epwA Model1   6 0.3708 5.60 0.05 0.56 3cu7A Model1   7 0.3707 6.69 0.06 0.62 1ug9A Model1   8 0.3700 5.47 0.04 0.55 1hzhH Model1   9 0.3696 6.19 0.06 0.59 1i50A Model1   10 0.3695 5.36 0.04 0.54 2a73A Model1

Structural alignment using TM-align   AAGPGAAAARRLDESLSAGSVQRARCASRCLSLQITRISAFFQHFQNNGSLVWCQNHKQCSKCLEPCKESGDLRKHQCQSFCEPLFPKKSYECLTSCEFLKYILLVKQGDCPAPEKASGFAAACVESCEVDNECSGVKKCCSNGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRS-S--KDPSAPPAPANLRLANSTVNSDGSVTVTI---VWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSVILEKLQPDCDYVVELQAITYWGQTRLKSAKVSLHFTSTHATNNKEQLVKTRKGGIQTQLPFQRRRPTRPLEVGAPFYQDGQLQVKVYWKKTED-P---TVNRYHVRWFPEACAHNRTTGSEASSGMTHENYIILQDLSFSCKYKVTVQPIRPKSHSKAEAVFFTTPPCSALKGKSHKPIGCLGEAGHVLSKVLAKPENLSASFIVQDVNITGHFSWKMAKANLYQPMTGFQVTWAEVTTESRQNSLPNSIISQSQILPSDHYVLTVPNLRPSTLYRLEVQVLTPGGEGPATIKTFRTPELPPSSAHRSHLKHRHPHHYKPSPERYGKPIPNPLLGLDSTRTGHHHHHH  ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPLDPVAGYKEPACDDPDTEQAALAAVDYINKHLPRGYKHTLNQIDSVKVWPRRPTGEV-YDIEIDT-LETTCHVLDPTPLANCSVRQQTQHAVEG-D-----CDIHVLK---------QDGQFSVLFTKCDSSPDSAEDVRKLCPDCPLLAPLNDSRVVHAVEVALATFNAESNGSYLQLVEISRAQFVPLPVSVSVEFAVAATDCIAKEVVDPTKCNLLAEKQYGF-C----KGSVIQKALGGEDVR-VTCTLFQTQPVIPQPQPDGAEAEAPSAVPDAAGPTPSAAGPPVASVVVGPSVVAVPLPLHRAHYDLRHTFSGVASVESSSGEAFHVGKTPIVGQPSIPGGPVRLCPGRIR-Y-----FKI-----------------------------------------------------------------------    ADVSYLTDQGPGSGRRVPARSWLHSDAPALSLNGDWRFRLLPAAPGTAGAGSVLPSGETVEGVAAESYDDAAWDTLPVPSHWVMGQDGKYGRPIYTNVQYPFPIDPPHVPDANPTGDFRRRFDVPAQWFESTTAALTLRFDGVESRYKVWVNGQEIGVGSGSRLAQEFDVSDALRAGSNLLVVRVHQWSAASYLEDQDQWWLPGIFRDVTLQARPAGGITDAWLRTGWSARSGAGTGTIDPEITADATAFPVTLSVPELGVNVTWKSAEEVAPLALENVEPWSAEVPRLYEASVSSAAESISVRLGFRTVR----------------------IVGDQFLVNGRRVVFHGVNRHETHPDRGRVFDEAGAREDLALMKRFNVNAIRTSHYPPHPRLLDLADEMGFW--------------------VILECDLETHGFEAGGWVENPSDVPAWRDALVDRME-RTVERDKNH-----------PSIVMWSLGNESGTGSNLAAMAAWAHARDSSRPVHYEGDYTGAYTDVYSRMYSSIPETDSIGRNDSHALLLGCDSAESARQRTKPFILCEYV-H-AMGN-GP-GAMDQYEALVDKYPRLHGGFVWEWRDHGIRTRTAEGMEFFAYGGDFGEVVHDSNFVMDGMVLSDSTPTPGLYEFKQIVSPIRLGLSLPAGG---------KPTLAVANLRHTADASDVVLRWRVEHDGA-VAASGEVAAEGSDGPLRAGESATIALPAMPAAPLGETWLTVEAVLRDATGWAPAGHPL-GAVQLDLSA--PAVPTR----SPRPATPLDGALPVSLGPATFDAGTLVSL---------------AGQPVSGPRLELWRAPTDNDRGAGFGAYGPGDPWLNSGRGVPAPSSEAVWKQAGLDRLTRRVEDVAALPDGIRVRTRYAAADSTHSVAVEENWQLDGGELCLRIDITPSAGWNLVWPRIGVRWDLPTDVDGAAWFGAGPRESYPDSMHATMVARHAASLEELNVPYARPQETGHRSDVRWLEL------------------------DRAGAPWLRIDAEPDAAGRRPGFSLARHTAQEIAAAGHPHELPTPSHSYLYVDAAQHGLGSRACGPDVWPDFALRPEARTLKLRISPA----------  -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPLDPVAGYKEPACDDPDTEQAALAAVDY-----INK-HL---------------------PRGY----K-HTL--------------------NQIDSVKVWPRRPTGEVYDIEIDTLETT-------------------------C--HVL--DPTPLANCSVRQQTQHAVEGDCDI-------------H--VLKQDG-QFSVLF-----------T-K-----------------------------------CDSSPDSAEDVR-KLCPDCP-LL--A------PLND---------------------------------------------------------SR---VVHAVEVALATFNAESNGSYLQLVEISRAQFVPLP-VSVSVEFAVAATDCIAKEVVDPT--KCNL-----LAEKQYGFCK-----GSVIQKALGG--E--D--VRVTCTLFQTQPVIPQPQPDGAEAEAPSAVPDAA-------G----PTPSAAGPPVASVVVGPSVVAVPLPLHRAHYD------------------------------------------------------------------------------------------------------------------LRHTFS-------------------------------------------------------GVASVESSSGEAFHVGKTPIVGQPSI--PGGP-----------------------------------------------------------------------------VRLCPGRIRYFKI    RRDWENPGVTQLNRLAAHPPFASWRNSEEARTDRPSQQLRSLNGEWRFAWFPAPEAVPESWLECDLPEADTVVVPSNWQMHGYDAPIYTNVTYPITVNPPFVPTENPTGCYSLTFNVDESWLQEGQTRIIFDGVNSAFHLWCNGRWVGYGQDSRLPSEFDLSAFLRAGENRLAVMVLRWSDGSYLEDQDMWRMSGIFRDVSLLHKPTTQISDFHVAT---------RF-NDDFSRAVLEAEVQMCGELRDYLRVTVSLWQGETQVASGTAPFGGEIIDERGGYADRVTLRLNVENPKLWSAEIPNLYRAVVELHTADGTLIEAEACDVGFR-----EVR--IENGLLLLNGKPLLIRGVNRHEHHPLHGQVMDEQTMVQDILLMKQNNFNAVRCSHYPNHPLWYTLCDRYGLY------------------VVDEANIETHGMVPMNRLTDDPRWLPAMSE-RVT-RMVQRDRNH----------PSVIIWSLGNESGHGANHDALYRWIKSVDPSRPVQYEGGGADTTATDIICPMYARVDEDQPFPAVPKWSIKKWLSLPGETRPLILCQYAHAMGNSLG--GFAKYWQAFRQYPRLQGGFVWDWVDQSLIKYDENGNPWSAYGGDFGDTPNDRQFCMNGLVFADRTPHPALTEAKHQQQFFQFRLSG-------------QTIEVTSEYLFRHSDNELLHWMVALDGK-PLASGEVPLD-VAPQGKQLIELPELPQPESAGQLWLTVRVVQPNATAWSEAGHISAWQQWRLAE---NLSVTLPAASHAIPHLTTSE-----------------MDFCIEL-G-----------NKRWQFNRQSGFLSQMWIGDKKQLLTPLRDQFTRAPLDNDIGVSEATRIDPNAWVERWKAAGHYQAEAALLQCTADTLADAVLITTAHAWQHQGKTLFISRKTYRIDGSGQMAITVDVEVASDTPHPARIGLNCQ---------------------LAQVAERVNWLGLGPQENYPDRLTAACFDRWDLPLSDMYTPYVFPSENGLRCGTRELNYGPHQWRGDFQFNISRYSQQQLMETSHRHLLHAEEGTWLNIDGFHMGIGGDDSWSPSVSAEFQLSAGRYHYQLVWCQK-----------  -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPLDPVAGYK-EPAC---------------------------------------------------------------------------------------------------DDPDTE--QAALAAVDY-----I-NKHL---------------------P-RG--Y-K-HTLN-------------------QIDSVKVWPRRPTGEVYDIEIDTLETT---------------------CH--VLD--PTPLANCSVRQQTQHAVEGDCDI-------------H--VLKQDG-QFSVLF------------T-K-------------------------------CDSSPDSAEDVRKLCPDCPLL--A------PLND---------------------------------------------------------SR--VVHAVEVALATFNAESNGSYLQLVEISRAQFVPL-PVSVSVEFAVAATDCIAKEVVDPTKCN---LLAEKQYGFC-K-----GSVIQKALG-G-E--D--VRVTCTLFQTQPVIPQPQPDG---------------AEAEAPSAVPDAAGPTPSAAGPPVASVVVGPSVVAVPLPLHRAH----YDLRH------TFSGV------------------------------------------------------------------------------------------------------------ASVESSSGEAFHVGKTPIVGQPSI---------------------------------------------------------PGG----------------------------------------------------------------------PVRLCPGRIRYFKI    NATINDDDIDDVKKALDHATQAAHKAAAELTAKLRSDFVEYGNGGTAG----------------------QVLIHIYGPGLIYGFSA-----------FPVQIRLEIPNQPVPFNKVHITEVTAYVIDENNRTYWTR--------VWNSSTFRQGGYIADTLDLVTVKAPDPLVYQIRDAIVTGQISRELYDKIWNTSTTHFEIRVIVKGYQEAWKTDSSVSNQSSCPSDGHWYEDACWVHDKDIDFTLKAE-TT--------------------TAWGHVTGTNDVATIDGGLGSLPIKFLQSLDLSGKWVLYQNKYAGALSDFIIITAASPVHVL--NSTA-YKFLITPNPGYFQPANPKISDEYRFVTLRVIEGGRELADTTTGHIGDLTEPTFFGLTAHYTDAPGTLDYHALGLVYAYVERDDGVKIPIWLAAEPISVLSNTYTVKDQDVKNLIDLYKKKDREKINATTKAINSLQEKIDEAEQLLAKAKGNNENAIEYAQGAIDEYKAAINDLQKAAQQDDYQFLNYLNAAKKHEAGDYYVNAARKALNGDLEQAKIDAEKAKEYSNLAKEYEP------------------------------------------------------------------------------------  ------------------------------------------------IPLDPVAGYKEPACDDPDTEQAALAAVDYIN--------KHLPRGYKHTLNQIDSVKVWPRR-PTG-EVYDIEIDT-------------LETTCHVLDPTPLANCSVRQ---QTQHAVE-----------------------------------GDCDIHVLKQD-------------------------------G-QFSVLFTKCDSSPDSAEDVRKLCPDCPLLAPL-NDSR-V--VH-------------------------AV------------EVALATF--NAESNGSYLQLVEIS--RA--QFVPLPVSVSVEFAVAA---TDCIAKEVVDPTKCNLLAEKQYGFCK--------GSVIQKALGGED-----VRVTCTLFQTQPVIPQPQ----------------------------------PDGAEAEAPS-AVPD-----------------------------------------------------------------------------------AAGPTPSAAGPPVASVVVGPSVVAVPLPLHRAHYDLRHTFSGVASVESSSGEAFHVGKTPIVGQPSIPGGPVRLCPGRIRYFKI    PVTINNFNYNDPIDNNNIIMMEPPFARGTGRYYKAFKITDRIWIIPERYTFGYKPEDFNKSSGIFNRDVCEYYDPDYLNTNDKKNIFLQTMIKLFNRIKSKPLGEKLLEMIINGIPYLGDRRVPLEEFNTNIASVTVNKLISNPGEVERKKGIFANLIIFGPGPVLNENETIDIGIQNHFASREGFGGIMQMKFCPEYVSVFNNVQENKGASIFNRRGYFSDPALILMHELIHVLHGLYGIKVDDLPIVPNEKKFFMQSTDAIQAEELYTFGGQDPSIITPSTDKSIYDKVLQNFRGIVDRLNKVLVCISDPNININIYKNKFKDKYKFVEDSEGKYSIDVESFDKLYKSLMFGFTETNIAENYKIKTRASYFSDSLPPVKIKNLLDNEIYTIEEGFNISDKDMEKEYRGQNKAINKQAYEEISKEHLAVYKIQMCKSVGICIDVDNEDLFFIADKNSFSDDLSKNERIEYNTQSNYIENDFPINELILDTDLISKIELPSENTESLTDFNVDVPVYEKQPAIKKIFTDENTIFQYLYSQTFPLDIRDISLTSSFDDALLFSNKVYSFFSMDYIKTANKVVEAGLFAGWVKQIVNDFVIEANKSNTMDKIADISLIVPYIGLALNVGNETAKGNFENAFEIAGASILLEFIPELLIPVVGAFLLESYIDNKNKIIKTIDNALTKRNEKWSDMYGLIVAQWLSTVNTQFYTIKEGMYKALNYQAQALEEIIKYRYNIYSEKEKSNINIDFNDINSKLNEGINQAIDNINNFINGCSVSYLMKKMIPLAVEKLLDFDNTLKKNLLNYIDENKLYLIGSAEYEKSKVNKYLKTIMPFDLSIYTNDTILIEMFNKYNSEILNNIILNLRYKDNNLIDLSGYGAKVEVYDGVELNDKNQFKLTSSANSKIRVTQNQNIIFNSVFLDFSVSFWIRIPKYKNDGIQNYIHN------------EYTII-NCMKNNSGWKISIRG-------------NRIIWTLIDING--KTKSVFFEYNIREDISEYINRWFFVTITNN--------LNN-A----------KIYINGKLESNTDIKDIREVIANGEIIFKLDGDIDRTQFIWMKYFSIFNTELSQSNIEERYK-----IQ--SYSEYLKDF----WGNPLMYNKEY----------------YM-FNAG---------NKNSYIKLKKD--SPVGEILTRSKYNQNSKYINYRDLYIGEK-FIIRRKSNSQSINDDIVRKEDYI------------------YLDFFNLNQEWRVYTYKYFKKEEEKLFLAPISDSDEFYNTIQIKEYDEQPTYSCQLLFKKDEE----------------------------------------------STDEIGLIGIHRFYESGIVFEEYKDYFCISKWYLKEVKRKPYNLKLGCNWQFIPKDEGWTE-----------------------------------------------  --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPLDPVAGYKEPACDD-PDTEQAALAAVDYI--NKHLPRGYKHTLNQIDSVKVWPRRPTGEVYDI---------------------EIDTLETTCHVLDPTPLANCSVRQQTQHAV---EGDCDIHVL-KQDGQF--------------------------SVLFT-KCDSSPDSAEDVRKLCPDCPLL----APLNDSRVVH--AVEVALATFNAESNGSYLQLVEI---SRAQFVPLPVSVSVEFAV--AATDCIAKEVVDPTKC-----NLLAEKQYGFCKGS--------------------VIQKALGGEDVRVTCTLFQTQP------V----------------IPQPQPDG----------------------------AEAEAPSAVPDAAGPTPSAAGPPVASVVVGPSVVAVPLPLHRAHYDLR-----------------------------------------------------------HTFSGVASVESSSGEAFHVGKTPIVGQPSIPGGPVRLCPGRIRYFKI    EQ----------------------TYVISAPKIFR--------VGASENIVIQVYGYTEAFDATISIKSY----PDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFS-KSKRM-PI---TY-----------------DNGFLFIHTDKPVYTP----DQSVKVRVYSLNDDLKPAKRETVLTFIDPEG-SEV-DMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKED-FSTTGTAYFEVKEYVLPCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILL------QKK-IEEIA-AKYKHSVVKKCCYDGACVNNDETCEQRAARISLGP----------------------------RCIKAFTECCVVASQLRANISLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGIGISNTGICVADTVKAKV---------------------------------------------------  --IPLDPVAGYKEPACDDPDTEQAALAAVDYINKHLPRGYKHTLNQIDSVKVWP-RRPTGEVYDIEIDTLETTCHVLDPT-PLANCSVR------QQTQHAV--E---------GDCDIHVLKQDGQFSVLFTKCDSSPDSAEDVRKLCPDCPLLAPLNDSRVVHAVEVALATFNAESNGSYLQLVEISRAQF-VPLPVSVSVEFAVAATDCIAKEVVDPTKCNLLAEKQYGFC--KG--SVIQKALGGEDVRVTCTLFQTQPVIPQP-------------------------------------------------------------------------------------------------------------QPDGAEAE-APSAVPDAAGP-------------------------------TPSAAGPPVASVVVGPSVVAVPLPLHRAH-------------------------------------------------------------------------------------------YDLRHTFSGVASVESSSGEAFHVGKTPIVGQPSIPGGPVRLCPGRIRYFKI    TAEPPGSPGAAATWTKGDKEGVGTSLNPASKVWYTLTEGTMSEVYYPHADTPNTRELQFAVSDGTSAQRESEQTTRTVELADPKALSYRQTTTDNAGRWRLTKTYVTDPRRSTVMLGVTFEVLDGGDYQLFVLSDPSLAGTSGGDTGSVTDGALLASDLADAATPVATALVSSVGFGAVANGYVGTSDGWTDLAADGRLDNASATAGPGNISQTGQIPLAAGGKTEFSLALGFGADTAEALATAKASLGTGYKKVSKSYTGEWKKYL---------NSLDAPATSLTGAL--RTQYDV----------------------SLMTV------KSHEDKTFPGAFIASLTIPWGQAASAETHREGYHAVWARDMYQS--VTA-LLA-AGDEEAAARGVEWLFTYQQQPDGHFPQTSRVDGTIG----------------QNGIQLDETAFPILLANQIGRTDAGFYRNELKPAADYLVAAGPKTPQERWEET--GGYSTSTLASQIA-----------------------ALAAAADIAGKNGDAGSAAVYRATADEWQRSTEKWMFTTNGPVGDGKYYLRISATGNPNDGATRDWGNGAGVHPENAVLDGGFLEFVRLGVKAPADPYVADSLAETDASISQETPGGRMWHRYTYDGYGEKADGSPWDGTGIGRLWPLLSGERGEYALANGQDALPYLETMHSAANAGYMIPEQVWDRDEPTSYGHELGRSTGSASPLSWAMAQYVRLAAGVKAGAPVETPQNVAARYAAGTPLSSPELSVTAPEALSTADSATAVVRGTTNAAKVYVSVNGTAT-------EAPVTDGTFSLDVALTGAKNK---VTVAAVAADGG----------TAVEDRTVLYYGSRIGALSDPAG-----------------------------DD-N----------------GPGTYRYPTNSAYVPGAFDLTGVDVYDAGDDYAFVATIAGEVTNPWGGQAISHQRVNIYLGKGEGGATPGLPGTNINLEHAWDSVIVTDGRFDGAGVYAPDGTRTSAVSLLAVPEARQIVTRVPKAALGGLDPATARMSVAMFGNAESGEGIGNVRPVYDGAYWEAGDPAWIKEWRFGGGAGVFDGTIPSRD------------TDTDDPNALDVLVGEGQTQAAVLDWRAGSPVVVPMLGLQP  ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPLDPVAGYKEPACDDPDT----EQAALAAVDYINKHLPRGYKHTLNQIDSVKVWPR-RPTGEVYDIE-------ID-T-LE-------T-TCHV--LDP--------TPL--ANC-SVRQQTQH--AV--E---G---------DCDI-----HVLKQDGQFSVLFTKCDSSPDS--------------------------------------AEDV-RKLCPDCPLLAPLNDSRVVHAVEVALATFNAESNGSYLQLVEISRAQFVPLP---V-S--VS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-EFAVAA-TDC----IAKE-------VVD-------PTKCNLLAEKQY--GFC-----------KGSVIQKA------LGGEDVRVTCTLFQTQ-----------------PVIPQPQPDGAEAEAPSAVPDAAGPTPSAA-GPPVASVVVGPSVVAVPLPLHRAHY-D-----LRHT-----------------------------------------------------------------------------------------------------------------------------F-----------SGVA--------------------SVE----------SSSGEAFHVGKTPIV-GQPSIPGGPV---RL-CPGRIRYFKI----------    QVQLVQSGAEVKKPGASVKVSCQASGYRFSNFVIHWVRQAPGQRFEWMGWINPYNGNKEFSAKFQDRVTFTADTSANTAYMELRSLRSADTAVYYCARVGPYSWDDSPQDNYYMDVWGKGTTVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKAEPKSCDKTHTCPPCPAP----EL--LGGPSVFLFPPKPKDTLMISRTPEVTC---VVVD-VS-HEDPEVKFNWYVDGV-EVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA---K--------G--QPRE------PQVYTLPPSRDELTKN--------QVSLTCLVKGFYPS-DIAV---E-WES------------NGQPENNYKTTPPVLDSDGSFFLYSK---LTVDKSRWQQG--NVFSCSVMHEALH------NHYTQKSLSLSPGK-----------------------------------------------------------------------------------------------------  ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I-P------------------L--D-P--V-A-GYKEPACDDPDTEQAALAAVDYINK--HL-PRGYKHTLNQIDSVKVWPRRPTGEVYDIEIDTLETTCHVLDPTPLANCSV--RQQTQHAVEGD----------CDIHVLKQ-D-GQFSVLFTKCDSSPDSAEDVRKLCPDCPLLAPLNDSRVVHAVEVALAT---FNAESNGSYLQLVEIS------RAQF-VPLPVSVSVEFAVAATDCIAKEVVDPT-------------------KCNLLAEK-QYGFCKGSVIQKAL------GGEDVRVTCTLFQTQPVIP-QPQPDGAEAEAPSAVPDAAGPTPSAAGPPVASVVVGPSVVAVPLPLHRAHYDLRHTFSGVASVESSSGEAFHVGKTPIVGQPSIPGGPVRLCPGRIRYFKI    VGQQYSSAPLRTVKEVQFGLFSPEEVRAISVAKIRFPETMDETQTRAKIGGLNDPRLGSIDRNLKCQTCQEGMNECPGHFGHIDLAKPVFHVGFIAKIKKVCECVCMHCGKLLLDEHNELMRQALAIKDSKKRFAAIWTLCKTKMVCETDVPSEDDPTQLVSRGGCGNTQPTIRKDGLKLVGSWKKDRATGDADEPELRVLSTEEILNIFKHISVKDFTSLGFNEVFSRPEWMILTCLPVPPPPVRPSISFNESQRGEDDLTFKLADILKANISLETLEHNGAPHHAIEEAESLLQFHVATYMDNDIAGQPQALQKSGRPVKSIRARLKGKEGRIRGNLMGKRVDFSARTVISG----------------------------DPNLELD----QVGVP------------------KS-IAKTL----TYPEVVTPYNIDRLTQLVRNGPNEH-------PGAKYVIRDSGDRIDLRYSKRAGDIQLQYGWKVERHIMDNDPVLFNRQPSLHKMSMMAHRVKV---------IPYSTFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSPQSNKPCMGIV-------QDTLCGIRKLTLRDTFIELDQVLNMLYWVPDWDGVIPTPAIIKPKPLW------------SGKQILSVA----IPNGIHLQRFDEGTTLLSPKD---NGMLIIDG------QIIFGVV----EKKTVGSSNGGLIHVVTREKGPQVCAKLFGNIQKVVNFWLLHNGFSTGIGDTIADGP-------------TMREITETIAEAKKKVLDVTKEAQANLLTAKH----------------GMTLRESFEDNVVRFLNEARDKAGRLAEVNLKDLNNVKQMVMAGSKGSFINIAQMSACVGQQSVEGKRIAFGFVDRTLPHFSKDDYSPESKGFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKTAETGYIQRRLVKALEDIMVHYDNTTRNSLGNVIQFIYGEDGMDAAHIEKQSLDTIGGSDAAFEKRYRVDLLNTDHTLDPSLLESGSEILGDLKLQVLLDEEYKQLVKDRKFLREVFVDGEANWPLPVNIRRIIQNAQQTFHIDHTKPSDLTIKDIVLGVKDLQENLLVLRGKNEIIQNAQRDAVTLFCCLLRSRLATRRVLQEYRLTKQAFDWVLSNIEAQFLRSVVHPGEMVGVLAAQSIGEPATQMTLKKVTSGVPRLKEILNVAKNMKTPSLTVYLEPGHAADQEQAKLIRSAIEHTTLKSVTIASEIYYDPDPRSTVIPEDEEIIQLHFSLQQSPWLLRLELDRAAMNDKDLTMGQVGERIKQTFKNDLFVIWSEDNDEKLIIRCRVVAEEDHMLKKIENTMLENITLRGVENIERVVMMKYDRKVPSPTGEYVKEPEWVLETDGVNLSEVMTVPGIDPTRIYTNSFIDIMEVLGIEAGRAALYKEVYNVIASDGSYVNYRHMALLVDVMTTQGGLTSVTRHGFNRSNTGALMRCSFEETVEILFEAGASAELDDCRGVSENVILGQMAPIGTGAFDVMIDEESL----  ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPLDPVAGYKEPACDDPDTEQAALAAVDYINKHLPRGYKHTLN-QIDSVKVWPRRPTGEVYDI-EIDTLETTCHVLDPT----PLAN------------CSVRQQTQ------------------------------------HAVEGD-----------------CDIHVLKQDGQFSVLFTKCDSSPDSAEDVRKLCPDC--------------------------------------PLLAPLNDSRV-VH--AVEVA----------------------------------LATFNAESNGSYLQLVEISRAQFVPLPV-SVSVEFAVAA-------TDCIAKEVVDPTKCNLLAEKQYG-FCKGSVIQK------AL--G---GED-VRV-TC--TL--F---------------------QTQPVIPQPQPDGAEAEA-PS-AVPDAAGP-TP--S----AAGPPVASVVVGPSVVAVPLPLHR--AH--Y-------------------------------------------------------D---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LRHT-----------------FSG----------------------VASV-----------------------------------------------------E-SSS---G--------------EA------FHV------------------G----KTPIV--GQPSIPGGPV-------------RLCPG-------------RIR--------------------------------------------------------------------------------------------------------------------------------YFKI    SP----------------------MYSIITPNILR---------LESEETMVLEAHDAQGDVPVTVTVHD-----FPGKKLVLSSE-KTVLTPATNHMGNVTFTIPANRERNKFVTVQATFGTQV-VEKV--VLV--S------------------LQSGYLFIQTDKTIYT---PGSTVLYRIFTVNHKLLP--VGRTVMVNIEN-P-EGIPVKQDSLSSQNQLGVLPLSWDIPELVNMGQWKIRAYYENS-PQ-QVFSTEFEVKEYVLPSFEVIVEPTEKFYYIYNEKGLEVTITARFLYGKKVEGTAF--VIFGIQDGEQRISLPESLKRIPIEDGSGEVVLSRKVLLDGVLRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSPYQIHFTKTPKYFKPGMPFDLMVFVTNPDGSPAYRVPVAVQGEDTVQSLTQGDGVAKLSINTHPSQKPLSITVRTKKQELSEAEQATRTMQALPYSTVGNSNNYLHLSVLRTELRPGETLNVNFLLRMDRAHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDLVVLPLSITTDFIPSFRLVAYYTLIGASGQREVVADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKDYAGVFSDAGLTFTSSSGQQTAQRAELQCPQP--------------------------------------------------------------------------------------  --IPLDPVAGYKEPACDDPDTEQAALAAVDYINKHLPRGYKHTLNQIDSVKVWPR--RPTGEVYDIEIDTLETTCHVLDPTPLANCSVRQ---------QTQHAVE------GDCDIHVLKQDGQFSVLFTKCDSSPDSAEDVRKLCPDCPLLAPLNDSRVVHAVEVALATFNAESNGSYLQLVEISRAQ---FVPLPVSVSVEFAVAATDCIAKEVVDPT-KCNLLAEKQYGF---C-KGSVIQKALGGEDVRVTCTLFQTQPVIPQPQP----------------------------------------DGAEAE------APSAV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDAAGPTPSAAGPPVASVVVGPSVVAVPLPLHRAHYDLRHTFSGVASVESSSGEAFHVGKTPIVGQPSIPGGPVRLCPGRIRYFKI

(a)	Residue pairs that are structurally aligned by TM-align program are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade.(more about the colors used)
(b)	Ranking of proteins is based on TM-score of the structural alignment between Model1 and the PDB structures in our template library.
(c)	RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDENa is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the model.

Function Prediction

Predicted EC Numbers

Rank	TM-score	RMSDa	IDENa	Cov.	EC-Score	PDB Hit	EC No.
1	0.3076	6.69	0.10	0.52	0.3271	1ffuB	1.2.99.2
2	0.3432	6.60	0.07	0.57	0.3017	2qtcB	1.2.4.1
3	0.3257	6.31	0.07	0.53	0.2947	2j62A	3.2.1.52
4	0.3656	6.57	0.05	0.61	0.2904	2np0A	3.4.24.69
5	0.2993	6.60	0.08	0.51	0.2880	1h3fB	6.1.1.1

(a)	Ranking is based on EC-score, which is a confidence score for the Enzyme Classification (EC) Number prediction.
(b)	RMSDa is the RMSD between models and the PDB structure in the structurally aligned regions by TM-align.
(c)	IDENa is percentage sequence identity in the structurally aligned region.
(d)	Cov. represents the coverage of the alignment and is equal to the number of structurally aligned residues divided by length of model.
(e)	EC-Score is defined based on the C-score of the structure prediction and similarity of the model with known enzyme structures, as identified using both global and local structural alignment programs. The global similarity score uses TM-score, IDENa,RMSDa and Cov. of the structural alignment by TM-align, while the local match compares the structural and chemical similarity of local spatial motifs in the model with known catalytic site of enzymes. A prediction with a EC-score >1.1 signifies a prediction with high confidence (upto 3 digit numbers of EC) and vice versa (For details, see Ambrish, Kucukural and Zhang,Large scale benchmarking of protein function prediction using predicted protein structures, 2009, submitted).

Predicted GO terms

Rank	TMscore	RMSDa	IDENa	Cov.	PDB Hit	Fh-Score	Associated GO Terms
1	0.9161	2.01	0.10	0.97	1zlgA	0.84	GO:0004867 GO:0005201 GO:0005515 GO:0000904 GO:0006928 GO:0006935 GO:0007005 GO:0007155 GO:0007411 GO:0007626 GO:0009653 GO:0022610 GO:0030030 GO:0040011 GO:0042221 GO:0048468 GO:0048667 GO:0048856 GO:0048858 GO:0070584 GO:0005576 GO:0005578 GO:0005615 GO:0005623 GO:0009986
2	0.3848	5.37	0.10	0.56	2b39B	0.38	GO:0004866 GO:0005515 GO:0002376 GO:0006955 GO:0009987 GO:0044237 GO:0050789 GO:0065007 GO:0005576 GO:0005615
3	0.3407	4.66	0.09	0.47	2zg3A	0.31	GO:0005515 GO:0005529 GO:0007155 GO:0022610 GO:0005622 GO:0005623 GO:0005737 GO:0005783 GO:0016020 GO:0016021 GO:0043229 GO:0044444
4	0.4111	5.69	0.04	0.61	3decA	0.31	GO:0004565 GO:0030246 GO:0043169 GO:0005975 GO:0009341
5	0.3206	6.10	0.09	0.50	1zvoD	0.31	GO:0003823 GO:0002376 GO:0006955 GO:0005576 GO:0005623 GO:0005886 GO:0016021
6	0.4186	5.65	0.04	0.62	1px4D	0.30	GO:0004565 GO:0005515 GO:0030246 GO:0043169 GO:0005975 GO:0009341
7	0.3432	6.60	0.07	0.57	2qtcB	0.30	GO:0000287 GO:0004739 GO:0005515 GO:0016624 GO:0006006 GO:0006066 GO:0006091 GO:0006096 GO:0009056 GO:0009987 GO:0016052 GO:0044260 GO:0044265 GO:0044275 GO:0046164 GO:0055114 GO:0005622 GO:0005623 GO:0005737 GO:0005739 GO:0005829 GO:0043229
8	0.3037	6.85	0.08	0.52	2dy1A	0.30	GO:0003676 GO:0003746 GO:0003924 GO:0005525 GO:0019001
9	0.3781	6.18	0.05	0.61	2vr4B	0.30	GO:0004553 GO:0043169 GO:0005975
10	0.3164	5.15	0.09	0.45	2v2tB	0.30	GO:0003677 GO:0003700 GO:0016566 GO:0042802 GO:0042803 GO:0001816 GO:0002376 GO:0009987 GO:0032502 GO:0044237 GO:0050789 GO:0065007 GO:0005622 GO:0005623 GO:0005634 GO:0005737 GO:0043229

Consensus Prediction of Gene Ontology terms
Molecular Function    Biological Process   Cellular Location GO term GO-Score    GO term GO-Score   GO term GO-Score GO:0005488 0.366    GO:0009987 0.243    GO:0005623 0.264 GO:0005515 0.244    GO:0008152 0.218    GO:0044464 0.264 GO:0003824 0.151    GO:0050896 0.154    GO:0005576 0.183 GO:0004857 0.123    GO:0044238 0.151    GO:0005737 0.149 GO:0030414 0.123    GO:0044237 0.127    GO:0044424 0.149 GO:0004866 0.123    GO:0005975 0.121    GO:0005622 0.149 GO:0030234 0.123    GO:0022610 0.116    GO:0043227 0.149 GO:0016787 0.121    GO:0007155 0.116    GO:0043229 0.149 GO:0043167 0.121    GO:0032502 0.114    GO:0043231 0.149 GO:0030246 0.093    GO:0032501 0.114    GO:0043226 0.149

(a)	Ranking in the first table is based on a function prediction score (Fh-score), which is calculated based on the C-score of the structure prediction and the TM-score, IDENa, RMSDa and Cov. of the structural alignment by TM-align between the predicted model and the PDB structures (For details, see Ambrish, Kucukural and Zhang,Large scale benchmarking of protein function prediction using predicted protein structures, 2009, submitted).
(b)	RMSDa is the RMSD between models and the PDB structure in the structurally aligned regions by TM-align.
(c)	IDENa is the percentage sequence identity in the structurally aligned region.
(d)	Cov. represents the coverage of the alignment and is equal to the number of structurally aligned residues divided by length of model.
(e)	A consensus prediction of GO terms is derived from the structural analogs that have an Fh-score of >=1.0. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on the Fh-score of the template from which the GO term is derived. A prediction with a GO-score >0.5 signifies a prediction with high confidence and vice versa.

Predicted Binding Site

No binding site residues were found in the predicted structure.