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I-TASSER results for job id S34345

Submitted Sequence

>your_protein
MTDVTIKTLAAERQTSVERLVQQFADAGIRKSADDSVSAQEKQTLIDHLNQKNSGPDKLT
LQRKTRSTLNIPGTGGKSKSVQIEVRKKRTFVKRDPQEAERLAAEEQAQREAEEQARREA
EESAKREAQQKAEREAAEQAKREAAEQAKREAAEKDKVSNQQDDMTKNAQAEKARREQEA
AELKRKAEEEARRKLEEEARRVAEEARRMAEENKWTDNAEPTEDSSDYHVTTSQHARQAE
DESDREVEGGRGRGRNAKAARPKKGNKHAESKADREEARA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTDVTIKTLAAERQTSVERLVQQFADAGIRKSADDSVSAQEKQTLIDHLNQKNSGPDKLTLQRKTRSTLNIPGTGGKSKSVQIEVRKKRTFVKRDPQEAERLAAEEQAQREAEEQARREAEESAKREAQQKAEREAAEQAKREAAEQAKREAAEKDKVSNQQDDMTKNAQAEKARREQEAAELKRKAEEEARRKLEEEARRVAEEARRMAEENKWTDNAEPTEDSSDYHVTTSQHARQAEDESDREVEGGRGRGRNAKAARPKKGNKHAESKADREEARA
Prediction	CCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCSSSSSSSSSSSSCCCCCCCCSSSSSSSSCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCHHHCC
Conf.Score	9623199999997979999999999839999988752999999999999984599877426654468888327899860487898743330489941000322312000322445422047665121111788886776515556554376775254444775321002212111012036666668899988889998888898661888725777677501268886555224423598321336506788788977776557432055553054219

Top 5 Models predicted by I-TASSER


Download Model 1	Download Model 2	Download Model 3	Download Model 4	Download Model 5
C-score=-3.99	C-score=-4.35	C-score=-5	C-score=-3.66	C-score=-4.92

Estimated accuracy of Model1: 0.29±0.09 (TM-score) 15.9±3.2Å (RMSD) (Read more about C-score of generated models)

Top 10 templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov.

Norm.
Z-score

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCSSSSSSSSSSSSCCCCCCCCSSSSSSSSCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCHHHCC
MTDVTIKTLAAERQTSVERLVQQFADAGIRKSADDSVSAQEKQTLIDHLNQKNSGPDKLTLQRKTRSTLNIPGTGGKSKSVQIEVRKKRTFVKRDPQEAERLAAEEQAQREAEEQARREAEESAKREAQQKAEREAAEQAKREAAEQAKREAAEKDKVSNQQDDMTKNAQAEKARREQEAAELKRKAEEEARRKLEEEARRVAEEARRMAEENKWTDNAEPTEDSSDYHVTTSQHARQAEDESDREVEGGRGRGRNAKAARPKKGNKHAESKADREEARA

1nd9A

1.00

0.17

3.93

Download

-TDVTIKTLAAERQTSVERLVQQFADAGIRKSADDSVSAQEKQTLIDHLN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1ykdA

0.09

0.22

0.98

1.19

Download

VTEGFENILQEMLQSITLKTGELLEGDRSLEIRPFDFYHDPRSIFAQKQEKITGYRTYTML------ALPLLSEQGRLVAVVQLLNKLKPYSPPDALLAERIDNQGFTSADEQLFQEFAPSIRLILESSRSFYIATQKQRAAAAMMKAVKSLSQSSLDDRDRHELWTKITQDNGSTKELRVPIGKGFAGIVAASGQLYDHPDSATAKQIDQQNGYRTCSLFNGDQELIGVTQLVNKKKTGEFPPYNPETWPIAPECFQASFDRNDEEFMEAQNAQLFATV

1nd9A

1.00

0.17

3.93

Download

-TDVTIKTLAAERQTSVERLVQQFADAGIRKSADDSVSAQEKQTLIDHLN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1uaaA

0.11

0.15

0.91

1.15

Download

YGAEELIAHHFVNKTQSRVFEKFLMQNRIPYKISGGTSFFSRKDLLAYLRVLTNPDDDSAF------------------------LRIVNTPKREIGPATLKKLGEWAMTRNKSMFTASFDMGLSQTLSGRGYEALTRFTHWLAEIQRLAEREPIAAVRDLIHGMDYESWLYETSPSPKAAEMRMKNVNQLFSWMTEMLEGSELDLTQVVTRFTLRDMMEREEELDQVQLMTLHASKGLEGFLPHQSSIDEDNIDCKERRQYGELVRPEPSRFLLELPQD

1nd9A

1.00

0.17

2.05

Download

-TDVTIKTLAAERQTSVERLVQQFADAGIRKSADDSVSAQEKQTLIDHLN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1w9rA

0.17

0.12

0.42

1.56

Download

----------------------------------------------------------------------------------------------SHMPEKKVAEAEKKVEEAKKKAEDQKEEDRRNYPTNTYKTLELEIAESDVEVKKAELELVKEEAKEPRN-------EEKVKQAKAEVESKKAEATRLEKIKTDRKKAEEEAKRKAAEEDKVKEKP-------------------------------------------------------------

1nd9A

1.00

0.17

2.86

Download

-TDVTIKTLAAERQTSVERLVQQFADAGIRKSADDSVSAQEKQTLIDHLN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1dqsA

0.11

0.19

0.97

1.14

Download

WRNYVAKDLISDCSSTTPSFEEAFRKRAAEITPSPRLSRQTKADIEDWMLSQNPPCGRDTVVMRGVRYVQVDSSIGGKTAIDTPLGKNLIGAIWQDLEFLETLPVREFIEEEFTALEENAETILKAVRRRFEGTEEILKARILASARHKAYVVSADEREGGLRNLLNEAILTPQILHGECVAIGMVKEAELARHLGILKGVAVSRIVKCLAAYGLPTSLKDARIRKLTA---------GKHCSVDQLMFNMALDKKNDGPKKKYETRASVVANEDIRVVL

1m5yA

0.06

0.25

0.95

1.14

Download

VDKVAIANIAKQNNMTLDQMRSRLAYDGLNYNTNQIRKEMIISEVRNNEVRRRITILPQEVESLAQ---------QVTELNLSHILIPLPENPTSDQVNEAESQARAIVDQARNGADFGKLAIAHSADQQALNGGQMGWGRIQELPGIFAQALSTAKKRGESKNISVTEVHARHILLKPSPIMTDEQARVKLEQIAADIKSGKTTFAAAAKEFSQDPGSA-----NQGGDLGWATPDIFDPAFRDALTRLNKGQMSAPVHSSFVDRAYRMLMNRKFSEES

4hb1A

0.16

0.05

0.16

1.36

Download

------------------------------------------------------------------------------------------------------------------------------------------------------------E-----ELLKQALQQAQQLLQQAQELAK----EELLKQALQQAQQLLQQAQEL-----------------------------------------------------------------------

(a)	All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)	Rank of templates represents the top ten threading templates used by I-TASSER.
(c)	Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)	Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)	Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)	Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)	Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)	The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
	1: HHSEARCH 2: PROSPECT2 3: HHSEARCH I 4: PROSPECT2 5: FUGUE 6: HHSEARCH II 7: HHSEARCH II 8: PROSPECT2 9: PROSPECT2 10: HHSEARCH II

10 proteins in PDB which are structurally closest to the first I-TASSER model (identified by TM-align)

Rank	TM-score	RMSD^a	IDEN^a	Cov.	PDB Hit
1	0.7511	3.95	0.07	0.92	1ykdA Model1

2	0.4731	5.50	0.06	0.72	2veaA Model1

3	0.4384	6.04	0.04	0.72	2cn2A Model1

4	0.4362	5.90	0.05	0.72	1sqjA Model1

5	0.4255	6.17	0.05	0.72	1nr0A Model1

6	0.4219	6.25	0.06	0.72	1ea0A Model1

7	0.4203	5.81	0.03	0.68	1pguA Model1

8	0.4177	5.41	0.08	0.63	3c2wA Model1

9	0.4013	6.04	0.08	0.67	1t3tA Model1

10	0.3979	6.35	0.05	0.69	2uv9A Model1

Structural alignment using TM-align
VTEVEQKLQIVHQTLSMLDSH------GFENILQEMLQSITLKTGELLG-ADRTTIFLLDEEKQELWSIVAAGEGDRSLEIRIPADKGI--AGEVATFKQVVNIPFDFYHDPRSIFAQKQEKIT-----------GYRTYTMLALPLLSEQGRLVAVVQLLNKLKPYSPPDALLAERIDNQGFTSADEQLFQEFAPSIRLILESSRSFYIATQKQRAAAAMMKAVKSLSQSSLDLEDTLKRVMDEAKELMNADRSTLWLIDRDRHELWTKITQDNGSTKELRVPIGKGFAGIVAASGQK-LNIPFDL-YDHPDSATAKQIDQQNGYRTCSLL-CMPVFNGDQELIGVTQLVNKKKTGEFPPYNPETWPIAPECFQASFDRNDEEFMEAFNIQAGVALQNAQLFATV ---------------------MTDVTIKTLAAERQTSVERLVQ-QF---ADAG-------------------IRKSADDSV--------SAQ------------------------EKQTLIDHLNQKNSGPDKLTLQRKTRSTLNIPGTGGKSKSVQIEVRKKRTFVKRDPQEAERLAAEEQAQREAEEQARREAEESAKREAQQKAEREAAEQAKREAAEQAKREAAEKDKVSNQQDD----------------M-T---------KNAQAEKARREQEAAELKRKAEEEARRKLE-EEAR----RV-AEEARRMAEENK--WTDNAEPTEDSS-------DYHVTTSQHARQAEDESDREVEGGRGRGRNAKAARPKKGNKHAESKADREEARA---------

TVQLSDQSLRQLETLAIHTAHLIQPHGLVVVLQEPDLTISQISANCTGILGRSPEDLLGRTLGEVFDSFLTAGQISSLNPSKLWARVMDFVIFDGVFHRNSDGLLVCELEPAYTSDNLPFLGFYHMANAALNRL----------NLRDFYDVIVEEVRRMTGFDRVMLYRFDENNHGDV---IAEDKR-DDMEP-YLGLHYPESDIPQPARRLFIHNPIRVIPDVYGVAVPLTPAVNPSTNRAVDLTESILRSAYHCHLTYL--------KNMGVGASLTISLIK-DGHLWGLIACHH------------Q--T-PKVIPFELRKACEFFGRVVFSNISAQEDTETFDYRVQLAEHEAVLLDKMTTAADFVEGLTNHPDRLLGLTGSQGAAICFGEKLILVGETP---DEKAVQYLLQWLENRE--VQ-DVFFTSSLSQIYP-DAV--------NFKSVASGL-LAIPIARHNFLLWFRPEVLQTVNWGGDPNHAYEATQKIELHPRQSFDLWKEIVRL-----------------------QSLP-WQSVEIQSALALKKAIVNLILRQAEEHHHHHH --------------------------------------------------------------------------------------------------------------------------------------MTDVTIKTLAAERQTSVERLVQQFAD-AGIR--------------KSADDSVSAQEKQTLIDHLNQ--------------------------------------------------------------KNSGPDKLTLQRK-TRSTLNIPGTGGKSKSVQIEVRKKRTFVKRDPQEAERLAAEEQAQREAEEQARREAEESAKREAQQKAEREAAEQAKREAAEQAKREAAEKDKVSNQQD---------------DMTK---NAQA----EKARRE-QE--AAELKRK-AEE-EARRKLEEEARRVAEEARRMAEENKWTDNAEPTEDSSDY------H-VTTSQHA-------------------------------------RQAEDESDREVEGGRGRGRNAKAARPKKGNKHAESKADREE-AR--A-------------

VTSVPYKWDNVVIGGGGGFPGI---VFNETEKD-LIYARADIGGAYRWDPSTETWIPLLDHFQDEYSYYGVESIATDPVDPNRVYIVAGYTNDWLPNGAILRSTDRGETWEKTILPFKGGNPGRSGERLAIDPN-DNRIL---YLGTRCGNGLWRSTDYG-----VTWS---KVESFP----NPGTIIGVVWVVFDKSSSTPGNPTKTIY-------------VGVADKNESIYR-ST-DGGV--TWKAVPGQPKGLLPHHGVLASNGLYITYGDGKGQVWKFNTRTGEWIDITPIPYSSSDNRFCFAGLAVDRQNPDIIVTSNAWWPDEYIFRSTDGGATWKNIWEWGYPERILHYEIDISAAPWLDWGTEKQLPEINPKLGWIGDIEIDPFNSDRYVTGATIYGCDNLTDWDRGGKVKIEVKATGIEECAVLDLVSPPEGAPLVSAVGDLVGFVHDDLKVGPKKHVPSYSSGTGIDY-----------------AELVPNFALVAKAVKKISFSYDGGRNWFQPPNE--------------APNSVGG-GSVAVAADAKSVIWTPENASPAVTTDNGNSWKVCTNLGGAVVASDRVNGKKFYAFYNGKFYISTDGGLTFTDTKAPQLPKSVNKIKAVPGKEGHVWLAAREGGLWRSTDGGYTFEKLSNVDTAHVV--------GFGKAAPGQDYAIYITGKIDNVLGFFRSDDAGK-----TWVRINDDEHGYGAVDTAITGDPRVYGRVYIATNGRGIVYGEPAS----------- ------MT--------------DVTI-K-----TLAAER-------QT------------------------SVER--------------------------------------------------LVQQFAD-AGIRKSADDSVSAQ-EKQTLI-----DHLNQKN--SGPD-----KLTLQRKTRSTL--------------------NIPGTGGKSKSVQIEV-----RKKRTFVKRDPQEAERLAAEEQAQ--------------RE-A------EEQ-----------A---------------RR---------EA---------E------------------------------------------------------ESA--------KRE--AQQ----------------KAEREA------------------------A--E------QAKREA------------AEQAKREAAEKDKVSNQQDDMTKN--------------------------AQAEKARREQEAAELK-----RKAEEE-------ARRKLEEEA-----------------RRV-------------A-------------------------EE--------------A-R--R-MAE------ENKWT--D-NAEPTEDSSDYHVTTS---------QHAR-------QAEDESDREVEGGRGRGRNAKA-------A---------------RPK--KGNKHA----ESKADREEARA

YEFKNVAIGGGGYI------TGIVAHPKTKDLLYAR--TDIGGAYRWDAGTSKWIPLNDFIEAQDMNIMGTESIALDPNNPDRLYLAQGRYVGDEWAAFYVSEDRGQSFTIYESPFPMGANDMGRNNGERLAVNPFNSNEVWMGTRTEGIWKSSDRAKTWTNVTSIPDAFTNGIGYTSVIFDPERNGTIYASATAPQGMYVTHDGGVSWEPVAGQPSSWLNRTTGAFPDKKPASIAPQPMKVALTPNFLYVTYADYPGPWGVTFGEVWRQNRTSGAWDDITPRVGNSSPA--PYNNQTFPAGGFCGLSVDATNPNRLVVITLDRDP----------GPALDSIYLSTDAGATWKDVTQLSSPSNLEGNWGHPTNAARYKDGTPVPWLDFNNGPQWGGYGAPHGTPGLTKFGWWMSAVLIDPFNPEHLMYGTGATIWATDT---------------------LSRVEKDWAPS-WY--LQ-IDG-IE-EN-AIL--SLR-SPKSGAALLSGIGDISGMKHDDLTKPQKMFGAPQFSNLDSIDAA----------------------GNFPNVVVRAGSSGHEYDSACARG----------------------AYATDGGDAW-TIF--P---T---------CPPGMNASHYQGS-TIAVDASGSQIVWSTKLDEQASGPWYSHDYGKT------WSVPAGD--LKAQ-T---AN-VLS-DKVQDGTFYATDGGKFFVSTDGGKSYAAKGAGLVTGTSLMPAVNPWVAGDVWVPVPEGGLFHSTDFGASFTRVGTANATLVSVGAPKAPSAVFIWGTDKPGSDIGLYRSDDNGSTWTRVNDQEHNYSGPTMIEADPKVYGRVYLGTNGRGIVYADLTNEEKSTAKCANGQKGTHCY --------------MTDVTIK---------------TLAAERQ---------------------------T------------------------------------------------S----VERL--------------------------------------------------------------------------------------------------------------VQQF-------ADAGIRKSADDSVS---------------------------AQEK--QTLIDHL-----------------------NQKNSGPDKLTLQ--------------------------RKTRST---LNIPGTGGKS-KS---------------------VQI--EV-------------------------RKKRTFVKRDPQEAERLAAEEQAQRE----AEEQARREAEESAKREAQQKAE-REAAEQAKR-----------------------------------------EAAEQAKREAAEKDKVSNQQDDMT----------------------KNAQAEKARREQEAAELKRKAEEEARR-K-LEEEARRVAEEARRMAEENKWTDNA-EP-------TEDSSDYHV-TTSQHARQAEDESD----------REVEGGRGR----GRNAKAARPKKGNKHAESKA---------------------------------------DREEARA--------------------------------------------------------------------------------------------------------------------------------

SEFSQTAL---FPS-LPRTARGT--AVVLGNTPA-GDKIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVA--KTSPSGYYCASGDVHGNVRIWDTTQTTHILKTT-IPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARA-------------MNSVDF--KPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVA----LSNDKQFVAVGGQDSKVHVYKLSGASVSE-------VKTIVH--PAEI-TSVAFSNNGAFLVAT-----DQ--SR--KVIPYSVANNFELA-----HTNSWTFHTAKVAC------VSWSPDNVRLATGSLDNSVIVW--NMNKP--S--DHP--IIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNVPF----------- ----MTDVTIKTLAAER------QTSVERLVQQ-FA-----------------------------------DAGIRKSADDSVSAQE-KQTLIDHL-NQKNSGPDKLTLQRKTRSTL-----------------------------------------NIPGTGGKSKSVQIEVRKKRTFVKRDPQE-----------AER--LAA--EEQ-A-QRE---------------AEEQ----------------------------AR---------------RE-AE----------------E----SA---------------KRE-A---------------Q-Q-----------------------K-----------AEREAAE--------------QAK---------R-E------------------------AAEQAKRE-----------AA----------------EKDKVSNQQDDMT--------KNA---------QAEKARREQEAAELKRKAEEEAR------------RKLEEEARRVAEEAR------------RMAEENKWTDNAE-PTEDSSDYHVTTSQ------HA--------RQAEDESDREVEGGRGRGRNAKA--A-----RPKKGNK----HA---------------ESKADREEARA

CGVGFIAAIDGKPRRSVVEKGIEALKAVWHRGAVDADGKTGDGAGIHVAVPQKFFKDHVKVIGHRAPDNKLAVGQVFLPRISLDAQEACRCIVETEILAFGYYIYGWRQVPINVDIIGEKANATRPEIEQIIVGNNKGVSDEQFELDLYIIRRRIEKAVKGEQINDFYICSLSARSIIYKGMFLAEQLTTFYPDLLDERFESDFAIYHQRYSTNTFPTWPLAQPFRMLAHNGEI-NTVKGNVNWMKAHETRMEHPAFGTHMQDLKPVIGVGLSDSGSLDTVFEVMVRAGRTAPM-VKMMLVPQALTTTPDNHKALIQYCNSVMEPWDGPAAL-AMTDGRWVVGGMDRNGLRPMRYTITTDGLIIGGSETGMVKIDETQVIEKGRLGPGEMIAVDLQSGKLYRDRELKD-----------------HLA-----------T--LK-PWDKWVQNTTHLDELVKTASLKGEPSDMDKAELRRRQQAFGLTMEDMELILHPMVEDGKEAIGSMGDDSPIAVLSDKYRGLHHFFRQNFSQVTNPPIDSLRERRVMSLKTRLGNLGNILDEDETQTRLLQLESPVLTTAEFRAMRDYMGDTAAEIDATFPVDGGPEALRDALRRIRQETEDAVRGGATHVILTDEAMGPARAAIPAILATGAVHTHLIRSNLRTFTSLN-VRTAEGLDTHYFAVLIGVGATTVNAYLAQEAIAERHRRGLFGSMPLEKGMANYKKAIDDGLLK-IMSKMGISVISSYRGGGNFEAIGLSRALVAEHFPAMVSRISGIGLNGIQKKVLEQHATAYNEEVVALPVG----GFYRFRKSGDRHGWEGGVIHTLQQAVTNDSYTTFKKYSEQVNKRPPMQLRDLLELRSTKAPVPVDEVESITAIRKRFITPGMSMGALSPEAHGTLNVAMNRIGAKSDSGE-----GGEDPARFRPDKNGDNWNSAIKQVAS---------GRFGVT--AEYLN--QCRELEIKVAQGAKPGEGGQLPGFKVTEMIARLRHSTPGVMLISPPPHHDIYSIEDLAQLIYDLKQ-------------------INPDA--KVTVKLVSRSGIGTIAAGVAKANADIILISGNSGGTGASPQTSIKFAGLPWEMGLSEVHQVLTLNRLRHRVRLRTDGGLKTGRDIVIAAMLGAEEFGIGTASLIAMGCIMVRQCHSNTCPVGVCVQDDKLRQKFVGTPEKVVNLFTFLAEEVREILAGLGFRSLNEVIGRTDLLHQVDLDLNPRLAQVDPGGRNEVPDTLDARIVADARPLFEEGEKMQLAYNARNTQRAIGTRLSSMVTRKFGMFGLQPGHITIRLRGTAGQSLGAFAVQGIKLEVMGDANDYVGKGLSGGTIVVRPTTSSPLETNKNTIIGNTVLYGATAGKLFAAGQAGERFAVRNSGATVVVEGCGSNGCEYMTGGTAVILGRVGDNFAAGMTGGMAYVYDLDDSLPLYINDESVIFQRIEVGHYESQLKHLIEEHVTETQSRFAAEILNDWAREVTKFWQVVPKEMLNRLEVPVHL -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTD-----------------VTIKTLAAER-QTSVER-----------------------------L--VQ-QFA-DAGIRK-SADDSVSAQ------------E----------------KQT------LIDHL--N-QKNS----------GP------------------------DK-------LTLQRKTRSTLNIPGTGGKSKSVQIEVRKKRTFVKRDPQEAERLAAEEQA-QREAEE------------------------------------------------------------------------------------------------------------------QARREAEESA--------------------------------------------------------------------------------------------K-RE-------AQQKAE---------------------------------------------RE--AA---------------------------------------------------------------------EQAKREAAE----QAKREAAEK-DKVSNQQD-D------------------------------------------------------------MTK-NA--QAEKARREQEA--AELKRKAEE----------------------EARRKLEEEARRVAEEARRMAEENKWTDNAEPT-------EDSSDY--H----V------------------------------------TTSQHARQAEDESDREVEGGRGRGRNAKAARPKK---------------------GNKHA-E-------S---------------------------------K--------------------ADR--E---EARA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

SSISLKEII--PP--QPSTQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKF--SPIKG-SQYLCSGDESGKVIVWG-WTFDKESNSVEVNVK---SEFQVLAGP-----------ISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPRSTVGDDGSVVFY----QGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIEWSSSSHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSL-----SQNYVAVGLEEGNTIQVFKLSDLE-----VSFDLKT--PLRAKPSYISISPSETYIAAG-----DVG--KI-LLYDLQSRE----VKTSRWAFRTSKIN--------AISWKPAEEIEEDLVATGSLDTNIFIYSVKRPKIIKALNAHKDGVNNLLWETPSTLVSSGADACIKRWNVV---------------- ----MTDVTIKTLAAERQT----SVERLVQ------------------------------------------QFADAGIRKSADDSVSAQ----EKQTLIDHLN-----QKNSGPDKLTLQRKTRSTLNIPGTGGKSKSVQIEV--------R---------------------------------KKRTFVKR-------------DPQEAERLAAEEQAQR--E---AEEQ---------------A-----------------------------RR-------------EA----------------------------EES-----------AKREAQ------------------Q----------------KAE-------REAAE--------------QAK-----REA----AE-----------------------------QAKREAAEK-------------DKVSNQQDDM----------TKNAQ----AEKARREQEAAELKRKAEEEAR-------------RKLEEEARRVAEEAR-------RMAEENKWTDNAE-PTEDSSDYHVTTSQHARQAEDESDRE-------------VEGGRGRGR-------------N--AKAARPKK-----------GNKHAESKADREEARA

TPVTLANCEDEPIHVPGAIQPHGALVTLRADGMVLAASENIQALLGFVASPGSYLTQEQVGPEVLRMLEEGLTGNGPWSNSVETRIGEHLFDVIGHSYKEVFYLEFEIRTADTLSITSFTLNAQRIIAQVQLHN-------DTASLLSNVTDELRRMT-GY-DRVMAYRFRHDDSGEVVAESRRE----D-LESYLG-QRYPASDIPAQARRLYIQNPIRLIADVAYTPMRVFPALNPETNESFDLSYSVLRSVSPIHCEYL--------TNMGVRASMSISIVV-GGKLWGLFSCHH----------MSP--KL--IPY-PVRMSFQIFSQVCSAIVERLEQGRIAELLRVSTERRLALARRA-RDADDLFGALAHPDDGIAALIPCDGALVMLGGRTLSIRGDFE-----RQAGNVLQRLQRDPERD------IYHTD--N--W-----------------C-CGV-LAIRFHRQESGWIFWFRHEEVHRIRWGGKPEKLLTIGPSGPRLTPRGSFEAWEEVVRGHS---------------------------TPW--SETDL-AIAEKLRLDLMELCL --------------------------------------------------------------------------------------------------------------------------------------MTDVTIKTLAAERQTSVERLVQQFADAGIRKS------------ADDSVS-AQEKQTLIDHL-NQ---------------------------------------------------------------KNSGPDKLTL-QRKTRSTLNIPGTGGKSKSVQIEVRKKRTFVKRDPQEAERLAAEEQAQREAEEQARREAEESAKREAQQKAEREAAEQAKREAAEQAKREAAEKDKVSNQQ------------------DDMTKNAQA------EKARRE-QEA-AELKR------KAEEEARRKLEEEARRVAEEARRMAEENKWTDNAEPTEDSSDY--------HVTTSQH------------------------------------------ARQAEDESDREVEGGRGRGRNAKAARPK--KGN-KH-AESKADREEAR--A--

GLVPRGSHMMEILRGSPALSAFRINKLLARFQAANLQVHNIYAEYVHFADLNAPLNDSEQAQLTRLLQYGPALSSHTPAGKLLLVTPRPGTISPWSSKATDIAHNCGLQQVDRLERGVAYYIEASTLTAEQWRQVA------------------------------AELH-DRMM-----------ETV--FSSLTDAEKLFIHHQPAPVSSVDLL------------------------------------GEGR-QALIDANLRLGLALAEDEIDYLQEAFTKLGRNPNDIELYMFAQANSEHCRHKIF-NADWIIDGKPQPKSLFKMIKNTFETTPDYVLSAYKDNAAV--ME--G-----S---A-VGRY-----------FADHNTGRYDFHQEPAHILMKVETHNHPTAISPWPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNLRIPGFEQPWEEDFGKPERIVTALDIMTEGPLGGAAFNNEFGRPALTGYFRTYEEKVNSHNGEELRGYHKPIMLAGGIGNIRADHVQKGEIVVGAKLIVLGGPAMNIGFASVQRDNPEMERRCQEVIDRCWQLGDANPILFIHDVGAGGLSNAMPELVSDGGRGGKFELRDILSDEPGMSPLEIWCNESQERYVLAVAADQLPLFDELCKRERAPYAVIGDATEEQHLSLHDNHFDNQPIDLPLDVLLGKTPKMTRDVQTLKAKGDALNRADITIADAVKRVLHLPTVAEKTFLVTIGDRTVTGMVARDQMVGPWQVPVADCAVTTASLDSYYGEAMSIGERAPVALLDFAASARLAVGEALTNIAATQIGDIKRIKLSANWMAAAGHPGEDAGLYDAVKAVGEELCPQLGLTIPVGKDSMSMKTRWQEGNEQREMTSPLSLVISAFARVEDVRHTLTPQLSTEDNALLLIDLGKGHNALGATALAQVYRQLGDKPADVRDVAQLKGFYDAMQALVAARKLLAWHDRSDGGLLVTLAEMAFAGHCGVQVDIAALGDDHLAALFNEELGGVIQVRAEDRDAVEALLAQYGLADCVHYLGQALAGDRFVITANDQTVFSESRTTLRVWWAETTWQMQRLRDNPQCADQEHEAKANDTDPGLNVKLSFDINEDIAAPYIATGARPKVAVLREQGVNSHVEMAAAFHRAGFDAIDVHMSDLLGGRIGLGNFHALVACGGFSYGDVLGAGEGWAKSILFNHRVRDEFETFFHRPQTLALGV------------NGCQMMSNLRELIPGSELWPRFVRNHSDR-FEARFSLVEVTQSPSLLLQGMVGSQMPIAVSHGEGRVEVRDDAHLAALESKGLVALRYVDNFGKVTETYPANPNGSPNGITAVTTENGRVTIMMPHPERVFRTVANSWHPENWGEDSPWMRIFRNARKQLG---------------------- ----------------------------------------------------------------------------------------------------------------------------------------MTDVTIKTLAAERQTSVERLVQQFADAGIRK---SADDSVSAQEKQTLIDHLNQKNSGPDKLTL--QRKTRSTLNIP---GTGGKSKSVQIEVRKKRTFVKRDPQEAERLAAEEQAQR--EAE-EQARR-E-AEE---------------------------SAKREAQQKAE--RE--------------A---------------AEQAKREAAEQAKREAAEKDKVSNQQDDMTKNAQAEKARREQEAAELKRK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEEEAR-------------------------------------------------------------------------RK--LEEEARR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAE----------------------EAR--R----MAE--E-NKWTDNAEPT--------------------------------------EDSSDYHVTTSQH----------------------------ARQAEDE--------------------SDR--------------------------E-------------------------VEG------GRGRGRNAK--------------------------------AARPKKGNKHAESKADREEARA

IDALTKDQRALFKQQLEIIARYLKMDLRAGDKAFVASQESQKALQAQLDLWQAEHGDIYAAGIEPAFDPLKARVYDSSWNWARQDALSMYYDIIFGRLRVVDREIVSQCIQIMNRSNPLLLEFMQYHIDHCPTERGETYQLAKELGQQLIENCKEVLGKPPVYKDVS----IPT-GPQTTIDARGNIQYQEVP---RASARKFEHYVKQ---MAEGGPISQYKVETIPFLHLRKKDEFGNWEYSKKLTGIYLDGLEAAARSGLTFQGKHAL--------MTGAGAGSIGAEVLQGLLSGGAKVIVTTSRFSRQVTEYYQGIYARCGARGSQLVVVPFNQGSKQDVEALVNYIYDTKNGLGWDLDYVVPFAAIPENGREIDSIDSKSELAHRIMLTNLLRLLGAIKTQKKERGYETRPAQVILPLSPNHGT------FGNDGLYSESKLALETLFNRWYSESWGNYLTI-CGAVIGWTRGTGLMSANNLVAEGVEKLGVRTFSQQEMAFNLLGLMAPAIVNLCQSDPVFADLNGGLQ----------FIPDLKGLMTKLRKEIMETSAIRQAVIKETAIENKVVNGE-D--HEALYRRVITEPRANLKYPFPELPDWDKDIKPLNDQLRGMVNLDKVVVVTGLAEIGPWGNARTRWEMEAYGKFSLEGC-----------------------------------------VEMAWMMGLI-KNHNGPLKGKPYSGWVDAKTGEPVDDKDVKAKYEKYILEHSGIRLIEPELFGGYDPNRKQLLQEVVIEQDLEPFEASKEQAEEFKREHGDKVEIFEIPETGQYTVRLRKGATLLIPKALQFDRLVAGQIPTGWDARRYGVPEDIIQQVDPVTLYVLVSVAEALLSSGITDPYEFYKYVHLSEVGNCIGSGVGGTSALRGMYKDRYLDKPVQKDILQESFVNTMAAWVNMLLLSSTGPIKTPVGACATAVESLDVGYDTIMQGKARVCLVGGFDDFQEEGSYEFANMGATSNAKEEFARGREPGEMSRPTSTTRNGFMESQGCGVQVIMTAQLALEMGVPIYGIVAMTSTATDKIGRSVPAPGQGVLTTAREKSGNFPSPLLDIKYRRRQLELRRQQIKQWKESEYLYLQEEVAAIKSQRSEEDGPFDETAYLRERTEHIEREARRQEAEAQTSFGNEFWRRDSRIAPLRGALATWGLTIDDLGVASFHGTSTVANDKNESDVICQQLKHLGRTKGNAVLGIFQKYLTGHPKGAAGAWMLNGCLQVLNTGIVPGNRNADNVDKVMEQFDYIVYPSRSIKTDGIKAFSVTSFGFGQKGAQAIGVHPKYLFATLDKAQYEAYCVKVQARQKKA---------------------YRFFHNGLINNKLFVAKDKAPYEDRIQSKVFLNPQSRVTQESNGELKFPA----------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------MTDVTIKTLAAE---------RQ---TSVE------------RLVQ--------------QFADA------------------GI--RK---------------SADDSVSAQEKQ---TLIDH-LN----------------------QKNSGP---------DKLT-L------------------------------QRKTRSTLNIP----------------------------------------------------GTGGKSKSVQ--IE--VR-KK--RT-------------FVK-----------------------------------------R---DPQ-EA---ERLA-------AEEQAQREAEEQARREAEESAKREAQQKAEREAAEQAKREAAEQAKREAAEKDKVSNQ--------------------------------------------------------------------------QDDMTKNAQAEKARREQEAAELKRKAEEEARRKLEEEARRVA-EEA-RRMAEENK----------WT---------DNAE-PTE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSSDYHVTTSQHARQAEDESDRE-VEG-GR-----------------------------------------GRGRNAKAARPKKGNKHAESKADREEARA

(a)	Residue pairs that are structurally aligned by TM-align program are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade.(more about the colors used)
(b)	Ranking of proteins is based on TM-score of the structural alignment between Model1 and the PDB structures in our template library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the model.

Function Prediction

Predicted EC Numbers

Rank	TM-score	RMSD^a	IDEN^a	Cov.	EC-Score	PDB Hit	EC No.
1	0.4175	5.40	0.07	0.62	0.3851	3c2wH	2.7.13.3

2	0.3676	5.84	0.09	0.60	0.3831	1jqoA	4.1.1.31

3	0.3899	5.73	0.07	0.62	0.3689	1bgxT	2.7.7.7

4	0.3501	7.06	0.08	0.66	0.3677	1y2mB	4.3.1.24

5	0.3520	6.76	0.08	0.64	0.3638	2ac1A	3.2.1.26

(a)	Ranking is based on EC-score, which is a confidence score for the Enzyme Classification (EC) Number prediction.
(b)	RMSD^a is the RMSD between models and the PDB structure in the structurally aligned regions by TM-align.
(c)	IDEN^a is percentage sequence identity in the structurally aligned region.
(d)	Cov. represents the coverage of the alignment and is equal to the number of structurally aligned residues divided by length of model.
(e)	EC-Score is defined based on the C-score of the structure prediction and similarity of the model with known enzyme structures, as identified using both global and local structural alignment programs. The global similarity score uses TM-score, IDEN^a,RMSD^a and Cov. of the structural alignment by TM-align, while the local match compares the structural and chemical similarity of local spatial motifs in the model with known catalytic site of enzymes. A prediction with a EC-score >1.1 signifies a prediction with high confidence (upto 3 digit numbers of EC) and vice versa (For details, see Ambrish, Kucukural and Zhang,Large scale benchmarking of protein function prediction using predicted protein structures, 2009, submitted).

Predicted GO terms

Rank	TMscore	RMSD^a	IDEN^a	Cov.	PDB Hit	Fh-Score	Associated GO Terms
1	0.7457	4.09	0.07	0.92	1ykdB	0.32	GO:0004016 GO:0004871 GO:0009975 GO:0006139 GO:0007154 GO:0007165 GO:0009058 GO:0009889 GO:0043283 GO:0044249 GO:0044260 GO:0060255 GO:0065007
2	0.4013	6.04	0.08	0.67	1t3tA	0.23	GO:0004642 GO:0005524 GO:0030554 GO:0006189 GO:0006541 GO:0009123 GO:0009124 GO:0009126 GO:0009127 GO:0009150 GO:0009152 GO:0009308 GO:0009987 GO:0019752 GO:0046040 GO:0005622 GO:0005623 GO:0005737
3	0.3488	6.91	0.08	0.65	1y2mD	0.22	GO:0016211 GO:0016841 GO:0006559 GO:0006575 GO:0006725 GO:0009056 GO:0009058 GO:0009063 GO:0009074 GO:0009308 GO:0009310 GO:0009698 GO:0009987 GO:0019439 GO:0019752 GO:0005622 GO:0005623 GO:0005737
4	0.3067	6.46	0.10	0.54	2pg7D	0.22	GO:0004497 GO:0005506 GO:0009055 GO:0016712 GO:0020037 GO:0043169 GO:0055114 GO:0005622 GO:0005623 GO:0005737 GO:0005783 GO:0005789 GO:0005792 GO:0012505 GO:0016020 GO:0042175 GO:0043229 GO:0044432 GO:0044444
5	0.2806	6.30	0.11	0.48	3ciiD	0.21	GO:0032393 GO:0002474 GO:0006955 GO:0006968 GO:0005623 GO:0005886 GO:0016021 GO:0042612 GO:0044459
6	0.2916	6.33	0.10	0.50	2z1kD	0.21	GO:0003824 GO:0043169 GO:0005975
7	0.3677	6.42	0.07	0.64	2cg3A	0.21	GO:0016787
8	0.3896	4.08	0.10	0.47	1ykdB	0.21	GO:0004016 GO:0004871 GO:0009975 GO:0006139 GO:0007154 GO:0007165 GO:0009058 GO:0009889 GO:0043283 GO:0044249 GO:0044260 GO:0060255 GO:0065007
9	0.4731	5.50	0.06	0.72	2veaA	0.21	GO:0000155 GO:0004672 GO:0004673 GO:0005524 GO:0008020 GO:0009883 GO:0016301 GO:0030554 GO:0042802 GO:0003008 GO:0006139 GO:0006793 GO:0007154 GO:0007165 GO:0009058 GO:0009314 GO:0009582 GO:0009605 GO:0009889 GO:0043283 GO:0044249 GO:0044260 GO:0050906 GO:0060255 GO:0065007 GO:0005623 GO:0016020
10	0.3389	5.95	0.09	0.54	2b8nB	0.21	GO:0016301

Consensus Prediction of Gene Ontology terms

Molecular Function    Biological Process Cellular Location

GO term GO-Score    GO term GO-Score GO term GO-Score

GO:0003824 0.204    GO:0008152 0.182    GO:0005623 0.209

GO:0004871 0.096    GO:0009987 0.160    GO:0044464 0.209

GO:0060089 0.096    GO:0044260 0.148    GO:0005737 0.127

GO:0005488 0.087    GO:0044238 0.140    GO:0044424 0.127

GO:0016829 0.075    GO:0044237 0.139    GO:0005622 0.127

GO:0009975 0.053    GO:0006139 0.097    GO:0016020 0.104

GO:0004016 0.053    GO:0009058 0.096    GO:0044425 0.043

GO:0016849 0.053    GO:0007165 0.095    GO:0005886 0.042

GO:0016874 0.045    GO:0007154 0.095    GO:0044444 0.042

GO:0016879 0.045    GO:0050789 0.095    GO:0032991 0.041

(a) Ranking in the first table is based on a function prediction score (Fh-score), which is calculated based on the C-score of the structure prediction and the TM-score, IDEN^a, RMSD^a and Cov. of the structural alignment by TM-align between the predicted model and the PDB structures (For details, see Ambrish, Kucukural and Zhang,Large scale benchmarking of protein function prediction using predicted protein structures, 2009, submitted).

(b) RMSD^a is the RMSD between models and the PDB structure in the structurally aligned regions by TM-align.

(c) IDEN^a is the percentage sequence identity in the structurally aligned region.

(d) Cov. represents the coverage of the alignment and is equal to the number of structurally aligned residues divided by length of model.

(e) A consensus prediction of GO terms is derived from the structural analogs that have an Fh-score of >=1.0. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on the Fh-score of the template from which the GO term is derived. A prediction with a GO-score >0.5 signifies a prediction with high confidence and vice versa.

Predicted Binding Site

Binding site residues in the model:

ALA:	144	ALA:	145	ALA:	148	GLN:	162	MET:	165	LYS:	167	GLU:	188
ARG:	192	SER:	226	ASP:	227	TYR:	228	HIS:	229	VAL:	230	THR:	231
THR:	232	LYS:	272	ALA:	273	ASP:	274	ARG:	275	GLU:	276	GLU:	277
ALA:	278	ARG:	279	ALA:	280

Identified analogs with similar binding site:

Rank PDB
Hit TM-score RMSD^a IDEN^a Cov. BS-score Download
Complex Binding site residues on the predicted model

1 2zq0B 0.3682 5.59 0.06 0.54 0.27 Download 144,145,148,162,165,167,188,192,226,227,228,229,230,231,232,272,273,274,275,276,277,278,279,280

2 2b9wA 0.2748 6.23 0.07 0.46 0.19 Download 160,161,162,164,170,174,175,176,237

3 1kbiA 0.3361 6.21 0.05 0.56 0.18 Download 13,79,80,81,126,129,130

4 2iagA 0.3039 5.45 0.07 0.45 0.17 Download 130,134,137,263,264,267,268,270,271

5 1lg9A 0.2747 6.32 0.09 0.45 0.16 Download 8,9,12,13,130,133,134,137,264,267

6 1bg0_ 0.2700 6.66 0.10 0.48 0.15 Download 217,218,219,220,221,233,234,235,253,259,260

7 1gt8A 0.2914 6.61 0.07 0.51 0.15 Download 133,137,138,139,140,141,142,143,144,145,223,225,263,266,267,270,271,274

8 1n6bA 0.3018 6.53 0.05 0.53 0.15 Download 9,12,130,133,134,137,264,267,270

9 1z8nA 0.3086 6.46 0.05 0.53 0.15 Download 203,207,218,219,220,221,222,236,253,259,260,261,262,263,265,266,267

10 1kbiA 0.3361 6.21 0.05 0.56 0.15 Download 137,141,263,265,266,267,268,269,270,271

(a) Ranking of the analogs in the table is based on their BS-score. BS-score is calculated by first finding the structural analogs of the predicted model based on their TM-score, IDEN^a and Cov. of the structural alignment. The ligand(s) in the analog structure are then transferred onto the model and the fitness of the ligand-model complex (BS-score) is calculated by comparing the local structure and sequence similarity in the binding site region. (For detail, see Kucukural, Szilagyi, Ambrish, and Zhang, Template based ligand binding site prediction on modeled protein structure, 2009, in preparation).

(b) A BS-score of >0.5 signifies a binding site prediction with high confidence and vice-versa.
(c) RMSD^a the RMSD between residues that are structurally aligned by TM-align.

(d) IDEN^a is the percentage sequence identity in the structurally aligned region.

(e) Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the model.

(f) The image shows the ligand-protein complex with the best BS-score. The ligand is depicted in magenta colored ball & stick, the predicted binding site residues interacting with the ligand are shown as transparent green spheres, while the N & C terminus in the model are marked by blue and red spheres respectively.

	Please cite following articles when you use the I-TASSER server:
1.	Yang Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9:40 (2008).
2.	Yang Zhang. Template-based modeling and free modeling by I-TASSER in CASP7. Proteins, 8: 108-117 (2007).
3.	Sitao Wu, Jeffrey Skolnick, Yang Zhang. Ab initio modeling of small proteins by iterative TASSER simulations. BMC Biology, 5:17 (2007).