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I-TASSER results for job id S34344

  Submitted Sequence

>SSO0389
MNKTLGLILTSVFLLSTLGIITGFVIPTQAANSNDAAIYTIPSVTSVSNTSNIVINLFFN
ATSNSTVGAQASAFNYGLAINYTLDAITFTVVLPSGTSYPLIKLNAKNFANYGYYDLAHN
SIVLLLNTTASSTAKELAYSYEQSIGVTPSASYKIYNYTNKTVNVNQYMNELPLSMLIYM
ATNGKYNNLASLPVGTKLEFTYAGVTYIIAVSPTVKLVGELLNPLYTANSKMLPGTNYAV
GRSNITVAVYDNLITTTTSPFNFTLTYSSLAPALIYWFVIANTTYTNNGASTPTASFQAP
PFKQYFPSNSTILYSAAPTKSSILMFNGQMNVTAHENVTLTLQTGTNIYTSPNFNVTPPG
NYTFSGKLGVGFNGFIYQNGSATLTATIFNGTINFFFSSTGQKAAFTFFLVPIVPINLGD
NNGATVIYNGVSLNTGFPQVVVMFNITGNFTKSGSNYLLYGSVYEAELKPLGSTQLQKLA
GATDSTQFVGNLISSASSPLVSYFNYGESTTTITGTSLSFTVLMPLKFIVERLGYIYLVT
FHIWGPSATVTVTGVDYHGTQIALGSFRAYVALPSFYTLPKTPLVGLTCDNMYTLAQVSD
AGSVLETSTANSNANNATVIGPYDLMSNAGLHVAIYNGSKLVKSGNLGLLPNATTAPITT
TITLNGQTVALTYSSAPTAIYPVDFKFEPGFSYSVTTNVIYNTSIPTYVVTVYMPLKYIL
QTKIVMWYVSPDYAAYFYYSSTGQYQTSNVTLTFANVTPELVMPQVFPVGKLYMPFGIND
PYYVFYSSISIGPQSGVIEAVENGFNVGNITSITVELNGMNESIVLSPLNVSKLLISSNL
GEVSQCSPLFTTTLFNISALASLLGLPNAAALNGSYLYVTYHDIISGAYVTNRTLLVVGQ
FYVMPPTTPGSVEWILTAKYINATTGIPVEISYAVVQQPSAKVVDINAANASITQIQVTG
VKIVSKYATVTVMYNPSNASTIVYMNGMFVASYGGNLISSLSETSTFGVYYGAVVNLYVA
TGTLSSPNGTMYVVLGSHKVAVGTANLYTYAGYHFGPYTALPLVSNVTFTVQDPVTHATL
TGQTTLGAFNNTPIRLAPLGVSIPQTAQYKVFYYYSTPLVLSPTSQYIVLSVTSVISYPY
PFYIETVSFLGYNVTTGTPVPGTPAFQTVYSPSLGPGVVLQVPVQSYQFISLSTPSEPHT
VVMFAVPFAGGPAISLYPTFLVYANVTAISS

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840                 860                 880                 900                 920                 940                 960                 980                1000                1020                1040                1060                1080                1100                1120                1140                1160                1180                1200                1220
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |            
MNKTLGLILTSVFLLSTLGIITGFVIPTQAANSNDAAIYTIPSVTSVSNTSNIVINLFFNATSNSTVGAQASAFNYGLAINYTLDAITFTVVLPSGTSYPLIKLNAKNFANYGYYDLAHNSIVLLLNTTASSTAKELAYSYEQSIGVTPSASYKIYNYTNKTVNVNQYMNELPLSMLIYMATNGKYNNLASLPVGTKLEFTYAGVTYIIAVSPTVKLVGELLNPLYTANSKMLPGTNYAVGRSNITVAVYDNLITTTTSPFNFTLTYSSLAPALIYWFVIANTTYTNNGASTPTASFQAPPFKQYFPSNSTILYSAAPTKSSILMFNGQMNVTAHENVTLTLQTGTNIYTSPNFNVTPPGNYTFSGKLGVGFNGFIYQNGSATLTATIFNGTINFFFSSTGQKAAFTFFLVPIVPINLGDNNGATVIYNGVSLNTGFPQVVVMFNITGNFTKSGSNYLLYGSVYEAELKPLGSTQLQKLAGATDSTQFVGNLISSASSPLVSYFNYGESTTTITGTSLSFTVLMPLKFIVERLGYIYLVTFHIWGPSATVTVTGVDYHGTQIALGSFRAYVALPSFYTLPKTPLVGLTCDNMYTLAQVSDAGSVLETSTANSNANNATVIGPYDLMSNAGLHVAIYNGSKLVKSGNLGLLPNATTAPITTTITLNGQTVALTYSSAPTAIYPVDFKFEPGFSYSVTTNVIYNTSIPTYVVTVYMPLKYILQTKIVMWYVSPDYAAYFYYSSTGQYQTSNVTLTFANVTPELVMPQVFPVGKLYMPFGINDPYYVFYSSISIGPQSGVIEAVENGFNVGNITSITVELNGMNESIVLSPLNVSKLLISSNLGEVSQCSPLFTTTLFNISALASLLGLPNAAALNGSYLYVTYHDIISGAYVTNRTLLVVGQFYVMPPTTPGSVEWILTAKYINATTGIPVEISYAVVQQPSAKVVDINAANASITQIQVTGVKIVSKYATVTVMYNPSNASTIVYMNGMFVASYGGNLISSLSETSTFGVYYGAVVNLYVATGTLSSPNGTMYVVLGSHKVAVGTANLYTYAGYHFGPYTALPLVSNVTFTVQDPVTHATLTGQTTLGAFNNTPIRLAPLGVSIPQTAQYKVFYYYSTPLVLSPTSQYIVLSVTSVISYPYPFYIETVSFLGYNVTTGTPVPGTPAFQTVYSPSLGPGVVLQVPVQSYQFISLSTPSEPHTVVMFAVPFAGGPAISLYPTFLVYANVTAISS
PredictionCCCSSHHHHHHHHHHHHHHHSSSSSCCCCCCCCCCCSSSSCCCSSSSCCCCCSSSSSSSCCCCCCCCCCCCCCCCCCSSSSSSSSSSSSSSSSCCCCCCCCSSSCCCCCCCCCCSSCCCCSSSSSSSCCCCCHHHHHHHHHHHCCCCCCCCCSSSSSCCCCSSSHHHHHHHCCHHHSSSSCCCCCCCCSCCCCCCCSSSSSSCCSSSSSSSCCCHHHHHHHHCHHHHCCCCCCCCCCSSSCCCCSSSSSSCCSSSCCCCCCSSSSSSCCCCCCSSSSSSSSSCSSSCCCCCCCCCCCCCCCHHHHCCCCCSSSSSCCCCCCSSSSSCCSSCSSSCCCSSSSSSCCCCSSCCCCCCCCCCCCSSSSCSSCCCCCSSSSCCCCSSSSSSSSCCSSSSSSCCCCCCSSSSSSSSSSSSSSCCCCCCCSSSSCCSSCCCCCCSSSSSSSSCCCCCCCCCCSSSSSSSSHCHCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCSSSCCCCCCCCCCCSSSSCCCCSSSSSSSCCCCSSSSSSSSCCCCCSSSSSSCSCCCCCSSSCCCSSSSSSCCCCCCCCCCCSSSSSSCCHCHCCCCCCCCCCCCCCCCCCHHCCSSSSCHHHHHHCCCSSSSSSCCCCSSSSCCCCCCCCCSSSSSSSSSSSCCCSSSSSSSCCCCCCCCSSSSSCCCSSSSSCCCSSSCSSCCCCCSSSSSSCHHHCCCSSSSSSSCCCSSSSSSSCCCCCSSSSSSSSSSCCCCCSSSSCCCSSHHHSSSCCCCCCCSSCCCCCCSSCCCCSSSSSSSCCCCSCCSSSSSSSSCCSSSSSSSCCCCHHHHHHHCCHHHHCCCCCCCSSSSSSSHHHHHHCCCCCHHHHCCCSSSSSSSSSSCCCSSSSSSSSSSSSSSSSCCCCCCSSSSSSSCCCCCCCCCCCSSSSSSHHCCCCCCSSCHHHHHHSSCCSSSSSSSSSSCCCSSSSSSSCCCCCSSSSSSCCSSSSCCCCCCCHHHHHHHCCSSSSSSSSSSSCCCCSSCCCCSSSSSSCCCSSSCCCCCCSSCCCSSSCCSSSCCCCCCSSSSSSSCCCCCSSSCSSSSSSCCCCCSSSCCCCCCCCCCCCCCCCSSSCCSSSSCCCCCSSSSSSSSSCCCCCCSSSSSSSSSSSSSCCCCCCCCCCSSSSSSCCCCCCCCCCCCSSSSSSSSSSCCCCCCSSSSSSSCCCCCCCCHHCCCCSSSSSSSSSSCC
Conf.Score9722112367999987532436545002245788614897142356326564799998705677620000000133237777861489999914898652088411114434411203661999983454203677654555203667663067774146425377853215653256450267626330355553389986137999993660677776525455245553788633612462699997034550247725899830146202589999520571588788753234895577288885489851788523899856640364052799997376044279853069985135201123200279607833789999655889998157851268999955676520588883799833560679971999998235212477525897667110216555367887647763035665555306663001331565444514414312465147988201346999994112561379997051578241256566676468422215797678885451020127778776788752222114169772886511554899823870688776365887578888899997481799996137774100468731327999325368602626664499998257228569999817874899997157856999998754355631773250283236750312653320325533567104899981300010358999997666999995342055551240165534499840788882277897618973698468789999887514845888788998867996079996799998425111111597687641130754401103311212120799989999778289899966884199999280899707850441354532646999999999408947136975999989917640265315614322677686001562699999346551573057777625572687045752556678754058702199877876899999971068842489999998786212788656531589984567887412201446787335079997599999634578864320731489986676159

  Top 5 Models predicted by I-TASSER

Download Model 1 Download Model 2 Download Model 3 Download Model 4 Download Model 5
C-score=-2.24
 C-score=-2.22
 C-score=-2.16
 C-score=-2.41
 C-score=-2.17
 
Estimated accuracy of Model1: 0.45±0.15 (TM-score)    15.2±3.5Å (RMSD)    (Read more about C-score of generated models)

  Top 10 templates used by I-TASSER

RankPDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840                 860                 880                 900                 920                 940                 960                 980                1000                1020                1040                1060                1080                1100                1120                1140                1160                1180                1200                1220
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Sec.Str
Seq		CCCSSHHHHHHHHHHHHHHHSSSSSCCCCCCCCCCCSSSSCCCSSSSCCCCCSSSSSSSCCCCCCCCCCCCCCCCCCSSSSSSSSSSSSSSSSCCCCCCCCSSSCCCCCCCCCCSSCCCCSSSSSSSCCCCCHHHHHHHHHHHCCCCCCCCCSSSSSCCCCSSSHHHHHHHCCHHHSSSSCCCCCCCCSCCCCCCCSSSSSSCCSSSSSSSCCCHHHHHHHHCHHHHCCCCCCCCCCSSSCCCCSSSSSSCCSSSCCCCCCSSSSSSCCCCCCSSSSSSSSSCSSSCCCCCCCCCCCCCCCHHHHCCCCCSSSSSCCCCCCSSSSSCCSSCSSSCCCSSSSSSCCCCSSCCCCCCCCCCCCSSSSCSSCCCCCSSSSCCCCSSSSSSSSCCSSSSSSCCCCCCSSSSSSSSSSSSSSCCCCCCCSSSSCCSSCCCCCCSSSSSSSSCCCCCCCCCCSSSSSSSSHCHCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCSSSCCCCCCCCCCCSSSSCCCCSSSSSSSCCCCSSSSSSSSCCCCCSSSSSSCSCCCCCSSSCCCSSSSSSCCCCCCCCCCCSSSSSSCCHCHCCCCCCCCCCCCCCCCCCHHCCSSSSCHHHHHHCCCSSSSSSCCCCSSSSCCCCCCCCCSSSSSSSSSSSCCCSSSSSSSCCCCCCCCSSSSSCCCSSSSSCCCSSSCSSCCCCCSSSSSSCHHHCCCSSSSSSSCCCSSSSSSSCCCCCSSSSSSSSSSCCCCCSSSSCCCSSHHHSSSCCCCCCCSSCCCCCCSSCCCCSSSSSSSCCCCSCCSSSSSSSSCCSSSSSSSCCCCHHHHHHHCCHHHHCCCCCCCSSSSSSSHHHHHHCCCCCHHHHCCCSSSSSSSSSSCCCSSSSSSSSSSSSSSSSCCCCCCSSSSSSSCCCCCCCCCCCSSSSSSHHCCCCCCSSCHHHHHHSSCCSSSSSSSSSSCCCSSSSSSSCCCCCSSSSSSCCSSSSCCCCCCCHHHHHHHCCSSSSSSSSSSSCCCCSSCCCCSSSSSSCCCSSSCCCCCCSSCCCSSSCCSSSCCCCCCSSSSSSSCCCCCSSSCSSSSSSCCCCCSSSCCCCCCCCCCCCCCCCSSSCCSSSSCCCCCSSSSSSSSSCCCCCCSSSSSSSSSSSSSCCCCCCCCCCSSSSSSCCCCCCCCCCCCSSSSSSSSSSCCCCCCSSSSSSSCCCCCCCCHHCCCCSSSSSSSSSSCC
MNKTLGLILTSVFLLSTLGIITGFVIPTQAANSNDAAIYTIPSVTSVSNTSNIVINLFFNATSNSTVGAQASAFNYGLAINYTLDAITFTVVLPSGTSYPLIKLNAKNFANYGYYDLAHNSIVLLLNTTASSTAKELAYSYEQSIGVTPSASYKIYNYTNKTVNVNQYMNELPLSMLIYMATNGKYNNLASLPVGTKLEFTYAGVTYIIAVSPTVKLVGELLNPLYTANSKMLPGTNYAVGRSNITVAVYDNLITTTTSPFNFTLTYSSLAPALIYWFVIANTTYTNNGASTPTASFQAPPFKQYFPSNSTILYSAAPTKSSILMFNGQMNVTAHENVTLTLQTGTNIYTSPNFNVTPPGNYTFSGKLGVGFNGFIYQNGSATLTATIFNGTINFFFSSTGQKAAFTFFLVPIVPINLGDNNGATVIYNGVSLNTGFPQVVVMFNITGNFTKSGSNYLLYGSVYEAELKPLGSTQLQKLAGATDSTQFVGNLISSASSPLVSYFNYGESTTTITGTSLSFTVLMPLKFIVERLGYIYLVTFHIWGPSATVTVTGVDYHGTQIALGSFRAYVALPSFYTLPKTPLVGLTCDNMYTLAQVSDAGSVLETSTANSNANNATVIGPYDLMSNAGLHVAIYNGSKLVKSGNLGLLPNATTAPITTTITLNGQTVALTYSSAPTAIYPVDFKFEPGFSYSVTTNVIYNTSIPTYVVTVYMPLKYILQTKIVMWYVSPDYAAYFYYSSTGQYQTSNVTLTFANVTPELVMPQVFPVGKLYMPFGINDPYYVFYSSISIGPQSGVIEAVENGFNVGNITSITVELNGMNESIVLSPLNVSKLLISSNLGEVSQCSPLFTTTLFNISALASLLGLPNAAALNGSYLYVTYHDIISGAYVTNRTLLVVGQFYVMPPTTPGSVEWILTAKYINATTGIPVEISYAVVQQPSAKVVDINAANASITQIQVTGVKIVSKYATVTVMYNPSNASTIVYMNGMFVASYGGNLISSLSETSTFGVYYGAVVNLYVATGTLSSPNGTMYVVLGSHKVAVGTANLYTYAGYHFGPYTALPLVSNVTFTVQDPVTHATLTGQTTLGAFNNTPIRLAPLGVSIPQTAQYKVFYYYSTPLVLSPTSQYIVLSVTSVISYPYPFYIETVSFLGYNVTTGTPVPGTPAFQTVYSPSLGPGVVLQVPVQSYQFISLSTPSEPHTVVMFAVPFAGGPAISLYPTFLVYANVTAISS
12b5lA 0.14 0.18 0.85 1.24Download MSYNYVVTATAV-----NGCVTGHFTSAED------------LNLLIAKNT--RLEIYV-VTAE---GLR-------PVKEVGMYGIAVMELFPKGESKDLLFILTAK---------YNACILEYKQSGESIDIITRAHGNVQDRIGRPSGIIGIIDPECRMIGLRLYDG----LFKVIPLDRDNKELKAFLEELHDVKFLYGCQAPTICF-------------VYQ------DPQGRHVKTYEVSLREKENKGPWKQENVEAEASMVIAVPEPFGGAIIIGQTYHNGDKYLAIAP---PIIKQSTIVCHNRVDP--NGSRYLLGDEGRL-LLLEKE-TVTLK---DLRVELLGETSIAECYLDNGVVFVGSDSQLVKGSYVVAMETFTNGPIVDMC-LERQGQ------GQLVTCSGAFKEGSRIIRNGIGIHIDLPGIKGLWPLRSDPNRETYDTLVLSFV--------GQTRVLMLNG--EEVE------ETELMGFV------DDQQTFFCGNVAHQ---QLIQITS--ASVRLVSQ----EPKALVSEWKEPQAKNIS----VASCNSSQVVVAVGRALYYLQIHP-QELRQISEMEHEITPLGDSNGLSPLCAIGLWT--DIS-ARILKLPSFELLHKEMLGGEIIPRSILMTTF---ESSHYLLCAL--GDGAL-FYFGLNIE---TGLLSDRKKVTLGTPTVLRTFRSLS--TTNVFACSDRP----TVIYSSNHKLVFSNV--NLKEVN-------------YMCPLNSDG---YPDSLALANNSTLTIGTIDEIQKL---HIRTVPLYESPRKICYQEVS-QCFGVLSSRIEVQDTSGGTTALRPSASTQALSSSVSSSKLFSVEVHNLLIIDQHTFEVLHAHQFEYALSLVSCKLGKDPTYFIVGTAMVYEEAEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSMVEFGKLLASINSTVRLYEWTTEKDVRTECNHY-----NNIMALYLK---TKGILVGDLVLLLA----YKPMEGNFEEIARDFN----PNWMSAVEILDDDNFLGAENAFNLFVCQKDSAATTDEERQHEVGLFHLGEFVNVFCHGSLVMQNLGSTP---TQGSVLFGTVN----MIGLVTSLSESWY-NLLLDMQNRLNKVIKSVGKIFWRSFHTERKTEPA--TGFIDGESFLDIS-RPKMQEVVLQYDDGSGMK-REATADDLVVEELTRIH-
21kcwA 0.06 0.15 0.80 3.14Download KEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINSCQNLNHLKAGLQAFFQVQECIRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSFFEQGTTRIGGSYKKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPVPPSASHVAPTETFTYEWTVPKEVGPTNA------------------------------------------------DPVCLAKMYYSAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLL--------LEDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNV---------------ECLTTDHYTGGMKQKYTVNQCRRQSEDSTFYLGERTYYIAAVEV-----EWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKKVV---------------------YRQYTDSTFRVPVERKAEEEHLGILGPQLHAD------------------VGDKVKIIFKNMATRPYIHAHGVQTESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLY-------------------SGLIGPLIVCRRPRRKLEFALLFLVFDENESWYLDDNIKTYSD---------------------------HPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMH-----------------------------------------------------VGDEVNWYLMGMGNEIDLHT---VHFHGHSFQYKHRGVYSSDVFDI-------------------------FPGTYQTLEMFPR---------TPGIWLLTTYTVLQN
32pn5A 0.10 0.18 0.90 1.21Download ------------LLVVGPKFIQEYTLVISNFNSQLSKVDL--LLKLELSVLNVTKMVDVRRNMNRMMPEDLTAGNY-----------KITIDGQRGFSFKEAELVYLSK---------SISGLIQVDKKPGDTVNFRVIVDTELKPPARVKSVYVTIRDPQRNVIRKWSTAKL--------YAGVFESDLQIAPTPNISVEVEGVSKTFEVK-------EYVLSTFDVQ--VMPSVIPLEEHQAVNLTIEANYHFGKPVQGVAKVELYDDDKLKLKKELTVYGKGQ---VELRFDNFAM-------ADQQDVPVKV-----SFVEQYTNRTVVKQSQITVYRYAYR-VELIKESPQFRPGPFKCALQF-THHDGTPAKGISGKVEVSDVRFETTTTSDNDGL-IKLELQP---------SEGTEQLSIH-FNAVDGF---FFYEDVNKVETVTDA-Y-IKLELKS-PIKR-NKL-MRFMVTCTERMTFF-VYYVMSKGNIIDAGFMRPNKQPKYLLQLNATEKMIPRAKI----LIATVA-TVVYDFADLAFQELSIDEQEIKPGRIELSMSGRP------GAYVGLAAYDKALLLFNKNHDLFWEDIGQVFDGFHENEFDIFHSLG----LFARTLDDILFDSQESWLWKNVSSRKLIEVVP-TTSWYLTGFSIDPVYGLGII---KKPIQFTTVQPFYIVENLPYSIVVLQFTLFNNLGAEYIADVTLYNVANQTEFVGRDLSYTKSVSVP-PKVGVPISFL-IKARKLGEMAVRV---ASIMLGHETDA-LEKVIRVMPESLVQPRMDTRFFCFDDTKIEFRLNPNLLTTVIKNLDLGVPTGCGQNMVKFVPNILVLDYL-GSKETNLLRQGYQNQSFGLWETTNGSVFLTAFVGTSMQTAVKYISDILDWLASKQHFSGRFDKAGAEYHKEMQGGLRNGVALTSYVLMALLENDIAKAKHAEVIQKGMTYSINNAYDLSIA--TYAMMLNGHTMKALNKLIDMSFIDA--ERFWNTTNPIETTAYALLSFVMAEKMNWLVNQRYVTGSFPSTQDTFVGLKALTKMAEKISPSRNDYTVQLKYSAKQIDFVDIPEDTKKLEINVGGIGFGLLEVVYQLNLVNFENRFQLDLEKQNTYELRLKVCASYIPQLTDRRSVTLPSGYVVDRNPEQTKVNPIQKTEIRSVVLYYNMGSERNCFTLTAYRFKVA--LKRPAYVVVYDNAIKVYE
43fcsA 0.08 0.15 0.71 2.83Download LNLD-------------PVQLTFYAGPNGSQFGFSLDFHKDSHGRVAGPSQEETGGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSW---------------SDVIVACAPWQ-----------------------------------------------HWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVENDFSWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPVADIFSSY-------RPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNTTEYVVGAPTWSWTLGAVEILDSYYQ--------------------------------------------------------------RLHRLRGEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQP------------------------------------RGPHALGAPSLLLTGTQLYG------RFGSAIAPLGDLDRDGYNDIAVAAPYGG---PSGRGQVLVFLGQSEGLRSRPSQVLD----------------SPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQP------VVKASVQLLVQDSL------NPAVKSCVLPQTKTPVSCFNIQMCVGATGHNIPQKLSLNA--------ELQLDRQKPRQGRRVLLLGSQQAGTTLNLDLGGKHSPICHTTMAFLRDE-------------ADFRDKLSPIVLSLNVSLPPTEAGMAPAVVLHGDTHVQEQTRIVLD------------------------------------CGEDDVCVPQLQLTASVTGSPLLVGADNVLELQMDAANEGEGAYEAELAVHLPQG----------------------------------AHYMRALSNVFERLICNQKKENETRVV-------LCELGNPMKK-------NAQIGIAMLVSVGNLE---EAGESVSFQL------------------------------QIRSKNSQNPNSKIVLLDVPVRAEAQVELRGNSFPASLVVAASWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQLYILDIQPQGFPQPPVNPLKVDDPVLVSCDSAMARGQRAMVTVLAFLWLPSLYQRPLDQFVLQSLPYAVPPL-SLPRGEAQVWTQLLRAC
51kcwA 0.15 0.15 0.78 1.19Download --KE--------YYIGIIETTWDY-ASDH---GEKK---LISVDTEHSN-------IYLQNGPDRIGRLYKKA----LYLQYTDETFRTTIEKPVWLGFPIIKAET------G-----DKVYVHLKNLASRPY----------TFGITYYKEHEGAIYPDNTTDFQRADDKVY-EQYTYMLLATEEQSPGEGDGNCVTRIYHS------HIDAPKDIASGLIGPLIICKKDSLDK-EKEKHIDREFVVMF-SVVDENFSWYLED--------------------NIKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGL-------SMCAEDRVKWYLFGMGN----------EVDVHAAFFH-GQALT----NKNYRI-------DTINLF---PATLFDAYMVAQ---------NPGEWMLSCQNLLKAGL---QAFFQVQECRGKHVRHYYIAAEEIIWNYAPSGIDIFTKEN-LTAPGSDSAVFFEQGTTRILVYREYTDASFTNGPEEEHLGILGPVIWAEV--GDTIRVTFHNKGAYLSIEPIGVRFNKNN--EG---TYYSPVPPSASHVAP--TETFT--YEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIFT--GLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLL-FTTAPDQVDKEDEDFQESNKMHSMNG-----FMYGNQPGLTMC----KGDSVVWYLFSADVHGIYFSGNTYLWRERRDTANLF------------PQTSLTLHMWPDTEVECLTTDHYTGGMKQKYTVNQCRRQ-FYLGERTYYI-AAVEVEWDYSPQREWEKELHHLQEQNVSNAFL---------------DKGEFYIGSKYKKVVYRQYTDSTFRVPVERKAEEEHLGILGPQVGDKVKIIF---KNMATR-PYSIHAHGVQTESSTVTPTL---------ETLTYVWKIPERSGAG---TEDSACIPWAYYSTV---------DQVKDLYSGL-IGPLIVC--------RPRRKLEFAL---LFLVFDENESWYLDDNIKTYSDHPEKVN--------KDDEEFIESNKMHAINGRM-------------------FGNLQGLTMHVG-DEVNWYLMGMGNEIDL---HTVHFHGHSFQYKH--RGVYSSDVFD---IFPG----------TYQTLEFPRTPGIWLLHCVTDAG-----METTYTVLQN------
61m1xA 0.08 0.15 0.74 2.74Download FNL--------------DVDSPAEYSGPEGSYFGFAVDFFVPS----ASSRMFLLVGAPKANTTQP-----GIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRS------------------------------------------------KQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCR-------SQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSK---------YDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGLQEVGQVSVSLQRASGDFQTTKLN------GFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSM--------------------PPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILY----RARPVITVNAGLEVYPSILNQDN------KTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQV------ELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDE--------SEFRDKLTPITIFMEYRL----DYRTAADTTGLQP---------------ILNQFTPANISRQAHILGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEA--------------------------ELIVSIPLQADFIGVVRNN-------------EALARLSCAFKTE----------------NQTRQVVCDNPMKAGTQLLAGLRFSVHQ----QSEMDTSVKFDLQIQSSNL--------------------------FDKVSPVVSHKVDLAVLAAVEIRGVSSPD-----HVFLPIPNWEHKENPETEEDVGPVVQHIYELRN----NGPSSFSKAMLHLQW-----------PYKYNNNTLLYILHYDIDGPMNCTSDMEIN---------------------PLRIKISSLDIHTLG---------CGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSS---------------------------ASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQ
71wxrA 0.17 0.17 0.77 1.17Download ------------------GTVNN--LGYQAENATNIAIYN--FVGTLDKAAMP----FSAVDSEIGV---ATLINPQYIASVKYTNVSFG---DGENRYNIVDRN--NAPSLDFHAPRLDKLVTEVAPTAVTAQGAVAYLDKERYPVLGSGTQYIKDSNGQLTKMGGAYSWL------TGGTVGSLSSYQN------------G-EMISTSS------GLVFDY----LNGAMP--IYGEGDSGSPLFAFDT--------LVGVLTAGNGAGGRGNNWAVIPLDFIGQKFNEDNDA----PVTFRTSEGGALEWSFNSS-------TGAGALTQG-TTTYAMH-GQQ---GNDLNAG--KNLIFQG-----------QNGQINLKDSVSQGAGSLTFRTTSNGSTWT------AGIVVD--NGVSVNWQVNGVKGDLHKI--TLTVQGTGINEGGLKVGDGKVV-QQADNKGQVQ------AFSSVNIASGVLTDERQPDTVSWGYRGGTLDVNGNSLTFHQL-----KAADYG-AVLAN----DKRATITLDYARADKVALNGWSESGKGTAGNLYKYNNPY----TTD--YFILKQSTYGYFPTDQSSNATWEFVGQKLVADRFNTAGYLFGQLKG-NLNVDNRLPEGVTG-AADISGTFTQENGRLTLQGHPVIHAYNT-----------SVADKLAAGDHSVLTQPTSFWENRSFTFDRLSLK---TDFGLG-------RNATLNTTIQADN-------------SSVTL--GDSRVFIDKNDGQGTAFTLEEGTSVATKDADKSVFNGTVNLDN-QSVLNIN--DIFN-------GGIQA-----NNSTVNISSDSAVLG--NS-TLTSTALNLN-----KGANALASQSFVSDGPVNI-----SDATLSLNSRPDEVSHTLLPVYDYA-----SWNLKGDD-ARLNVGPYSMLSGNINVQDK--GTVTLGGEGE----------LSPDLTLQNQMLYSLFNGIWSGSLNA---PDATVSMTDTQWSMNGNSTAGNMKLNR----TIVGFNGFT--------TLTTDN-----DAVQSAFVMRTK-------------------------ADKLVIN-TGHDNSIWVNF-LKKPSN---DTLDIPLVSAPEAT----ADNLFRASTRVVGFSDV--TPILSVR----EDGKKEWVLDGYQVA-AATFMHISYNNFITEVN------
82cn2A 0.08 0.11 0.53 2.55Download V--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSVPYKWDNVVIGGGGGFPGIVFNETEKDLIYARADIGGAYRWDPSTETWIP----------------------------------------------------------------------------------------------------------------------------LLDHFQDEYSYYGVESIATDPVDPNRVYIVAGYTNDWLPNGAILRSTDRGETW------EKTILPFKGGNPGRSGERLAID--------------------PNDNRILYLGTR----CGNGLWRSTDYGVTWSKVESFPNPGTIIGVVWVVFDKSSST------PGNPTKTIYVGVADKNESIYRSTDGGVTWKAVPGQPKGLLPHHGVLASNGLYITYGDGKGQVWKFNTRTGEWID---------ITPIPYSSSDNRFCFAGLAVDRQNPDIIVTSNAWWPDEYIFR---STDGGATWKNIWEWGYPERILHYEIDISAAPWLDWGTEKQLPEINPKLGWIGDIEIDPFNSDRYVTGDWDRGGKVKIEVKATGIEECAVL----------DLVSPPEGAPLVSAVGDLVGFVHDDLK-----VGPKKHVPS-----------------------YSSGTGIDYAELVPNFALVAKAVKKISFSYDGGRNWFQPP--------------NEAPNSVGGGSVAVAADAKIWTPENASPAVTTDNGNSWKVCTNLGGAVVASDRVNGKKFYAFYNGKFYISTDGGLTFTDTKAPQLPKSVN--------KIKAVPGKEGHVWLAAREGG---------LWRSTDGGYTFEKLSNVDTAHVVGFGKAAPGQDYAIYITGKI--------DNVLGFFRSDINDDEHGYGAVDTAITGDPYGEPAS
91k32A 0.13 0.17 0.79 1.13Download MPN----LLLN----DIHGDRIIFV-------CCD-DLWEHDLTRKIVSNLGVINNARF-----FPDGR----------------KIAIRVMRGSSLNTADLYF----------YNGENGEIKRITYFSGKSTGRRMFTDV---AGFDPDGNLIISTDAMQPFSSM--------TCLYRVENDGI-----------NFVPLNLGPATHILFADGRRVIGR--------NTFELPHWKGYRGGTR---GKI--WIEVNSGAFKKIVDMSTHVSSPVIV-RIYFITDIDGFGQIYSTDLDGKDLRKHTSFTDYYPRHLNTDGRRILFSKGSIYIFNPDTEKIEKIEIGDLESPEDRIISIPSKF---------AEDFSPLDGD--LIAFVSRGQAFIQDVSGTYVLKVPEPLIRYVRRG---GDTKVAFI--HGTREG--DFLGIYDYTGKFEENLGN---VFAMG---VDRNGK----FAV------------VANDRFEIMTVDLETGKPTVI--ERSREAMITDFTIS-DNSRFIAYGFPLKHGVMQAIHVYDME--RKIFAATTENSHDYAPAF-----DA------DSKN-LYYLSYRSLDPSPDRVVLNFSFE---------VVSKPFVIPLIPGS---PNPTKLVPRSMTSE-AGEYDLND----MYKRSSP---INVD---PGDYRMIIPLSSILIYSVPVHGE-----FAAYYQG------APEKGVLLKYDVKTRKVTEVKNNLTDLRLSATVMV--RKDDGKIYT-FPLEKP-----EDERTVETDKRPLVSSIHEEFLQMYDEAWKL---ARDNYWNEAVAKEISERIYEKYRNLVPLCKTRYDL-SNVIVEM-----QGEYRTSHSYEMGGTFTDACDFKLD-HYVVAKAYAGDYSNEGEK---SPIFEYGIDPT---YLIEDIDGETVGAGSNIYRVLSEKAG-TSARIRLSGKGDKRDLMIDILDDDRFIRYRSWVE-----ANRRYVHERSKGTIGYIHI------PDMGMMGLNEFYRLFINES---SYQGLIVDVRFNGGGFVSQLIIE------KLMNKRIGYDN---------------PRRGTLSPYPTNSVR----GKIIA--TNEYAG-SDGDIFSF-------SFKKLGLGKLIGTRTWGGVVGITPKRRLIDGTVLTQPEFAFW-----FRDAGFGVVD-VEIEYAPHDYLSGKDPQIDYA-IDALIE
102vsaA 0.08 0.14 0.65 2.53Download PNSPKDNTWIQAASLTWL--------------------------------------------------------------------------------------------------------------MDMSSLLYQLISTRIPSFASPNGLHM--------------------------------REQTIDSNTGQIQIDNEHRLLRWDRRPPNDIFLNG-----------------------------------------------------------FIPRVTNQNLSPVEDTHLLNYLRTNSPSIFVSTTRARYNNLGLEITPWTPHSANNNIIYRYEIFAPGGIDINASFSRNPN-----------------------------EDEITFPGGIRPEFIRSTYEYHNGEIVRIWINPNFINPSTLNDVSGPSNISKVFWHENHSEGNNMDS--------------------------------------NQDFDMFAPNGEIPNNNLLNNNSLNVIQNSEYQIKNKKDRNIVVTL---DSDYGGSPVESYKNFGFENQKWNIKYDSKKNAYKIYNRETPTLLLSWN---SNSSNGEQVIRGYTESGSNNQYWTIEK----NVNGFYKFRNLSDPSKILDLKDGNTLNKTPLVVSS--ENSSSSQEWLIEKTNYQTVKDGTYQV-----SSKLNENKVIEQISTNKVHIFSNSDKENQVWNLIYNPILKAYKIKSLKYPNY----SLAWDSNNTRTIVAATGDYNDQYWLIERNEDNTYIIRNY---ENRKIVLDLSNGSTTDGNGLLGFEFHGGINQRWIIKPFS-------------FNSIQDGIYQFMTVINQDLIADLTT----NNYTIATKTVTYNDKKRAYKIRNLQHAHLSLAWDSNHSDKIFGATGDY------------------------------------DDQYWIPILQTDGSFIFRNYKNPNKIFGTNGQKAQDVTGQ---------------NNQKWYLRHLNSSNNFTGYFNISSKKNFN-----------------KIITMNSNKTQAVIFDNIGINNQSWKLKYN-------------------DNKNAYQIHILDNFLYFQGGHNIVATMRNVTNDDLRSYWYVEYN----------FNKDGFIIRNAFDTSY---------VLDVFQGNFANNTPIITY---QNYLNDNQ--------LWNFIPSLG
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: MUSTER   2: PROSPECT2   3: MUSTER   4: PROSPECT2   5: MUSTER   6: PROSPECT2   7: MUSTER   8: PROSPECT2   9: MUSTER   10: PROSPECT2   

  10 proteins in PDB which are structurally closest to the first I-TASSER model (identified by TM-align)

RankTM-scoreRMSDaIDENaCov.PDB
Hit
10.7879 1.38 0.06 0.801kcwA
Model1
 
20.4536 3.76 0.05 0.492r7eA
Model1
 
30.2933 9.71 0.05 0.461kekA
Model1
 
40.2925 9.23 0.04 0.441llwA
Model1
 
50.2914 9.43 0.05 0.453ffzA
Model1
 
60.2898 9.38 0.03 0.441ea0A
Model1
 
70.2826 4.70 0.06 0.321aozA
Model1
 
80.2798 8.50 0.04 0.402vc9A
Model1
 
90.2778 9.57 0.04 0.433ecqA
Model1
 
100.2761 4.76 0.07 0.311gw0A
Model1
 
Structural alignment using TM-align
 
KEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQEC-IRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPVPPSASHVAPTETFTYEWTVPKEVGPTNA------------------------------------------------DPVCLAKMYYSAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLL--L------EDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVE---------------CLTTDHYTGGMKQKYTVNQCRRQSEDSTFYLGERTYYIAAVE-V----EWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKKVV---------------------YRQYTDSTFRVPVERKAEEEHLGILGPQLHAD------------------VGDKVKIIFKNMATRPYSIHAHGVQTESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLY-------------------SGLIGPLIVCRRPRRKLEFALLFLVFDENESWYLDDNIKTYSDH---------------------------PEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMH-----------------------------------------------------VGDEVNWYLMGMGNEIDLHT---VHFHGHSFQYKHRGVYSSDVFDI-------------------------FPGTYQTLEMFPR---------TPGIWLLHCHVTDHIHAGMETTYTVLQN 
MNKTLGLILTSVFLLSTLGIITGFVIPTQAANSNDAAIYTIPSVTSVSNTSNIVINLFFNATSNSTVGAQASAFNYGLAINYTLDAITFTVVLPSGTSYPLIKLNAKNFANYGYYDLAHNSIVLLLNTTASSTAKELAYSYEQSIGVTPSASYKIYNYTNKTVNVNQYMNELPLSMLIYMATNGKYNNLASLPVGTKLEFTYAGVTYIIAVSPTVKLVGELLNPLYTANSKMLPGTNYAVGRSNITVAVYDNLITTTTSPFNFTLTYSSLAPALIYWFVIANTTYTNNGASTPTASF--------------------QAP-PFKQYFPSNSTILYSAAPTKSSILMFNGQ-MNVTAHENVTLTLQTGTNIYTSPNFNVT--PPGNYTFSGKLGVGFNGFIYQNGSATLTATIFNGTINFFFSSTGQKAAFTFFLVPIVPINLGDNNGATVIYNGVSLNTGFPQVVVMFNITGNFTKSGSNYLLYGSVYEAELKPLGSTQLQKLAGATDSTQFVGNLISSASSPLVSYFNYGESTTTITGTSLSFTVLMPLKFIVERLGYIYLVTFHIWGPSATVTVTGVDYHGTQIALGSFRAYVALPSFYTLPKTPLVGLTCDNMYTLAQVSDAGSVLETSTANSNANNATVIGPYDLMSNAGLHVAIYNGSKLVKSGNLGLLPNATTAPITTTITLNGQTVALTYSSAPTAIYPVDFKFEPGFSYSVTTNVIYNTSIPTYVVTVYMPLKYILQTKIVMWYVSPDYAAYFYYSSTGQYQTSNVTLTFANVTPELVMPQVFPVGKLYMPFGINDPYYVFYSSISIGPQSGVIEAVENGFNVGNITSITVELNGMNESIVLSPLNVSKLLISSNLGEVSQCSPLFTTTLFNISALASLLGLPNAAALNGSYLYVTYHDIISGAYVTNRT-LLVVGQFYVMPPTTPGSVEWILTAKYINATTGIPVEISYAVVQQPSAKVVDINAANASITQIQVTGVKIVSKYATVTVMYNPSNASTIVYMNGMFVASYGGNLISSLSETSTFGVYYGAVVNLYVATGTLSSPNGTMYVVLGSHKVAVGTANLYTYAGYHFGPYTALPLVSNVTFTVQDPVTHATLTGQTTLGAFNNTPIRLAPLGVSIPQTAQYKVFYYYSTPLVLSPTSQYIVLSVTSVISYPYPFYIETVSFLGYNVTTGTPVPGTPAFQTVYSPSLGPGVVLQVPVQSYQFISLSTPSEPHTVVMFAVPFAGGPAISLYPTFLVY-------------ANVTAISS 
 
ATRRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSF-----------------PF--NTSVVYKKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGALLVCREGSLAKEK-TQTLHKFILLFAVFDEGKSWHSETKNAASA--R--A------W---PKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQFDDDNSPSFIQIRSVAKKH----PKTWVHYIAAEEEDWD-YAPLV-----LAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETF-KTREAIQ--HESGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGITDVRPLYSRRLPK-------GVKHLKDFPILPGEIFKYKWTVTVEDGPTKS------------------------------------------------DPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQI-M-SDKRNVILFSVFDEN-R-SWYLTE-----NIQRFLPNPAGVQLE-DPEFQASNIMHSINGYVFDS-LQLSVCLHEVAYWYILSIGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCH---------------NSDFRNRGMTALLKVSSCDKNTGDYYEDSYED------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ 
MNKTLGLILTSVFLLSTLGII-----------------TGFVIPTQAANSNDAAIYTIPSVTSVSNTSNIVINLFFNATSNSTVGAQASAFNYGLAINYTLDAITFTVVLPSGTSYPLIKLNAKNFANYGYYDLAHNSIVLLLNTTASSTAKELAYSYEQSIGVTPSASYKIYNYTNKTVNVNQYMNELPLSMLIYMATNGKYNNLASLPVGTKLEFTYAGVTYIIAVSPTVKLVGELLNPLYTANSKMLPGTNYAVGRSNITVAVYDNLITTTTSPFNFTLTYSSLAPALIYWFVIANTTYTNNGASTPTASF--------------------QAPPFKQYF-PSNSTILYSAA------------------------PTKSSILMFN-GQMNVTAHENVTLTLQTGTNIYTSPNFNVTPP-GNYTFSGKLGVGFNGFIYQNGSATLTATIFNGTINFFFSSTGQKAAFTFFLVPIVPINLGDNNGATVIYNGVSLNTG-------FPQVVVMFNITGN-F-TKSGSNYLLYGSVYEAELKPLGSTQLQKLAGATDSTQFVGNLISSASSPLVSYFNYGESTTTITGTSLSFTVLMPLKFIVERLGYIYLVTFHIWGPSATVTVT-GVDYHGT-QIALGSFRAYVALPSFYTLPKTPLVGLTCDNMYTLAQVSDAGSVLETSTANSNANNATVIGPYDLMSNAGLHVAIYNGSKLVKSGNLGLLPNATTAPIT-T-TITLNGQTVALTYSSAPTAIYPVDFKFEPGFSYSVTTNVIYNTSIPTYVVTVYMPLKYILQTKIVMWYVSPDY----------AAYFYYSSTGQYQTSNVTLTFANVTPELVMPQVFPVGKLYMPFGINDPYYVFYSSISIGPQSGVIEAVENGFNVGNITSITVELNGMNESIVLSPLNVSKLLISSNLGEVSQCSPLFTTTLFNISALASLLGLPNAAALNGSYLYVTYHDIISGAYVTNRTLLVVGQFYVMPPTTPGSVEWILTAKYINATTGIPVEISYAVVQQPSAKVVDINAANASITQIQVTGVKIVSKYATVTVMYNPSNASTIVYMNGMFVASYGGNLISSLSETSTFGVYYGAVVNLYVATGTLSSPNGTMYVVLGSHKVAVGTANLYTYAGYHFGPYTALPLVSNVTFTVQDPVTHATLTGQTTLGAFNNTPIRLAPLGVSIPQTAQYKVFYYYSTPLVLSPTSQYIVLSVTSVISYPYPFYIETVSFLGYNVTTGTPVPGTPAFQTVYSPSLGPGVVLQVPVQSYQFISLSTPSEPHTVVMFAVPFAGGPAISLYPTFLVYANVTAISS 
 
GKKMMT-TDGNT-----------------------------------------ATAHVAYAMSEVAAIYPIT----------PSSTMGEEADDWAAQGRKNIFGQ--------------TLTIREMQSEAGAAGAVHGALAAGALTTTFTASQGLLLMIPNMYKISGELLPGVFHVTARAIAAHALS-----------------IFGDHQDIYAARQTGFAMLASSSVQEAHDMALVAHLAAIESNVPFMHFFDGFRTSHEI---QKIEVLDYADMASLVNQKALAEFRAKSMNPEHPHVRGTAQNPDIYFQGREAANPYYLKVPGIVAEYMQKVASLTGRSYKLFDYVGAPDAERVIVSMG--------SSCETIEEVINHLAAKGEKIGLIKVRLYRPFVSEAFFAALPASAKVITV-LDRTKEPGAPGDPLYLDVCSA-FVERGEAMPKI--------LAGRYGLGSKEFSPAMVKSVYDNMSGAKKNHFTVGIEDDVTGTSLPVDNAFADTTPKGTIQCQFWGLGADGTVGANKQAIKIIGDNTDLFAQGYFSYDSKKSG--GITISHLRFGEKPIQSTYLVNRADYVACH-NPAYVGI---YD--I----LEG-IK-DGGTFVL--------------------------------------------------------------------------------NSPWSSLEDMDKHL-------PSGI--KRTIANKK----------------------LKFYNIDAVKIATDVGLGGRINMIMQTAFFKLAGVLPFEKAVDLLKKSIHKAYGKK-G--E----KIVKMNTDAV-DQAVTSLQEFKYPDS--------------WK-DAP--------AETKA----------------------EPMTNEFFKNVVKPILTQQGDK------------------------LPVS-AFEADG----------------------------------RFPLGTSQF---------------EKR----GVAINVPQWVPEN-CIQCN----------QCAFVCPHSAILPVLAKEEE--------LVGAPANFTAL-EAK-------GKELKGYKFRIQINTLDCMGCG--------------------------------------------------------------------------------------------------------NCADIC----------P-PKEKALVMQPLDTQRDAQVPNLEY---------------------AA-RIPVKSEVLPRDSLKGSQFQEPLMEFSGA---------CSGCGETPYVRVITQLFGERMFIANATGCSSIWGASAPSMPYKTNRLGQGP-AWGNSLFEDAA----------------------EYGFGM-N-MSMFARRTHLADLAAKALESDASGDVKEALQGW-----------LAGKNDPIK----SKE-YGDKLKKLLAGQKDGLLGQIAAMSDLYTK-KSVWIFGGDGWAYDIGYGGLDHVLASGEDVNVFVMDTEVYSNTGGQSSKATPTGAVAKFAAAGKRTGKKDLARMVMTYGYVY--------VATVSMGYSKQ-------QFLKVLKEAESFPGPSLVI----------AYATCI-------------------NQGLRKGMGKSQDVMNTAVKS------------GYWPLFRYDPRLAAQGKNPFQLDSKAPDGSVEEFLM------------------------AQNRFAVLDRSFPEDAKRLRAQVAHE-------LD-VRFKELEHMAATNIFESFAPAGGKADGSVDFGEGAEFCTRDDTPMMARPDSGEACDQNRAGTSEQQGDLSKRTKK- 
MNKTL-GLILT-SVFLLSTLGIITGFVIPTQAANSNDAAIYTIPSVTSVSNTSNIVINLFFNA---------TSNSTVGAQASAFNYGLAI-NY-TLDAITFT--VVLPSGTSYPLIKLNAKNFANYGYYDLAHNSIVLL-----LNT---------T---A--SS--TAKELAYS-----------YEQSIGVTPSASYKIYNYTNKTVNVNQYM---------------------------------NELPLSM-LIYMATNGKYNNLA-------------------------------------------------------------------------------------------SLPVGTKLEF-TY--------------------------------------------AGVTYIIAVS-PTVKLVGELL-NPL---------YTANSKMLPGTNYAVGRSNITVAVY-----------------------------------DNLI-TTTTSP-----------FNF---------------TLTYSSLAP--ALIYWFV--------------IA-NTTYTNNGASTPTASFQAPPFKQYFPSNSTILYSAAPTKSSILMFNGQMNVTAHENVTLTLQTGTNIYTSPNFNVTPPGNYTFSGKLGVGFNGFIYQNGSATLTATIFNGTINFFFSSTGQKAAFTFFLVPIVPINLGDNNGATVIYNGVSLNTGFPQVVVMFNITGNFTKSGSNYLLYGSVYEAELKPL------GSTQLQ--------------------KL-AGATDSTQFVGNLISSASSPLVSYFNYGESTTTIT---------GTSLSFTVLMPLKFI-VERLGYIYLVTFHIWGPSATVTVTGVDYHGTQIALGSFRAYVALPSFYTLPKT--------PLVGLTCDNMYTLAQVSDAGSVLETSTANSNA---NNATVIGPYDLMSNAGLHVAIYNGSKLVKSGNLGLLPNATTAPITTTITLNGQTVALTYSSAPTAIYPVDFKFEPGF-SY----SVTTNVIYNTSIPTYVVTVYMP--------LKYILQTKIVMWYVSPDYAAYFYYSSTGQYQ---------------------TSNVTLTFANVTPELVMPQVFPVGKLYMPFGINDPYYVFYSSISIGPQSGVIEAVENGFNVGNITSITVELNGMNESIVLSPLNVSKLLISSNLGEVSQCSPLFTTTLFNISALASLLGLPNAAALNGS-----------------YLYVTYHDIISGAYVTNRTLLV-VGQFYVMPPTTPGSVEWIL-----------TAKYINATTGIPVEISYA-VVQQPSAKVVDI-------------------NAAN-ASIT-QIQVTGVKIVSKYATVTVMYNPSNASTIVYMNGMFVASYGGNLISSLSETSTFGVY--------------------YGAVVNLYVATGTLSS----PNGTMY-VVL-------------GSHKVAVGTANLY-TYAGYHFGPY-TA---LP--L-----------V-SNVTF--------TVQDPVTHA------TLTGQTTLGAFNNTPIRL---APLGVSIPQTAQ-------YKVFYYYST-----------------PLVLSPTSQYIVLSVTSVISYPYPFYIETVSFLGYNVTTGTPVP------------GTPAFQTVYSPSLGP---------------------------------GVVLQVPVQSYQFISLSTPSEPHTVVMFAVPFAGGPAISLYPT-------FLVYANVT-AIS-------------------------------------------------------------------------S 
 
CGVGFIANLRGKPDHTLVEQALKALGCMEHRGGCSADNDSGDGAGVMTAIPRELLAQWFNTRNLPMPDGDRLGVGMVFLPQEPSAREVARAYVEEVVRLEKLTVLGWREVPVNSDVLGIQAKNNQPHIEQ---------------------------------------------ILVTCPEGCAGDELDRRL-YIARSIIGKKLAEDFYVCSFSCR---TIVYK-----GMV-----RSIILGEFYLDLKNPGYTSNFAVYHRRFSTN-------TMPKW-------PLAQPMRLLGHNGEINTLLG--NINWMAAREKELEVSGWTKAEL---------------EALTPIVNQANSDSYNLDSALELLVRTGRSPLEAAMILVPEA---YKNQ-PALKDYPEISDFHDYYSGLQEPWDGPALLVFSDGKIVGA-----------------------GLDRNGLRPARYCITKDDYIVLGSEAGVVDLPEVDIVEKGRLAPGQMIAVDLAEQKILKNYQIKQQAAQKYPYGEWIKIQDAQTVL--------------------------------------------------------QQQAAFGYTAEDVE------MV-----VVPMAS-QGKEPTFCMGDDTPLA--------------------VLSHKPRLLYDYFKQRFAQVTNPPIDPLRENLVMSLAMFLGKRGNLLEPKAEKLRSPLVN---------------EVE-LQAIKTGQLQVAEVSTLYDLDGVNSLEDALTNLVKTAIATVQAGAEILVLTDRPNGAILTENQSFIPP----------------------------------------------------------------LLAVGAVHHHLIRAGLRLKASLIVDTAQCWST------------------------HHFACLVGYGASAICPYLALESVRQWWLDEKTQKLMENGRLDRIDLPTALKNYRQSVEAGLFKILSKMGISLLA--------------------------SYHGAQIFEAI-----GLGAEL----VEY-AFAGTTSRVGGLTIADVAGEVMVFHGMAFPEMAKKLEN-----FGFVNYRPG----GEYHMNSPEMSKSLHKAVAAYYDHYELYRQ-------------------YLKDRPVTALRDLLDFNADQPAISLEEVESVESIVKRFCTGGMSLGALSREAHETLAIAMNRLGAKSNSGEGGEDVVRYLTLDDVDSEGNSPTLPHLHGLQNGDTANSAIKQIASGRFGVTPEYLMSGKQLEIKMAQGAKPGEGGQLPGKKVSEYIAMLRRSKPGVTLISPP---------------------------PHHDIYSIED----LAQLIYDL---HQINP--EAQVSVKLVAEIGIGTIAAG--------------VAKANADIIQISGHDGGTGASPLSSIKHAGSPWELGVTEVHRVLMENQLRDRVLLRADGGL----------KTGWDVVMAALMGAEEYGF---GSIAMIAEGCIMA-------RV-CHTNNCPVGVATQQERLRQRFKGVPGQVVNFFYFIAEEVRSLLAHLGYRSLDDIIGRTDLLKVRSDVQLSKTQNLTLDCLL-------------------------------------------NLPDTKQNRQWLNHEPVHSNGPVLDDDILADPDIQEAINHQTTATKTYRLVNTDRTVGTRLSGAI--------------AKKY--GNNGFEGNIT----LNFQGAAGQSFGAFNLDGMTLHLQGEANDYVGKGMNGGEIVIVPHPQASFAPEDNVIIGNTCLYGATGGNLYANGRAGERFAVRNSVGKAVIEGAGDHCCEYMTGGVIVVLGPVGRNVGAGMTGGLAYFLDEVGDLPEKINPEIITLQRITASKGEEQLKSLITAHVEHTGSPKGKAILANWSDYLGKFWQAVPPSEKDSPEANN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ 
---------------------------------------------------------------------------------------MNK-TLG-LI---------------------------------LTSVFLLSTLGIITGFVIPTQAANSNDAAIYTIPSVTSVSNTSNIVINLFF-NATSNSTVGA-QASAFNYGLAINYTLDAITFTVVLPSGTSYPLIKLNAKNFANYGYYDLAHNSIVLLLNT--TASSTAKE-------LAYSYEQSIGVTPSASYKIYNYTNKTVNVNQYMNE----LPLSM-LI----------------YMATNGKYNNLASLPVGTKLEFTY------AG--VT--YI---IAVSPTVKL-----VGEL---LNPLYTANSKMLPGTNYAVGRSNI----------------TVAVYDNLITTTTSPFNFTLTYSSLAPA---------------------------------------------------------------------------------LIYWFVIANTTYTNNGASTPTASFQAPPFKQYFPSNSTILYSAAPTKSSILMFNGQMNVTAHENVTLTLQTGTNIYTSPNFNVTPPGNYTFSGKLG----------VGFNGFIYQNGSATLTATIFNGTINFFFSSTG------------------------------------------------QKAAFTFFLVPIVPIN--LGD--N-------NGATV--------IYN-GVSLNTGFPQVVVMFNITGNFT--KSGSNY-LLYG----SVYEAELKPLGSTQLQKLAGATDSTQFVGNLISSASSPLVSYFNYGESTTTITGTSLSFTVLMPLKFIVERL-----------GYIYLVTFHIWG-PSATVTVTGVDYHGTQIALGSFRAYVALPSF---YTLPKTPLVGLTCDNMYTL--AQ--------VSDAGSVLETSTANSNANNATVI----------GPYDLMSNAGLHVAIYNGSKLVKSGNLGLLPNATTAPITTTITLNGQ-TVALTY-SSAPTAIYPVDFK--------------------------FEPGFSYSVT----TNVIYNTSIP------------------------TYVVTVYMPLKYILQTKIVMWYVSPD----Y--AAYF--YYSS--TGQ---YQ-TS---------------------------NV------------------------------------------TLT------------FANVTPELVMP--------------------------------------QVFPVGKLYMPFGINDPYYVFYSSISIGPQSGV----IEAVENGFNVGNITSITVELNGMNESIV--------------LSPLNVSKLLISSNLGEVSQCSPLF-------------------------T---TT--L----F-----------NISALASLLGLPNAAALNGSY-LYVTYHDIISGAYVTN-------RTLLVVGQ-FY--------VM-----------PPTT-PG--SV-EW--I--LT-AK-------YINATTGIP-------------------VEISYAVVQQPSAKVVDINAANASITQIQVTGVKIVSKYATVTVMYNPSNASTIVYMN--------------------------------------------------GMFVASYGGNLISSL---SETST-------FGVYY-G--AVVNLYVATGTL-S-S--------PNGTMYVV-----------------------------LGSH----------KVAVG-----------TANLYTYA-----------------------------------------------------------------------------------------------------GYHFGPYTALPLVSNVTFTVQDPVTHATLTGQTTLGAFNNTPIRLAPLGVSIPQTAQYKVFYYYSTPLVLSPTSQYIVLSVTSVISYPYPFYIETVSFLGYNVTTGTPVPGTPAFQTVYSPSLGPGVVLQVPVQSYQFISLSTPSEPHTVVMFAVPFAGGPAISLYPTFLVYANVTAISS 
 
PKINSFNYNDPVNDRTILYIKPGGCQEFYKSFNIMKNIW---------------------------------------IIPERNVIGTT--PQDFHPPTSLKNGDSSYYDPNYLQSDEE--------------KDRFLKIVTKIFNRINNNLSGGILLEELSKANPYLGNDNTPDNQFHIGDAS---------------AVE--IKF--SNGSQDILLPNVIIMGAEPDLFETNSSNISLRNN--YMPSNHGFGSIAIVTFSPEYSFRFNDNCMNEFI----QDPALTLMHELIHSLHGLYGAKGI-TTKYTITQKQNPLITNIRGTNIEEFLTFGGTDLNIITSAQSNDIYTNLLADYKKIASKLSKVQVSNPLLNPYKDVFEAKYGLDKDASGIYSVNINKFNDIFKKLYSFTEFDLATKFQVKCRQTYIGQYKYFKLSNLLNDSIYNISEG----YNINNLKVNFRGQNANLNPR--IITPITGRGLVKKIIRFCKNIVSVKGIRKSICIEINNGEL----------------------FFVASENSYNDDNINTPKEIDDTVTS---NDLDQVILNFNSESAPGLSDEKLNLTIQNDAYIPKYDSNG---------------TSDIEQHDVNELNVFFYLDAQKVPEGENNVNLTSSIDTALLEQPKIYTFFSSEFINNVNKPVQAALFVSWIQQVLVDFTTEAN--------------------------------------------------QKSTVDKI-------------------ADI----------------SIVVPYIGLA-------LNI-G------NEAQKGNFKDALELLGAGILLEFEPELLIPTILVFTIKSFLGSSDNKNKVIKAINNALKERD-------------------------------------------EKWKEVYSFIVSNWMTKINTQFNKRKEQMYQALQNQVNAIKTIIESKYNSYTLEEKNELTNKYDIKQIENELNQKVSIAMNNIDRFLTESSISYLMKIINEVKINKLREYDENVKTYLLNYIIQHGSILGESQQELNSMV-------------------------------------------------------------------TDTLNNSIPFKLSSYTDDKILISYFNK---FFKRIKSSSVLNMRYKNDKYVD-----TSG-------YDSNININGDVYKYPTNK------------NQFGIYNDKL----SEVNISQNDYIIYDN-KY-K--NF--SISFWVRIPNYDNKIVNVNNEYT--------------------------------------------IINCMRDNNSGWKVSLNH------------------NE-IIWTLQDNAGINQKL--AFNYGNANGISDYI-------NKWIFVTIT--------------NDRLGDSKLYINGNLIDQKSILNLGN--------------IHVSDNILFKIVNCSYTRYIGIRYFNIFDKELD-----ETEI---------------------------------------QTLY------SNEPNTNILKDFWG--------NY--------------LLYDKEYYLLNVLKPNNFIDRRKDSTLSINNIRSTILLANRL--YSGIKVKIQRVNNS---------------------STNDNLVRKNDQVYINFVASKTHLFPLYADTATTNKEKTIKISSSGNRFNQVVVMNSVGNNCTMN---FKN-NNGNNIGLLGFKADTVVASTWYYTHMR-DHTNSNGCF-WNFISEEHGWQEK------------------------------------------------------------------------------------------------------------------ 
--------------------MNKTL--GLILTS------VFLLSTLGIITGFVIPTQAANSNDAAIYTIPSVTSVSNTSNIVINLFF--NATSNSTV---G-AQASAF-----------NYGLAINYTLDAITFTVVLPS-GT-SY----------PLIKLNAKNFAN----------------YGYYDLAHNSIVLLLN--TTA--SSTA---KELAYSY---------------EQS----IGVTPSASYKIYNYTNKT-----------------VNVNQYMNELPL-SM-LI-YMATNGKYNNLASLPVG----------TKLE--F--TY--------------------------------------------------------------------------------AG--V--TYII------------AVSPTVKLVGEL----LNPLYTANSKMLPGTNYAVG-R--SNITVAV---YDNLITT-------------------------TTSPFNFTLTYSSLAPALIYWFVIANTTYTNNGAST------------PTAS---------------------------------------FQAPPFKQYFPSNSTI-LYSAAPTK-------------------------------------------------------------------------SSILMFNGQMNVTAHENVTLTLQTGTNIYTSPNFNVTPPGNYTFSGKLGVGFNGFIYQNGSATLTATIFNGTINFFFSSTGQKAAFTFFLVPIVPINLGDNNGATVIYNGVSLNTGFPQVVVMFNITGNFTKSGSN-YL--LY-G-SVYEAELKPLGST---------------------------QLQKLAGATDSTQFVGNLISSASSPLVSYFNYGESTTTITGTSLSFTVLMP-LK--F---IV--ER-LG-----------------------------------------------------YIYLVTF--HI-WG-PSATVTVTGVDYHGTQIALGS-------------------------FRAYVALPSFYTLPKTPLVGLTCDNMYTLAQVSDAGSVLETSTANSNANNATVIGPYDLMSNAGLHVAIYNGSKLVKSGNLGL-LPNATTAPI-TTTITLNGQTVALTY-SSAP-----TAIYPVDFKFEPGFSYSVTTN------------VIYNTSIPTYVVTVY-------MPLKYILQTKIVMWYVSPDYAAYFYYSSTGQYQTSNVTLTFA-----------NVTPELVMPQVFPVGKLYMPFGINDPYYVFYSSISIGPQSGVIEAV----------------ENGFNVGNITSITVELNGM-NE--------------SIVLSPLNVSKLLISSNLGEVSQCSPLFTTTLFNISALASLLGLPNAAALNGSYLYVTY-------------HDIISGAYVTNRTLLVVG-QFYVMP--P--TTPGSVEWILTAKYINATTGIPVEISYAVVQQPSAKVVDINAANASITQIQVTGVKIVSKYATVTVMYNPSNASTIVYMNGMF------VASYGGNLI-SSLSETSTFGVYYGAVVNLYVA----------------------------------TGTL-SSPNGT-----MYVVLGSHKVAVGTANLYTYAGYHFGPYTALPLV----------------------------------------SNVTFTVQDPVTHATLT-GQTTLGAFNNTP----IRLAPLGVSIPQTAQYKVFYYYST------------PLVLSPTSQYIVLSVTSVISYPYPFYIETVSFLGYNVTTGTPVPGTPAFQTVYSPSLGPGVVLQVPVQSYQFISLSTPSEPHTVVMFAVPFAGGPAISLYPTFLVYANVTAISS 
 
CGVGFIAAIDGKPRRSVVEKGIEALKAVWHRGAVDADGKTGDGAGIHVAVPQKFFKDHVKVIGHRAPDNKLAVGQVFLPRISLDAQEACRCIVETEILAFGYYIYGWRQVPINVDIIGEKANATRPEIEQI----------------------------------------------IVGNNKGVSDEQFELDLYIIRRRIEKAVKGEQINDFYICSLSAR-----SIIYK----GMF--L--AEQLTTFYPDLLDERFESDFAIYHQRYSTN------TFPTW-----PLAQPFRMLAHNGEINTVKGN---VNWMKAHETRMEHPAFGTH------------------MQDLKPVIGVGLSDSGSLDTVFEVMVRAGRTAPMVKMMLV--PQALT---TTPDNHK-ALIQYCNSVMEPWDGPAALAMTDGRWVVG-----------------------GMDRNGLRPMRYTITTDGLIIGGSETGMVKIDETQVIEKGRLGPGEMIAVDLQSGKLYRDRELKDHLATLKPWDKW-------------------------------VQNTTHLDELVKTASLKGEPSDMDKA----------------------ELRRRQQAFGLTMED-----MEL-----ILHPMVEDGKEAIGSMGDDSPIAVL---------------------SDKYRGLHHFFRQNFSQVTNPPIDSLRERRVMSLKTRLGNLGNILDEDETQTRLLQLESPVLT----------------TAEFRAMRDYMGDTAAEIDATFPVDGGPEALRDALRRIRQETEDAVR-GGATHVILTDEAMGPARAAIPAI-------------------------------------------------------------------LATGAVHTHLIRSNLRTFTSLNVRTAEGLDT-----------------------HYFAVLIGVGATTVNAYLAQEAIAER-HRRGLFGSMPLEKGMANYKKAIDDGLLKIMSKMGISVI-------------------------SSYRGGGNFEAIG----LSRAL----VAEHFPAMVSRISGIGLNGIQKKVLEQHATAYNEEVVALPV----GGFYRFRKSG------DRHGWEGGVIHTLQQAVTNDSYTTFKKYSEQVNK------------------RPPMQLR-DLLELRSTKAPVPVDEVESITAIRKRFITPGMSMGALSPEAHGTLNVAMNRIGAKSDSGEGGEDPARFRPDKNGDNWNSAIKQVASGRFGVTAEYLNQCRELEIKVAQGAKPGEGGQLPGFKVTEMIARLRHSTPGVMLI--------------------------SPPPHHDIYSIE----DLAQLIYDL-KQINPD--AKVTVKLVSRSGIGTIA------------AGVAKANADIILISGNSGGTGASPQTSIKFAGLPWEMGLSEVHQVLTLNRLRHRVRLRTDGGLK---------TGRDIVIAAMLGAEEFGIGTASLIAMGCIMVRQCHSNTCPVGVCVQDDKLRQKFV------------GTPEKVVNLFTFLAEEVREILAGLGFRSLNEVIGRTDLLHQVD-LDLN-P-R---------------------------------------LAQVDPGGR---NEVPDTLDARIVADARPLFEEGEKMQLAYNARNTQRAIGTRLSSMVTRKF-------------------GMFGLQ--PGHITIRLRGTAGQSLGAFAVQGIKLEVMGDANDYVGKGLSGGTIVVRPTTSSPLETNKNTIIGNTVLYGATAGKLFAAGQAGERFAVRNSGATVVVEGCGSNGCEYMTGGTAVILGRVGDNFAAGMTGGMAYVYDLDDSLPLYINDESVIFQRIEVGHYESQLKHLIEEHVTETQSRFAAEILNDWAREVTKFWQVVPKEMLNRLEVPVHL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ 
--------------------------------------------------------------------------------------M--N--KT-LGL---------------------------------ILTSVFLLSTLGIITGFVIPTQAANSNDAAIYTIPSVTSVSNTSNIVINLFFNATSNSTVGAQASAFNYGLA-I----NYTLDAITFTVVLPSGTSYPLIKLNAKNFANYGYYDLAHNSIVLLLNTTASSTAKELA------YSYEQSIGVTPSASYKIYNYTNKTVNVNQYMNE----LPLS------------------MLIYMATNGKYNNLASLPVGTKLEFT--------YA--GVT-YI---IAVSPTVKL--VGEL---LNPLYTANSKMLPGTNYAVGRSNI----------------TVAVYDNLITTTTSPFNFTLTYSSLAPA-----------------------------------------------------------------------LIYWFVIANTTYTNNGASTPTASFQAPPFKQYFPS----------------------NSTILYSAAPTKSSILMFNGQMNVT-AHE-NVTLTLQTGTNIYTSPNFNVTPPGNYTFSGKLG------------VGFNGFIYQNGSATLTATIFNGTINFFFSST-----------------------------------------------------GQKAAFTFFLVPIVPINL-GD--N-------NGATV-----------IYNGVSLNTGFPQVVVMFNITGNFTKSGSN----------YLLYGSVYEAELKPLGSTQLQKLAGATDSTQFVGNLISSASSPLVSYFNYGESTTTITGTSLSFTVLMPLKFIVE-R-----L-GYIYLVTFHIWG--PSATVTVTGVDYHGTQIALGSFRAYVALPSF--YTLPKTPLVGLTCDN-MYTLAQVS-DAGSVLETSTANSNANNATVI---------GPYDLMSNAGLHVAIYNGSKLVKSGNLGLLPNATTAPITTTITLNGQTVALTYSSAPTAIYPVDFKF-------------------------EPGFSYSV------TTNVIYNTSIP-----------------------------TYVVTVYMPLKYILQTKIVMWYVS-PDYAAYFYYSSTG----QY----Q-TSN---------------------------V-T-----------------------LTF------------AN-VTPELVMP----------------------------------QVFPVGKLYMPFGINDPYYVFYSSISIG-PQSGV----IEAVENGFNVGNITSITVELNGMNESIV-----------LSPLNVSKLLISSNLGEVSQCSPL-----------------------------FTT-TL----FN-----------ISALASLLGLPNAAALNGSYLYVTYHDIISGAYV------------------------------TNRTLLVVGQFYV-M-PPTTPGS-VE--W---------------ILTAKYINAT-TGIPVEISYAVVQQPSAKVVDINAANASITQIQVTGVKIVSKYATVTVMYNPSNA--STIVY------------------------------------------------MNGMFVASYGGNLISSLSETST---FGVY--YG----AVVNLYVATGTLSS----------PNGTMYVV----------------------------LGSH------------KVAVG----------TANLYTYA-------------------------------------------------------------------------------------------------------GYHFGPYTALPLVSNVTFTVQDPVTHATLTGQTTLGAFNNTPIRLAPLGVSIPQTAQYKVFYYYSTPLVLSPTSQYIVLSVTSVISYPYPFYIETVSFLGYNVTTGTPVPGTPAFQTVYSPSLGPGVVLQVPVQSYQFISLSTPSEPHTVVMFAVPFAGGPAISLYPTFLVYANVTAISS 
 
SQIRHYKWEVEYMFWAPNC---------------------------NENIVMGIN---------G--Q-----FPGPTIRANAGDSVVVELTNKLHTEGVVIHWHGILQRGTPWADGTAS-I-----SQ--CAINPGETFFYNFTVD---N-------PGTFFYHGHLG-M-QRSAGLYGSLIVDPPQGKK--EPFHYDGEINLLLSDWWHQSIHKQEVGLSSK---------------PIRW-IGEPQTILLNGRGQFDCSIAAKYDSNLEPCKLKGSESCAPYIFHVSPKKTYRIRIASTTAL-AALNFAIGNHQLLVVEADGNYVQPFYTSDIDIYSGESYSVLITTDQNPSENYWVSVGTRARHPNTPPGLTLLNYLPNS---------------------------------------------------------------------------------------------------------------------------VSKL-P-TS----------------------------------------------------------------------------------PPPQT--------------------------------------------------------------------------------------------------------------PAW--DDF------------------DRSK--NFTYRITAA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGSPKP-----------------------------------------------PVKFNRRIFLLNTQNV-------------------IN-----------------------------------GYVKWAINDVSLALPPTP----Y---LG--------AMKYNLLHAFDQNPPP----------EVFPEDYDIDTPPTNEKTRIGNGV--------------YQFKIGEVVDVILQNANMMKENLSETHP---WHLHGHDFWVLGYGDGKFSAEEESSLNLKNPPLRNTVVI-------------------------FPYGWTAIRFVA-------D--NPGVWAFHCHIEPHLHMGMGVVFAEGVEKVGRIPTKALACGGTAKSLINNPKNP 
M-NKTLGLILTSVFLLSTLGIITGFVIPTQAANSNDAAIYTIPSVTSVSNTSNIVINLFFNATSNSTVGAQASAFNYGLAINYTLDAITFTVVLPS-GTSYPLIKLNAK--NFANYGYYDLAHNSIVLLLNTTASSTAKELAYSYEQSIGVTPSASYKIYNYTNKTVNVNQYMNELPLSMLIYMATNGKYNNLASLPVGTKLEFTYAGVTYIIAVSPT------VKLVGELLNPLYTANSKMLPGTNYAVGRSNITVA----V-------------------YDNLITTTTSPFNFTLTYSSLAPALIYWFVIANTTYTNN--------GASTPTASF----------------------QAPP---FKQYFPSNSTILYSAA-PTKSSILMFNGQMNVTAHENVTLTLQTGTNIYTSPNFNVTPPGNYTFSGKLGVGFNGFIYQNGSATLTATIFNGTINFFFSSTGQKAAFTFFLVPIVPINLGDNNGATVIYNGVSLNTGFPQVVVMFNITGNFTKSGSNYLLYGSVYEAELKPLGSTQLQKLAGATDSTQFVGNLISSASSPLVSYFNYGESTTTITGTSLSFTVLMPLKFIVERLGYIYLVTFHIWGPSATVTVTGVDYHGTQIALGSFRAYVALPSFYTLPKTPLVGLTCDNMYTLAQVSDAGSVLETSTANSNANNATVIGPYDLMSNAGLHVAIYNGSKLVKSGNLGLLPNATTAPITTTITLNGQTVALTYSSAPTAIYPV----DFKFEPGFSYSVTTNVIYNTSIPTYVVTVYMPLKYILQTKIVMWYVSPDYAAYFYYSSTGQYQTSNVTLTFANVTPELVMPQVFPVGKLYMPFGINDPYYVFYSSISIGPQSGVIEAVENGFNVGNITSITVELNGMNESIVLSPLNVSKLLISSNLGEVSQCSPLFTTTLFNISALASLLGLPNAAALNGSYLYVTYHDIISGAYVTNRTLLVVGQFYVMPPTTPGSVEWILTAKYINATTGIPVEISYAVVQQPSAKVVDINAANASITQIQVTGVKIVSKYATVTVMYNPSNASTIVYMNGMFVASYGGNLISSLSETSTFGVYYGAVVNLYVATGTLSSPNGTMYVVLGSHKVAVGTANLYTYAGYHFGPYTALPL----VSNVTFTVQ-DPVTHATLTGQTTLGAFNNTPI--RLAPLGVSIPQ-----------------------TAQYKVFYYYSTPLVLSPTSQYIVLSVTSVIS----YPYPFYIETVSFLGYNVTTG----------------TPVPGTPAFQTVYSPSLGPGVVLQVPVQSYQFISLSTPSEPHTVVMFAVPFAGGPAISLYPTFLV-------------YANVTAISS-------------------------- 
 
G-VEITEGVTVTAK-GNTE---------------------------------GNTADLAID--GDLSTYWE-SSNDYKWIEVDLGG--IYELSKIEIFNKDEAVYKYNIYASEDGENFNKI--AYKNND-----------NVSDSNGNMHTIDNVRAG-----------K-IRIDVVQNS--NSDRVNIAEINVFGKNTG---------ESLPEVKKIATSNFSETPWATEYEKFNSDSAYANEKTLNEIKNLVGRVIGREFKDKFIFEIRDQLNGNDVFEVSDSGDGKVLIKGNNGVSLASGFNYYLKNYCNVSYNPIMGSNLKMPETMPSVGERVVIDTPYEHRYALNFCTYSYTMSFWDWDQYEEFLDWCAMNGVNLVLDIIGQEEVLRRT-----------------------------------------------------------LNEFGYSDEEVKEFISGPA-YFA-WFYMQNMTGFGGPLP-----NDWFEQRAELGRKMHDRMQSFGINPVLQGYSGMVP--------RDFKEKNQ-E-AQTISQGGWCGFDRP----------------------------------------------------------------------------------------------------------DML-------KTYVN-----EGEA-------DYFQKVADVFYEKQKEVF-------------------------------------------GDV-TNFYGVDPFHEG--GNTGDLDNGKIYEIIQNKMIEHDND--AV------WVIQNWQGNPSN--NKLEGLTKKDQAMVL--------------------------------------DLFSEVSPDWNRLEERDL------PWI-------------WNMLH----------NFGGRMGMDAAPEK-------------LATEIPKALANSE---HMVGIG---ITPEAINTNPLAYEL----------LFDMAWTRDQINFRT--WTEDYIERRYGKTNKEILEAWNIILDTAYKKRNDYYQGAA------ESIIN-------------------ARPGF--GIKSASTWG--HSKIVYD----------------KSEFEKAIEIF-AKNYD--------------------EFKDS--------------DAFLYDFA--------DIL-----------------------------------------KQL---------------------------LANS------------------------A--Q-EYYEVMCNAYNNGNG-----EKFKFVSGKFLEL---------------------------IK---LQERVL--------------------------------------S---------TRPE------FLIGNW---------------IE--DARTMLKDSDDWTKDLFEFNARALV------TTWGSRNNADGGGLKDYSNRQWSGLTEDYYYARWEKWINGLQAELDGGAKAPNIDWFKMEYDWVNK------------KSDTDK--LYPTEASNENLGELAKIAMESYSVTNMD-- 
-MNKTL--GLILT-SVFLLSTLGIITGFVIPTQAANSNDAAIYTIPSVTSVSNTSNIVINLFFNATSNSTVGAQASAFNYGLAI--NYTLDAITFTVVLPSGTSYPLIKL-------NAKNFANYGYYDLAHNSIVLLLNTTASSTAKELAYSYEQ--SIGVTPSASYKIYNYTNKTVNVNQYMNELPLSM---------LIYMATNGKYNNLASLPVG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKLEFTYAGVTYIIAVSPTVKLVGELLNPLYTANSKMLPGTNYAVGRSNITVAVYDNLITTTTSPFNF-TLT-YSS--LA--PAL--IYWFV------IANTTY-TNN-GA------------------STPTASFQAPPFKQYFPSNSTILYSAAPT--------------KSSILMFNGQMNVTAHENVTLTLQTGTNIYTSPNFNVTPPGNYTFSGKLGVGFNGFIYQNGSATLTATIFNGTINFFFSSTGQKAAFTFFLVPIVPINLGDNNGATVIYNGVSLNTGFPQVVVMFNITGNFTKSGSNYLLYGSVYEAELKPLGSTQLQKLAGATDSTQFVGNLISSASSPLVSYFNYGESTTTITGTSLSFTVLMPLKFIVE--RLGYIYLVTFHIWGP-SA-TVTVTGVDYHGTQIALGSFRAYVALPSFY-TLPK-------------TPLVGLTCDNMYTLAQVSDAGSVLETSTANSNANNATVIGPYDLMSNAGLHV----AIYNGSKLVKSGNLGLLPNATTAPITTTITLNGQTVALTYS----------SAPTAIYPVDFKFEPGFSYSV-----TTNVIYNTSIPTYVVTVY---------MPLKYILQTKIVMWYVSPDYA----AYF--YY-SSTGQYQ---T--SN-VT-LT-------------FANVTPELVMPQVFPVGKLYMPFGINDPYYVFYSSISIGPQS----GVIEAVE--NGFNVGNITSITVELNGMNESIVLSPLNVSKLLISSNLGEVSQCSPLFTTTLFNISALASLLGLPNAAALNGSYLYVTYHDIISGAYVTNRTLLVVGQFYVMPPTTPGSVEWILTAKYINATTGIPVEISYAVVQQPSAKVVDINAANASITQIQVTGVKIVSKYATVTVMYNPSNASTIVYMNGMFVASYGGNLISSLSETSTFGVYYGAVVNLYVATGTLSSPNGTMYVVLGSHKVAVGTANLYTYAGYHFGPYTALPLVSNVTFTVQDPVTHATLTGQTTLGAFNNTPIRLAPLGVSIPQTAQYKVFYYYSTPLVLSPTSQYIVLSVTSVISYPYPFYIETVSFLGYNVTTGTPVP--GT-PAFQTVYSPSLGPGVVLQVPVQSYQFISLSTPSEPHTVVMF-----------------------------------------AVPFAGGPAISLYPTFLVYANVTAI-----------------------SS 
 
KTVTPEWQTV------EKKEQQGTVTIREEKG-V------------R-------YNQLSSTAQNDNAGKPALFEKKGLTVDANGNATVDLTFKDD--SEKGKSRFGVFLK-------------------FKDTKNNVFVGYDKD------------------------------------------------GWFWEYKSPT-------------TSTWY--------RG--SRVAAP--------------------------------------------E-T-GSTNR-L-----------SITLKSD-GQLNASNNDVNLFDTVTLPAAVNDHLKNEKK-------ILLKAGSYDDERTVVS----VKTDNQEETGPEVDDSKVTYDTIQSKVLKAVIDQAFPRVKEYSLNGHTLPGQVQQFNQVF--------INNHRITPEVTYKKINETTAEYLKLRDDAHLINAETV----------------------------------------------------RLQVVDNQLHFDVTKIVNHNQVTPGQKIDDERK-----------------LLSSISFLGNALVSVSSDQTGAKFDGATSNNTHVS-------GDDHIDVTN--PKDLAKGYYGFVSTDKLAAGVWSNSQNSYGGGSNDWTRLTAYKETVGNANYVGIHSSEWQWEKAYKGIVFPEYTKELPSAKVVITEDANADKKVDWQDGAIAYRSINNPQGWKKVKDITAYRIANFGSQAQNPFLTLDGIKKINLHTDGLGQGVLLKGYGSEGHDSGHLNYADIGKRIGGVEDFKTLIEKAKKYGAHLGIHVNASET--------------YPESKYFNEKILRKNPDGSYSYGWNWLDQGINIDA-------AYDLAHGRLARWEDLKKKLGDGLDFIYVDVWGNGQSGD-----------------NGAWATHVLA---KEINKQGWRFAIEWGHGGEYDSTFHHWAADLTYGGYTNKGINSAITRFIRNHQKDAWVGDYRSYGGAANYPLLGGYSKDFEGWQGRSDYNGYVTNLFAHDVTKYFQHFTVSKWENGTPVTTDNGSTYKWTPERVELVDADNNKVVVTRKSNDVNSPQYRERTVTLNGRVIQDGSAYLT----PWNWDANGKKLSTDKEKYYFNTQAGATTWTLPSDWAKSKVYLYKLTDQGKTEEQELTVKDGKITLDLL-----------------------------------------------------------------------------------ANQPYVLYRSKQTNPESWSE-------------------G--HIYDQGFNSGTLKHWTISGDASKAEIV------------------------------------------KSQGANDLRIQ---------GNKEKVSLTQKLTGLKPNTKYAVY-VGVDNRSNAKASITVNTGEKEVTTYTNKSLALNYVKAYAHNTRRNNATVDDTSYFQN--Y-AFFTTGSDVSNV--------TLTLSREAGDEA----------------------TYFDEIRTFENNSSYGDKHDTGKGTFKQDFE----------NVAQGIFPFVVGGVE-------------------------------GVEDNRTHLSEKHDPYTQRGWNGKKVDDVIEGNWSLKTNGLVS------------------------------------------------------------------------------RRNLVYQTIPQNFRFEAGKTYRVTFEYEAGS-DNTYAFVVGKGE-----FQSGRRGTQASNLEHELPNTWTDSKKAKKAT---FL-VTGAETGDTWVGIYSTGNASNTRG------------------------DSGGN-ANFRGYN--------DFDNLQIEEITLTGKLTENALKNYLPTVAKEAVFNLSQADDDISVEEARAEIAKI-------------------------------------------------------- 
----------MNKTLGLILTSVFLLSTLGIITGFVIPTQAANSNDAAIYTIPSVTSVSNTSNIVINLFFNAT-----------------------SNSTVGAQASAFNYGLAINYTLDAITFTVVLPSGTSYPLIKLN------AKNFANYGYYDLAHNSIVLLLNTTASSTAKELAYSYEQSIGVTPSASYKIYNYTNKTVNVNQYMNELPLSMLIYMATNGKYNNLASLPVGTKLEFTYAGVTYIIAVSPTVKLVGELLNPLYTANSKMLPGTNYAVGRSNITVAVYDNLITTTTSPFNFTLTYSSLAPALIYWFVIANTTYTNNGA--------------STPTASFQA--------------PPFKQYFPSN------------------------------------------------------STILYSAAPTKSSILM-----------------------------FNGQMNVTAHENVTLTLQTGTNIYTSPNFNVTPPGNYTFSGKLGVGFNGFIYQNGSATLTATI----------------------FNGTINFFFSSTGQKAAFTFFLVPI--VPINL-----GDNNGATVIY-----NGVSLNTGFPQV----VVMFNITG-N-FTKS----GS---------------------------------NYLLYGSVYEAELKPLGS-----------------------------------------------------------------------------------------------------------------------------------------TQLQKLAGATDSTQFVGNLISSASSPLVSYFNY----------------GESTTTITGTSLSFTVLMP------------LKF-----------IVERLGYIYLVTFHIWGPSATVTVTGVDYHGTQIALGSFR-----------AYV------------------------------ALPSF-------Y--TLPK-----------------------------------TPLVGLTCD-------------NMYTLAQ-----VSDAGSVLETS-TANSNANNA-------T--V----IGPYDLMSNAGLH-----------------------------------------------------------VAIYNGSKLVKSGNLGLLPNATTAPITTTITLNGQTVALTYSSAPTAIYPVDFKFEPGFSYSVTTNVIYNTSIPTYVVTVYMPLKYILQ--------------TKIVMWYVSPDYAAYFYYSSTGQYQTSNVTLT-----------------FANVTPELVMPQVFPVGKLYMPFGINDPYYVFYSSISIGPQSGVIEAVENG--FNVGNITSITVELNG------------------MNESIV-----LSPLN-------VSKLLISSNLGEV-----SQC--SP-----LFTTTLFNISALASLLGLPNAAALNGSYLYVTYHDI-----ISGAYVTNRTLLVVGQFYVMPPTTPGSVEWILTA-------------------KYINATTGIPVEISYA---------VVQQPSAKVVDINAANASITQIQVTGVKIVSKYATVTVMYNPS--------------------NASTIVYMN--GMFVASYGGNLISSLSETSTFGVYYGAVVNLYVATGTLSSPNGTMYVVLGSHKVAVGTANLYTYAGYHFGPYTALPLVSNVTFTVQD----------------------PVTHATLT-----GQTTLGAFNNTPIRLAPLGVSI--------------PQTA-QYKVFY-YYSTPLVLSPTSQYI---VLSVTSVISYPYPFYIETVSFLGYNVTTGTPVPGTPAFQTVYSPSLG-----------------------------------------------------PGVVLQVPVQSYQFISLSTPSEPHTVVMFAVPFAGGPAISLYPTFLVYANVTAISS 
 
EPTCNTPSNRACWSDGFDINTDYEVSTPDTGVTQSYVFNLTEVDNWMGPD------------------G-------VVKEKVMLING----------------NIMGPNIVANWGDTVEVTVINNLVTNGTSIHWHGIHQKDTNLHDGANG-V-T---EC--PIPPKGGQRTYRWRAR---Q-------YGTSWYHSHFS-A-QYGNGVVGTIQIN--GPAS----LPYDIDLGVFPITDYYYRAADDLV--------------HFTQ-NNA-PPFSDNVLINGTAVNPNTGEGQYANVTLTPGKRHRLRILNTSTE-NHFQVSLVNHTMTVIAADMVPVNAMTVDSLFLAVGQRYDVVIDASRAPDNYWFNVTFGGQAACGGSLNPHPAAIFHYAGA--------------------------------------------------------------------------------------------------------------------P------GGLP-T-DE---------------------------------------------------------------------------------GT--P--------P----------------------------------------------------------------------------------------------------VDH----QCLD--------TLDVRPVV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRSVPVNSF-------------------------------------VKR---------PDNTLPVALDL-------------T-----G--------------------------------T--PL-FVWKVNGSDINVDWGKP--------IID--------YILTGNTSYP-VSDNI------------VQ-------------VDAV-DQWTYWLIENDPEGPFSLPHP---MHLHGHDFLVLGRSPDVPAASQQRFVFDPAVDLARLNGDNPPRRDTTML------------------------PAGGWLLLAFRTDN----------PGAWLFHCHIAWHVSGGLSVDFLERPADLRQRISQEDEDDFNRVCDEWRAYWPTNPYPKIDSGL 
-------------------------------MNKTLGLILTSV-FLLSTLGIITGFVIPTQAANSNDAAIYTIPSVTSVSNTSNIVINLFFNATSNSTVGAQASAFNYGLAINYTLDAITFTVVLPSG-TSYPLIKLN-A-KNFANYGYYDLAHNSIVLLLNTTASSTAKELAYSYEQSIGVTPSASYKIYNYTNKTVNVNQYMNELPLSMLIYMATNGKY-NNLASLPVGTKLEFTYAGVTYIIAVSP-TVKLVGELLNPLYTANS-KML-PGTNYAVGRSNITVA------VYDNLITTTTSPFNFTLTYSSLAPALIYWFVIANTTYTNN--------GASTPTASF---------------------QAPP-------FKQYFPSNSTILYSAAPTKSSILMFNGQMNVTAHENVTLTLQTGTNIYTSPNFNVTPPGNYTFSGKLGVGFNGFIYQNGSATLTATIFNGTINFFFSSTGQKAAFTFFLVPIVPINLGDNNGATVIYNGVSLNTGFPQVVVMFNITGNFTKSGSNYLLYGSVYEAELKPLGSTQLQKLAGATDSTQFVGNLISSASSPLVSYFNYGESTTTITGTSLSFTVLMPLKFIVERLGYIYLVTFHIWGPSATVTVTGVDYHGTQIALGSFRAYVALPSFYTLPKTPLVGLTCDNMYTLAQVSDAGSVLETSTANSNANNATVIGPYDLMSNAGLHVAIYNGSKLVKSGNLGLLPNATTAPITTTITLNGQT---VALTYSSAPTAIYPVDFKFEPGFSYSVTTNVIYNTSIPTYVVTVYMPLKYILQTKIVMWYVSPDYAAYFYYSSTGQYQTSNVTLTFANVTPELVMPQVFPVGKLYMPFGINDPYYVFYSSISIGPQSGVIEAVENGFNVGNITSITVELNGMNESIVLSPLNVSKLLISSNLGEVSQCSPLFTTTLFNISALASLLGLPNAAALNGSYLYVTYHDIISGAYVTNRTLLVVGQFYVMPPTTPGSVEWILTAKYINATTGIPVEISYAVVQQPSAKVVDINAANASITQIQVTGVKIVSKYATVTVMYNPSNASTIVYMNGMFVASYGGNLISSLSETSTFGVYYGAVVNLYVATGTLSSPNGTMYVVLGSHKVAVGTANLYTYAGYHFGPYTALPL-----VSNVTFTVQ--DPVTHATLTGQTTLGAFNNT----PIRLAPLGVSIPQTAQYKVFYYYSTPLVLSPTSQYIVLSVTSVI--SYPYPFYIETVSFLGYNVTTG--------------------------TPVPGTPAFQTVYSPSLGPGVVLQVPVQSYQFISLSTPSEPHTVVMFAVPFAGGPAISLYPTFLV-------------YANVTA-ISS------------------------------------ 
 
(a)Residue pairs that are structurally aligned by TM-align program are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade.(more about the colors used)
(b)Ranking of proteins is based on TM-score of the structural alignment between Model1 and the PDB structures in our template library.
(c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the model.

  Function Prediction

  Predicted EC Numbers

RankTM-scoreRMSDaIDENaCov.EC-ScorePDB
Hit		EC No.
10.7879 1.38 0.06 0.800.58561kcwA 1.16.3.1
 
20.2744 4.51 0.10 0.310.22602ve0A 1.10.3.2
 
30.2740 4.57 0.10 0.310.22002h5uA 1.10.3.2
 
40.2761 4.62 0.08 0.310.20791gycA 1.10.3.2
 
50.2955 9.55 0.05 0.460.20083ffzB 3.4.24.69
 
(a)Ranking is based on EC-score, which is a confidence score for the Enzyme Classification (EC) Number prediction.
(b)RMSDa is the RMSD between models and the PDB structure in the structurally aligned regions by TM-align.
(c)IDENa is percentage sequence identity in the structurally aligned region.
(d)Cov. represents the coverage of the alignment and is equal to the number of structurally aligned residues divided by length of model.
(e)EC-Score is defined based on the C-score of the structure prediction and similarity of the model with known enzyme structures, as identified using both global and local structural alignment programs. The global similarity score uses TM-score, IDENa,RMSDa and Cov. of the structural alignment by TM-align, while the local match compares the structural and chemical similarity of local spatial motifs in the model with known catalytic site of enzymes. A prediction with a EC-score >1.1 signifies a prediction with high confidence (upto 3 digit numbers of EC) and vice versa (For details, see Ambrish, Kucukural and Zhang,Large scale benchmarking of protein function prediction using predicted protein structures, 2009, submitted).

  Predicted GO terms

RankTMscoreRMSDaIDENaCov.PDB
Hit		Fh-ScoreAssociated GO Terms
10.7863 1.39 0.06 0.802j5wA 0.58 GO:0004322 GO:0005507 GO:0043169 GO:0006825 GO:0006879 GO:0007568 GO:0007584 GO:0042221 GO:0055072 GO:0055114 GO:0005576 GO:0005615 GO:0005623 GO:0005886 GO:0031225 GO:0046658
20.286310.00 0.06 0.462uzaB 0.21 GO:0005506 GO:0009055 GO:0016903 GO:0030976 GO:0043169 GO:0050662 GO:0051536 GO:0008152
30.2708 4.68 0.08 0.311zpuF 0.20 GO:0004322 GO:0005381 GO:0005506 GO:0005507 GO:0005515 GO:0015082 GO:0022892 GO:0043169 GO:0006826 GO:0006827 GO:0015674 GO:0033215 GO:0046688 GO:0055072 GO:0055114 GO:0005623 GO:0005886 GO:0016021 GO:0033573 GO:0044459
40.2942 9.76 0.05 0.471t36G 0.20 GO:0004086 GO:0004088 GO:0005515 GO:0005524 GO:0030145 GO:0030554 GO:0043169 GO:0006221 GO:0006525 GO:0006526 GO:0008652 GO:0009058 GO:0009165 GO:0009308 GO:0009309 GO:0009987 GO:0019752 GO:0044249
50.2864 9.87 0.05 0.462e1qD 0.20 GO:0004854 GO:0004855 GO:0005506 GO:0009055 GO:0030151 GO:0043169 GO:0050660 GO:0050662 GO:0051537 GO:0001894 GO:0007595 GO:0009653 GO:0009887 GO:0009987 GO:0010044 GO:0030154 GO:0030856 GO:0032504 GO:0045453 GO:0048856 GO:0055114 GO:0060249 GO:0060429 GO:0005622 GO:0005623 GO:0005737 GO:0005777 GO:0005829 GO:0043229
60.2766 4.80 0.07 0.312q9oB 0.19 GO:0005507 GO:0008471 GO:0043169 GO:0006725 GO:0009056 GO:0009808 GO:0009987 GO:0019439 GO:0030243 GO:0030245 GO:0042219 GO:0043283 GO:0043285 GO:0046274 GO:0055114 GO:0005576 GO:0043245
70.2823 4.64 0.06 0.321asqB 0.19 GO:0005507 GO:0008447 GO:0043169 GO:0055114 GO:0005576
80.2559 8.90 0.07 0.383ddgA 0.19 GO:0004559 GO:0004572 GO:0008270 GO:0030246 GO:0043169 GO:0006013 GO:0006066 GO:0009987 GO:0000139 GO:0005622 GO:0005623 GO:0005737 GO:0005783 GO:0005794 GO:0005795 GO:0012505 GO:0016020 GO:0016021 GO:0043229 GO:0044444
90.2870 9.27 0.04 0.441ofeB 0.19 GO:0005506 GO:0005515 GO:0015930 GO:0016041 GO:0043169 GO:0051538 GO:0006536 GO:0006537 GO:0006541 GO:0008652 GO:0009058 GO:0009308 GO:0009309 GO:0009987 GO:0019752 GO:0044249 GO:0055114
100.2756 9.82 0.05 0.442e3tB 0.18 GO:0004854 GO:0004855 GO:0005506 GO:0009055 GO:0030151 GO:0043169 GO:0050660 GO:0050662 GO:0051537 GO:0055114 GO:0005622 GO:0005623 GO:0005737 GO:0005777 GO:0043229 GO:0044444

Consensus Prediction of Gene Ontology terms 
Molecular Function  Biological Process Cellular Location
GO termGO-Score  GO termGO-Score GO termGO-Score
GO:00038240.233  GO:00081520.233  GO:00056230.188
GO:00054880.233  GO:00099870.175  GO:00444640.188
GO:00431690.233  GO:00551140.174  GO:00160200.115
GO:00431670.233  GO:00650080.098  GO:00312240.115
GO:00469140.233  GO:00422210.098  GO:00444250.115
GO:00468720.233  GO:00508960.098  GO:00055760.097
GO:00164910.195  GO:00425920.098  GO:00058860.096
GO:00055070.117  GO:00650070.098  GO:00444590.096
GO:00055060.098  GO:00300050.079  GO:00057370.092
GO:00167220.079  GO:00512340.079  GO:00444240.092

(a)Ranking in the first table is based on a function prediction score (Fh-score), which is calculated based on the C-score of the structure prediction and the TM-score, IDENa, RMSDa and Cov. of the structural alignment by TM-align between the predicted model and the PDB structures (For details, see Ambrish, Kucukural and Zhang,Large scale benchmarking of protein function prediction using predicted protein structures, 2009, submitted).
(b)RMSDa is the RMSD between models and the PDB structure in the structurally aligned regions by TM-align.
(c)IDENa is the percentage sequence identity in the structurally aligned region.
(d)Cov. represents the coverage of the alignment and is equal to the number of structurally aligned residues divided by length of model.
(e)A consensus prediction of GO terms is derived from the structural analogs that have an Fh-score of >=1.0. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on the Fh-score of the template from which the GO term is derived. A prediction with a GO-score >0.5 signifies a prediction with high confidence and vice versa.


  Predicted Binding Site


Binding site residues in the model:
ASN:157  VAL:194  THR:196  LYS:197  LEU:198  THR:257  THR:258  
SER:259  PRO:260  PHE:261  ASN:262  PHE:263  THR:264  LEU:265  
THR:266  TYR:267  SER:268  PHE:278  ILE:280  TYR:285  ASN:287  
ASN:288  THR:292  PRO:293  THR:294  ALA:295  SER:296  PHE:297  
TYR:314  
Identified analogs with similar binding site:

RankPDB
Hit		TM-scoreRMSDaIDENaCov.BS-scoreDownload
Complex		Binding site residues on the predicted model
12e1qA0.2779 9.79 0.04 0.44 0.17Download157,194,196,197,198,257,258,259,260,261,262,263,264,265,266,267,268,278,280,285,287,288,292,293,294,295,296,297,314
22uvbD0.2369 9.42 0.05 0.36 0.17Download14,15,16,17,18,36,37,44,45,46,47,48,207,216,220,240,241,242,244,245,246,247,248,249,250,251,303,304,305,306,307,308,309,310
32e1qA0.2779 9.79 0.04 0.44 0.17Download60,61,62,63,116,117,184,223,224,766,767,768,769,770,771,772,773,774,783

(a)Ranking of the analogs in the table is based on their BS-score. BS-score is calculated by first finding the structural analogs of the predicted model based on their TM-score, IDENa and Cov. of the structural alignment. The ligand(s) in the analog structure are then transferred onto the model and the fitness of the ligand-model complex (BS-score) is calculated by comparing the local structure and sequence similarity in the binding site region. (For detail, see Kucukural, Szilagyi, Ambrish, and Zhang, Template based ligand binding site prediction on modeled protein structure, 2009, in preparation).
(b) A BS-score of >0.5 signifies a binding site prediction with high confidence and vice-versa.
(c)RMSDa the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the model.
(f)The image shows the ligand-protein complex with the best BS-score. The ligand is depicted in magenta colored ball & stick, the predicted binding site residues interacting with the ligand are shown as transparent green spheres, while the N & C terminus in the model are marked by blue and red spheres respectively.



 Please cite following articles when you use the I-TASSER server:
1.Yang Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9:40 (2008).
2.Yang Zhang. Template-based modeling and free modeling by I-TASSER in CASP7. Proteins, 8: 108-117 (2007).
3.Sitao Wu, Jeffrey Skolnick, Yang Zhang. Ab initio modeling of small proteins by iterative TASSER simulations. BMC Biology, 5:17 (2007).