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I-TASSER results for job id S34349

  Submitted Sequence

>your_protein
MRNLPCLGTAGGSGLGGIAGKPSPTMEAVEASTASHRHSTSSYFATTYYHLTDDECHSGV
NQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRP
RAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLR
NLAAQKEQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPL
NSSESGGASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSH
PQLVHGNHQALQQHQQQSWPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSL
SPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDD
QARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSN
RRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVS
TINGLSSPSTLSTNVNAPTLGAGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPC
PLGVGGHQNTHHIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAV
TPIPSFNHSAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAPAHHHIVPGDGGRPAG
VGLGSGQSANLGASCSGSGYEVLSAYALPPPPMASSSAADSSFSAASSASANVTPHHTIA
QESCPSPCSSASHFGVAHSSGFSSDPISPAVSSYAHMSYNYASSANTMTPSSASGTSAHV
APGKQQFFASCFYSPWV

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                  
MRNLPCLGTAGGSGLGGIAGKPSPTMEAVEASTASHRHSTSSYFATTYYHLTDDECHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNSSESGGASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVTPIPSFNHSAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAPAHHHIVPGDGGRPAGVGLGSGQSANLGASCSGSGYEVLSAYALPPPPMASSSAADSSFSAASSASANVTPHHTIAQESCPSPCSSASHFGVAHSSGFSSDPISPAVSSYAHMSYNYASSANTMTPSSASGTSAHVAPGKQQFFASCFYSPWV
PredictionCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCHCCCCSSSSSSSCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHSSCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCC
Conf.Score97766210367776556789989624654166877677666876666655556788756104772656894080899999999986488740256766015674354553202677767886468787647889999999986418640079999999870787777788568889999860257455778877666778876787677788787877788856466677887576766455666888888768775102330465455011345667842036000015123566677877657778700103676567666677767777776655657655666653457887766557875445677554455543344433346667543443456767778887776667866565667788889776257999999999998651599899999999872998567220000111354420333344678888888888888877778888988888887667887888887788888887666777888777888888778888777787777777677677877777877777767777787737776666776678877777867777767566677788885677888898767665578888899886667768876557555248989888501488888888887776677889876546898522543056778998788763345667665543655667431245278987655477523678654676678863000167770101466689888766688786243454654036779

  Top 5 Models predicted by I-TASSER

Download Model 1 Download Model 2 Download Model 3 Download Model 4 Download Model 5
C-score=-1.11
 C-score=-1.65
 C-score=-2.53
 C-score=-3.40
 C-score=-3.60
 
Estimated accuracy of Model1: 0.58±0.14 (TM-score)    11.2±4.6Å (RMSD)    (Read more about C-score of generated models)

  Top 10 templates used by I-TASSER

RankPDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840
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Sec.Str
Seq		CCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCHCCCCSSSSSSSCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHSSCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCC
MRNLPCLGTAGGSGLGGIAGKPSPTMEAVEASTASHRHSTSSYFATTYYHLTDDECHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNSSESGGASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVTPIPSFNHSAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAPAHHHIVPGDGGRPAGVGLGSGQSANLGASCSGSGYEVLSAYALPPPPMASSSAADSSFSAASSASANVTPHHTIAQESCPSPCSSASHFGVAHSSGFSSDPISPAVSSYAHMSYNYASSANTMTPSSASGTSAHVAPGKQQFFASCFYSPWV
11zlgA 0.10 0.15 0.79 1.28Download ---------AAGPGAAAARRLDESL----AGSVQR-ARCASRCLSLQITRISAFFQHFQNNGSLV-------WCQNHKQ------------C--S---KCLEPC---------KESGDLRKHQC---QSFCEP-----------LFPK-----------KSYEC-LTSCEFLKY-------ILLVKQGDCPAPEKASGFAAACVESCEVDNECSGVKKCCSNGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQ--------LEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTTDERVQLTDIR------PSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWM--------VSSKSLVPTKKKRRKTTDGFQNSVI---LEKLQP----CDY------------------VVELQAITYW-----QTRLKSAKVSLHFTSTHATNNKEQLVKTRKGGIQTQLPFQRRRPTRPLEVGAPFYQDGQLQVKVYWKKTEDPTVNRYHVRWFPEACAHNRT--TGSEASSGMTHENYIILQDLSFSCKYKVTVQPIRPKSHSKAEAVFFTTPPCSALKGK------SHKPIGCLGEAGHVLSKVLAKPENLSASFIVQDVNITGHFSWKMAKA------NLYQPMTGFQVTWAEVTTESRQNSLPNSIISQSQILPSDHYV---------LTVPNLRPSTLYRLEVQVLTPGGEGPATIKTFRTPELPPSSAHRSHLKHRHPH-----HYKPSPERYGKPIPNPLLGLDST--RTGHHHHHH------------------
22gsxA 0.06 0.19 0.92 3.11Download IPPILNGRISYYSTPIAVGTKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTTNFSMNGNKSVW----CQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSV----------------------------TYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPVKEPPILRVGVDEGYRLQGPWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGY----------------------------------------KLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVEQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEATHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECED
32k27A 0.60 0.11 0.19 4.97Download -----------------------------------------------MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSGAPGGGSHHHHH---------------------------------------------------------------------------------------H------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41c51A 0.09 0.07 0.70 2.02Download ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-------GGGGGGGGGGGGGGGGG-------------------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-GGGGGGGGGGGGGGGGGGGGG--------------
51ti2A 0.09 0.17 0.90 1.19Download VVRLTNSSTGGPVFVYVKDGK-------IIRMTPMD-FDDAVDAPSWKIEARGKTFTP-PRK-------TS-IA-PYTAGFKSMIYSDLR---------IPYPMKRKSFDPNGERNPQLRGGLSKQDPWSATDIVVAEINRIKHAGNVGYRHSTYFRFMNGFTYADHNPDSWEGWHWGGMHMWGFSWRLGNPEQYDLL---EDGLKHAEM-WSSDPETNSGIYAGFESNIRRQWLKDLGVDPHMNHTARLVADKWFSPKAYTWLKEDSYDKEYVAANAHGFEEWADYVLGKTDGTPKTKNTYLAAGGLGGWGGACRASHQGMGKPGSNMWSTTQGVPLDYEFYFPGYAEGGISGDCENSAAGFKFAWRMFDGKTTFPSPSNLNTSAGQHIPRLKIPECIMGGKFQWSGKGFAGGDISHQLHQYEYPAPGYSKIKMFWKYGG------PHLGTM-TATNRYAKMYTHDSLE---FVVSWFEGEVPF-----ADIILPACTNFERWDISEFANCSGYIPDNYQLCNHRVISLQAKCIEPVGESMSDYEIYRLFAKKLNIEEMFSEGKDELAWC----EQYFNATDMPKYMTWDEFFKKGYFVVPDNPNRKKTVALRWFAEGREKDTPDWGPRLNNQVCRKGLQTTTGKVEFIATSLKNFEEQGYIDEHRPSMHTYVPAWESQKHSP---LAVKYPLGMLSPHPRFSMHTMG-----DGKNSYMNYIKDHRVEV----DGYKYWIMR---VNSIDAEARGIKNGDLIRAYNDRGSVILAAQVTECLQP---------GTVH-SYESCAVYDPLGTAG--KSADRGGCINILTPDRYISKYACGMANN-----TALWDYEI
62k27A 0.60 0.11 0.19 4.43Download -----------------------------------------------MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSGAPGGGSHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76paxA 0.91 0.14 0.16 8.23Download -------------------------------------------------------SHSGVNQLGGVFVNGRPLPDSTRQRIVELAHSGARPCDISRILQVSNGCVSKILGRYYATGSIRPRAIGGSKPRVATPEVVSKIAQYKQECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82q7zA 0.09 0.22 0.96 2.86Download QCNAPEWLPFAPTNLTDEFEFPIGTYLNYECRPGYSGRTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGS--------QIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIST---------NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQESPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKADPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGT--SLKYECRPEYYGR----------------PFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGADEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGS
92k27A 0.62 0.11 0.18 4.96Download -------------------------------------------------HNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSGAPGGGSHH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101e07A 0.13 0.14 0.74 1.19Download -------------------------------------------------------------------------------KLIE-----STP------FNVAEG----------KEVLLLVHNLPQHLFGYSW---------YKGERVD----------------GNRQI-------------IGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAV-ALTCEPEIQNTT-------------------YLWWVN----------NQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNELSVDHSDPVILNV-------------------------LYGPDDPTISPSYTYYRPGVNLSLSCHAASNP-PAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANN--SASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYL---VNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHS----ASNPSPQYSWRINGIPQQHT-QVLFIA---KITPNNNGTYACFVNLATGRNNSIVKSITVSA--------------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: MUSTER   2: PROSPECT2   3: HHSEARCH   4: PPA-I   5: MUSTER   6: HHSEARCH I   7: FUGUE   8: PROSPECT2   9: HHSEARCH II   10: MUSTER   

  10 proteins in PDB which are structurally closest to the first I-TASSER model (identified by TM-align)

RankTM-scoreRMSDaIDENaCov.PDB
Hit
10.9003 1.47 0.06 0.922gsxA
Model1
 
20.2495 8.47 0.02 0.392q7zA
Model1
 
30.2212 8.53 0.02 0.352qzvA
Model1
 
40.2031 8.22 0.04 0.312pffB
Model1
 
50.1993 8.32 0.03 0.301xi4A
Model1
 
60.1929 7.55 0.07 0.281sjjA
Model1
 
70.1835 7.87 0.02 0.281l3wA
Model1
 
80.1789 8.13 0.02 0.271e07A
Model1
 
90.1745 8.03 0.03 0.263b43A
Model1
 
100.1704 8.52 0.03 0.272hyeC
Model1
 
Structural alignment using TM-align
 
ISCGSP-PPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKS-VW--CQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSV----------------------------TYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGY----------------------------------------KLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSR 
------MRNLPCLGTAGGSGLGGIAG--------------------KP--SPTMEAVEASTASHRHSTSSYFATTYYHLTDDECHSGVNQLGGVFVGGR---PLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQQSTGSGSSSTSAGN---SISAKVSV--SIGGNVSN----VASGS--R-----------GTLSSSTDLMQTATPLNSSESGGASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSWYPT---------------------SLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCP--------------------LGVGGHQNTHHIQSNGHAQGHALVPAISPRLNFNSGSFGAM------YSNMHHTALSMSDSYGAVTPIPSFNHSAVGPLAPPSPIPQQGDLTPSSLY----------------------PC-HM-TLRPPPMAPAHHHIVPGDGGRPAGVGLGSGQSANLGASCSGSGYEVLSAYALPPPPMA-S---------SSAADSSFSAASSASANVTPHHTIAQESCPSPCSSASHFGVAHSSGFSSDPISPAV-S---SYAHMSYNYASSANTMTPSSASGTSAHVAPGKQQFFASCFYSPWV---------------------------- 
 
QCNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTIT----------------------------------------------NGDFISTNRENFHYGSVVTYRCNPGSG-------GRKVFELVGEPSIYCTSNDDQVGIWSGPA----------------------PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMK------------GPRRVKCQA-----LNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMG---------------------------------------------------------------------QLLNGRVLFPVNLQLGAKVDFVCDEGFQL------KGSS-ASYCVLAGMESLWNSSVPVCEQIFCPSPPV-------IPNGRHTGKPL----EVFPFGKAVNYTCDPHPDRGTSFD-----------LI-GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVG--SRINYSCTTGHRLIGHSSAE--CILSGN----AAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPN----------------KCTPPNVENGILVSDNRSLFSLNEVV------EFRCQP---G-F--V------------------------MKGPRRVKCQ---ALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFSLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCTSRAHDA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 
------------------------------------------------------------------------------------------------------------------------------------MRNLPCLGTAGGSGLGGIAGKPSPTMEAVEASTASHRHSTSSYFATTYY---------------HLTDDECHSGVNQLGGVFVGGRPL---------------------PDSTRQKIVELAHSGARPCDISRILQVSNGCVSKIL------------------------------GRYYETGSIRPRA--------IGGSKP--------------------------------------------------------------------------------RVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQQSTGSGSSSTSAGNSI----------------------SAKVSVSIG-GNVSNV------ASGSRGTLSSSTDLMQTATPLNSSESGGASN------SGEGSEQ----EAIYEK-----------LRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSH-----P-------------QLV----------HG-N--------H---------------------QALQQHQQ---QSWPPRHYS--GSW-------------------YPTS----LSEIPISS-APNIA--SV-TAYASGPSLAHSLSPPNDIESLASIGHQRNCP------V-ATEDIHLKKELDG--HQSDETGSGEGENSN-GGASNIGNTEDDQARLILKRKLQRN-----------------RTSFTNDQID--SLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNST-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVTPIPSFNHSAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAPAHHHIVPGDGGRPAGVGLGSGQSANLGASCSGSGYEVLSAYALPPPPMASSSAADSSFSAASSASANVTPHHTIAQESCPSPCSSASHFGVAHSSGFSSDPISPAVSSYAHMSYNYASSANTMTPSSASGTSAHVAPGKQQFFASCFYSPWV 
 
GCGCPCGCGAMATEEAIIRIPPYHYIHVLDQNSNVSRVEVGP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTYIRQDNERVLFAPVRMVTVPPRHYCIVANPVSRDTQSSVLFDITGQVRLRHADQEIRLAQDPFPLYPQVVLPNTALHLKAL-----------------LDFEDKNGDKVMAGDEWLFEGPGTYIPQKEVEVVEIIQATVIKQNQALRLRARKECFDREGK--------GRVTGEEWLVRSVGAYL-------P-------AVFEEVLDLVDAVILTEKTALHLRALQNFRDLRGVLHRTGEEWLVTVQDTEA---HVPDVYEEVLGVVPITTL-KSFFLQPGER-LER----G----IQ-DV--YVLSEQQGLLLKALQPLEEGESEEKV-------------------SHQAGDCWLIRGPLEYVPSAKVEVVEERQAI---PLDQNEGIY----VQDVKTGKVRAVIGSTYMLTQDEVLWE-----------------------KELPSGVEELLNLGHDPLADRGQKGTAKPLQPSAPRNKTRVVSYRVPHNAAVQVYDY-------------RAKRARVVFGPELVTLDPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFELKNRNDPAEAAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRMAVFGFEMSEDTGPDGTLLPK-----ARDQAVFPQNGLVVSSVDVQSV-E---------PVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQR---------------------LEQEARGRLERQKILDQSEAEK---------ARKELLELEAMSMAVESTGNAKAEAESRAE-----------------------------------------------AARIEGE--GSVLQAKLK--A-QALAIE------------TEAELERVKK-------------VREMELIYARAQLEL----------- 
------------------------------------------MRNLPCLGTAGGSGLGGIAGKPSPTMEAVEASTASHRHSTSSYFATTYYHLTDDECHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNSSESGGASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQ--ALQ----------QH----------------------------QQQSWPPRHY-----------------------SGSWYPTSLSEIPISSAPNI--------ASVTAYASG--------------------------PSLAHSLSPP------NDIESLASIGHQRNCPVA-------TEDIHLKKELDGHQSDETGSGEGEN-----------------SNG-----GA----SNIGNT-----EDDQARLI-LK--RKLQRNRTSFTNDQIDSL-EKEFERTHYPDVFARERLAGKIGLPEARIQVWFS------------NRRAKWRREEKLRNQRRTPNSTGASATSSSTS------------------ATASLTDS----PNSLSACSS--LLSGSAGGPSVST-INGLSSPSTLSTNVNAPTLGAGIDSSESPTPIPHIRP-------------------------------------------------SCTSDNDNGRQSEDCRRV------------CSP--CPLGVG----------GH--Q----NTHHIQS------------------------------------------------------NG--H--AQGH--A-----LVPAISPRL------------NFNSGSFGA------------MYSNMHHTALSMSDSYGAVTPIPSFNH--SA-VG--PL--A---PPSPIP--QQGDLTPSSLYPCHMTLRPPPMAPAHHH----IV-PGDGGRPAGVGLGSGQSANLGAS------------------------CSGSGYEVLSAYALPPPPMASSSAADSSFSAASSASANVTPHHTIAQESCPSPCSSASHFGVA--HSSGFSSDPISPAVSSYAHMSYNYASSANTMTPSSASGTSAHVAPGKQQ-----------FFASCFYSPWV 
 
MDAYSTRPLTLSHGSLEHVLLVPTASFFIASQLQEQFNKILPEPTEGFAADDEPTTPAELVGKFLGYVSSLVEPSKVGQFDQVLNLCLTEFENCYLEGNDIHALAAKLLQENDTTLVKTKELIKNYITARIMAKRPFDKKSNSALFRAVGEGNAQLVAIFGGQGNTDDYFEELRDLYQTYHVLVGDLIKFSAETLS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELIRTTLDAEKVFTQGLNILEWLENPSNTPDKDYLLSIPISCPLIGVIQLAHYVVTAKLLGFTPGELRSYLKGATGHSQGLVTAVAIAETDSWESFFVSVRKAITVLFFIG-------------VRCYEAYPNTSLPPSILEDSLENNEGVPSP----MLSISNLTQEQVQDYV--NKTNSHLPAGKQVEISLVNGAKNLVVSGPPQSLYGLNLTLRKAKAPSGLDQSRIPFSERKLKFSNRFLPVASPFHSHLLVPASDLINKDLVKNNVSFNAKDIQIPVYDTFDGSDLRVLSGSISERIVDCIIRLPVKWETTTQFKATHILDFGPGGASGLGVLTHRNKDGTGVRVIVAGTLDINPDDDYGFKQGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG---------------------GG-GGGGGGGGGGGGG-GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG---------GGGGGGGGGGGGG-GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG----------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG--GG-GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGQGSQEQGMGMDLYKTSKAAQDVWNRADNHFKDTYGFSILDIVINNPVNLTIHFGGEKGKR--------IRENYSAMIFETIVDGKLKTEKIFK--EINEHSTSYTFRSEKGLLSATQFTQPALTLMEKAAFEDLKSKGLIPADATFAGHSLGEYAALASLADVMSIESLVEVVFYRGMTMQVAVPRDELGRSNYGMIAINPGRVAASFSQEALQYVVERVGKRTGWLVEIVNYNVENQQYVAAGDLRALDTVTNVLNFIKLQKIDIIELQKSLSLEEVEGHLFGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ 
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRNLPCLGTAGGSGLGGIAGKPSPTMEAVEASTASHRHSTSSYFATTYYHLTDDECHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNSSESGGASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSW-----------------------------------------------------------------------------------------------------YPTSLSEIPISSAPNI-AS------------------------VTAYASGPSLAHSLSPPN--DIE-------S--LASIGHQ--RNC--------------------------------P----VATEDIHL----KKELD-GH--------------------------------------------------QSDET----------------------GS-GE-GENSN-----------------------------------GG----A--------------S------NIGNTED----------------DQARLILKRKLQRNRTSFTNDQ-IDSLEKEFERTHYPDVFARERLAGKIGLPEA-------------------------RIQV---------------------WFSN-----------------------RRAK-W----------------R-REEKLRNQR-RTPN------------------------------S----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-------------------------------------------------GA----SATS---------------------------------------------------------SSTSATASLTDSPN--------SLSACS-SL--------------------------------------------------------------------------------------LSG--SAGG-P----------------SVSTINGLSSPSTLS------------------------TNVNAPTLGAGIDSSE--S---PTPIPHIRPSCTSD---------------------NDN-GRQSEDCRR-----------------------VCS-------------------------------PCPLGVG----------------------------------------------------------------------------------------------------GH--------------------------------------------------QNT-HH--IQ--SN--GHA---------------QG--------HALVPAISPRLNFNSGSFGA-------------MYSNMHHTALSMSDSY-------G------------------------------------------------------------A-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTPIPSFNHSAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAPAHHHIVPGDGGRPAGVGLGSGQSANLGASCSGSGYEVLSAYALPPPPMASSSAADSSFSAASSASANVTPHHTIAQESCPSPCSSASHFGVAHSSGFSSDPISPAVSSYAHMSYNYASSANTMTPSSASGTSAHVAPGKQQFFASCFYSPWV 
 
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GCQIINYRTDAK--QKWLLLT-GISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFL--------ITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEKWLK------------------EDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLA------DITQIVDVFMEYNLIQQCTAFLLDALKNNR---------------PSEGP-LQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQ-------LCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIE-LFESFK----SF-EGLF---------------------------YFLGSIVNFSQDPDVHF-KYIQ-AACKTGQIKEVERICRES-----NCYDPERVKNFLKEAKLTDQLPLIIVC------------DRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAK------TNRLAELEEFINGPNNAHIQQVGDRCY-DEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANS-TRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDKLDASESLRKEEEQATETQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 
-----------------------------------------------------------------------------------------------------------------------------------------------------MRNLPCLGTAGGSGLGGIAGKPSPTMEAVEASTASHRHSTSSYFATTYYHLTDDECHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNS--SESGGASNSGEGSEQ-----EAI------------Y-E---------------------K----------LRLL---N-----TQHAAGPGPLE-----PARAA-------------PLVGQSPNHLGTRSSHPQLV--------------------H---GN-----------------------------------------HQ-------------------------------ALQ-----------------------------------QHQQQSW---------------------PPRHYSGSWYPTSLSEIPISSAPNI--A---SV---T--------------------AYA-----------------SGPSLAHSLSPPND------------------IESLASI--GH-QRNCPVATE---------------DIHLKKELDGHQSDETG---SG--EG--EN--SNGGA--------------------SNIGNTEDDQARLIL-KRK-----------L--QRNR-----------------T-SFTNDQIDS-L----------E---KEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSA-TASLT-DSPN-SLSACSSL--LS-GSAGGPSVSTINGLSSPSTLSTN---------------VNAPTLGAGIDSSE-------------------------SPTP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPHI-RP--SCTSDNDNGRQSEDCRRVC-S-----------P--C--PL------------------------------------------GVGGHQNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVTPIPSFNHSAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAPAHHHIVPGDGGRPAGVGLGSGQSANLGASCSGSGYEVLSAYALPPPPMASSSAADSSFSAASSASANVTPHHTIAQESCPSPCSSASHFGVAHSSGFSSDPISPAVSSYAHMSYNYASSANTMTPSSASGTSAHVAPGKQQFFASCFYSPWV 
 
------------------------------------------------------------------------------------------------------------------------------------------RL--D-----HLAEKFRQKASIHESWTDGKEAMLQQKDYETATLSEIKALLKKHEAFESDLA----AHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNL----------GALTQKRREA-LER-----TEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERQAILGIHNE-----------------------------------------VSKIVQTYHVNMAGTNPYTTITPQEING--KWEHVRQLVPRRDQALMEE------H-ARQQQNERLRKQFGAQ----------------ANVIGPWIQTKMEEIGRISIEMHG------------------TLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQQIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDCEDFRACLISMGYNMGEAEFARIMSIVDPNRMGVVTFQAF-IDFM--SRET-ADTDTAD--QVMASFKILAGDKNYITVD--ELRRELPPDQAEYCIAR-------------------------MAPYNGRDA-----V--P---GALD-----------------------------YMSFSTALYGESDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 
MRNLPCLGTAGGSGLGGIAGKPSPTMEAVEASTASHRHSTSSYFATTYYHLTDDECHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLL-----------------------------------------QENVCTNDNIP-SV--SSINRVLRNLAAQKEQ--QS--T-GSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSS-ST--DL-M---QTAT-PLNSSES-----------------------------------------------GGASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVG-QS--------PNHLGTRSS--H---PQL--VH--G--NH--QALQQHQQQSWPPRHYSGSW---------YPTSLSEIPISSAPNIA--SV-TAY-ASG-PSLAH-----SLSPPNDIESLASIGHQRNCPVA-TED-IHLK-KE--L--D--GH------------------------Q-SDE-TG-SG--EG--E--NS--NGGASNIGNTEDDQA-----------R---------------------------------------LI--LK---RKL---QRNRTSFTNDQIDSLEKEFERTHYPDV--FARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTLG--------AGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVTPIPSFNHSAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAPAHHHIVPGDGGRPAGVGLGSGQSANLGASCSGSGYEVLSAYALPPPPMASSSAADSSFSAASSASANVTPHHTIAQESCPSPCSSASHFGVAHSSGFSSDPISPAVSSYAHMSYNYASSANTMTPSSASGTSAHVAPGKQQFFASCFYSPWV 
 
DWVIPPIKVSENERGPFPKRLVQIK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNKDR---------------------FNKV-YYSITGQGA--------DNPPQGVFRIEWETGWMLVTRPLDREEYDKYV-----------------LSSHAVSENGSPVEEPMEI-TINVI-DQNDNRPKFTQDVFRGSVREGVQPGTQV----MAVSATDEDDNIDSL-NGVLSYSILKQDPEEPIPNLFTINRETGVISLIGTGLDREKFPEYTLTVQATDLEGAGLSVEGKAIIQITD-------------------ANDNAPIFDPKTYTALVPENEIGFEVQRLS------VTDLDM--PGTPAWQAVYKIRVNEGGFFNITTDPESNQGILTTAK-GLDF--ELRKQYVLQITVENAEPFSVPLPTSTATVTVTVEDVN--E--APF--FVPAVSRVDVSEDLSRGEKIISLVAQDPDKQ-QIQKLS-Y-------------------------------FIGND-P-----ARWLTVN--KD-NGIVTGNGNLDR-------ESEYVKNNTYT------VIMLVTDDGVSVGTGTGTLILHVLDVNDNGPVPSPRVFTMCDQNPEPQVLTISDADIPPNT----------------------YPYKVSLSHGSDLTWKAELDSKGTSMLLSPTQQLKKGDYSIYVLLSDAQNNPQLTVVNATVCSCEGKAIKCQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 
-------------------------MRNLPCLGTAGGSGLGGIAGKPSPTMEAVEASTASHRHSTSSYFATTYYHLTDDECHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNSSESGGASNSGE-GSEQE-----AIYEKLR--------LLNTQHAAGPGPLEPARAAPLVG-----Q-S-PNHLGTRSSHPQLVHGNHQALQ-QHQQQSW---------PPRHYSGSWYPT-------SLS-EIPISSAPNI-----------------------ASVTA------------------------------YASGPSLAHSLSPPNDIESLASIGHQR--NCPV----------------ATEDIHLKKELDGHQSDETGSGEG-----------E--------NSNGG--ASNIGNTEDDQARLI-L-------------------KRKLQRNRTSFTNDQIDSLEKEFERTH---------YPDVFARERL---AGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSP--NSL-SACSSLLSGSAG-GPSVSTINGL--------SSPSTLSTNVNAP------TLGAGIDSSESPTPIPHIR-----------------------------PSCTSDNDNGRQSEDCRRVCSPCPLGVGG--------HQNT-----------------------------------------------------HHIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVTPIPSFNHSAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAPAHHHIVPGDGGRPAGVGLGSGQSANLGASCSGSGYEVLSAYALPPPPMASSSAADSSFSAASSASANVTPHHTIAQESCPSPCSSASHFGVAHSSGFSSDPISPAVSSYAHMSYNYASSANTMTPSSASGTSAHVAPGKQQFFASCFYSPWV 
 
KLTIESTPFNV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIG---------YVI-GTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQL--SNGNRTLTLFNVTRNDTASYK-----CETQNPVSARRS-DSVI-LNVLYG-P---------D----APTISP--L--NT---S---Y-RSGENLNL---------------------------SCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTG-LNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWV--------------------------------------------------NNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNELSVD-----------------HSD--PVILNVLYGPDDPTISPSYTYYRPGVNLSLSC---HAASNPPAQYSWLIDGNIQQ----HTQELFISNITE-----------KNSGLYTCQANNSASGHSRTTVKT--ITVSAE--------------------LPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFN----VTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKI-------------TPNNNGTYACFVSNLATGRNNSIVKSIT------------------VSA--------------------------------------------------------------------------------------------------- 
-----------MRNLPCLGTAGGSGLGGIAGKPSPTMEAVEASTASHRHSTSSYFATTYYHLTDDECHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNSSESGGASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSWP------------------------------PRHYSGSWYP--TSLSEI------PIS--------SAPN-I---------------------------A-SVTAYASGP----S-------LAHSLS-----PPNDIE--------------SLASIGHQRNCPVA---------TEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFE------RTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRR-----------------------------------EEKL-RN--------------------------------------------------QRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPS--------------------------------------TLSTNVNAPTLGAGIDSS--ESPTPIPHIRPSC-TS-DNDN---------GRQSEDCRRVCSPCPLG----------VGGHQNTHHIQSNGHAQGHALVPAISPRLNF--------------------NSGSFGAMYSNMHHTALSMSDSYGAVTPIPSFNHSA-VGPLAPP---------------------------------------------SPIPQQGDLTPSSLYPC----------HMTLRPPP--MAPAHHHIVPGDGGRPA-----------------------------------GVGLGSGQSANLGASCSG-----------------------SGYEVLSAYALPPPPMASSSAADSSFSAASSASANVTPHHTIAQESCPSPCSSASHFGVAHSSGFSSDPISPAVSSYAHMSYNYASSANTMTPSSASGTSAHVAPGKQQFFASCFYSPWV 
 
AMEPPYFIEPLEHVEAAIGEPITLQCKVDGTPEIRIAWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYTCKAENSVGAVASSA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLVIKERKLPPSFAR--KLKDVHETLGFPVAFECR-----INGS-----EPLQVSWYKDGELLKDDANLQ-------------------------TSFIHNVATLQILQTDQSHVGQYNCSASNPLGTASSS----------------------AKLTLSEHEVPPFFDLKPVSVDL--ALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVTKGDAG----------QYTCYASNVAGKDSCSAQ-LGVQEPPRFIKKLEPSRIVKQDEHTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVESVAVLEMYNLSVEDSGDYTCEAHNAAGSASSSTSLK-V--KEPPVFRKKPHPVETLKGADVHLECE----LQGTPPFQ-V------------------------------------------------S--WH-K---DKR-E----LRS--GKK--YKIMSENFLTSIHILNV-------------DSADIGEYQCKA-SN-DVGSD-TCVGSITLKAPPRFVKKLSDISTVVGEEVQLQATIEGAEPIS-VAWFKDKGEIVRESDNIWISYSENIATL-QFSRAEPANAGKYTCQIKNEAGTQECFATLSVLE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ 
------------------------------------------------------------------------------------------MRNLPCLGTAGGSGLGGIAGKPSPTMEAVEASTASHRHSTSSYFATTYYHLTDDECHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNS--SES-----------------GGASNSGEGSEQEAIYEKLRLLNTQHAAGP-----GPLEPARAAPLVGQSPNHLGTRSSHPQLV--HGNHQ--------------------------ALQQHQQQSWPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPP--------------------------NDIES-----LASIGHQRNC----PVATEDIHLKKELD--------GHQSDETGSGEGENSNGGASNIGNT---------------------------------------------------------EDDQAR-----LILKRKLQRNRTSFTNDQI---------------------DSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLS--ACS--SLL----------------SGSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESPTPIPHIRPS--CTSDN-D-NG-RQS------------EDCRRV-C-SP--------CPLGVGGHQNTHHIQSNG---------------------------HAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVTPIPSFNHSAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAPAHHHIVPGDGGRPAGVGLGSGQSANLGASCSGSGYEVLSAYALPPPPMASSSAADSSFSAASSASANVTPHHTIAQESCPSPCSSASHFGVAHSSGFSSDPISPAVSSYAHMSYNYASSANTMTPSSASGTSAHVAPGKQQFFASCFYSPWV 
 
KKL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI------------KNFRDR--PRLPDNYTQDTWRKL-HEAVRAVQSSTSIRYNLEELYQAVENLCSHK-----------------------------VSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLD----------RTYVLQNSTLPSIW-DMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCL-YAAEGQRLMQEREV----PEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGG-----------QQALLQHWSEYIKTF-GTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRL--LV--G-----KSASVDAEKSMLSKLKHECGAAFTSKLEG--------------------MFKDMELSK-DIMV-------------HFKQHM-QNQSD--SGP-IDLTVNILTMGY----WPT-YT-PMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 
---MRNLPCLGTAGGSGLGGIAGKPSPTMEAVEASTASHRHSTSSYFATTYYHLTDDECHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNSSESGGASNSGEGSEQEAIYEKLRLLNTQH-AA------------------------------GPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQ--AL-------------------------------------------------QQHQQQSWPPR---HYSGSWYPTSLSEIPISSA----------------------------------------PNI----A----S--VT--A---YA-------------SGPSLAHSLSP-PN-DIE--S------------L--AS--IGHQ--R---N---CP--V-----------AT-EDIHLKKELDGHQSDETGSGEGE-NSN--G---GA--S--------NIGNTED-DQ-AR--LI---------L---KR--KL---------QR-NRTSFTN-DQI----------------------------DSLEKEFERTHYPDVFARERLAGKIGLPEARIQVW-FSNRRA--------------KWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLS-SPSTLSTNV----NAPTLG-AG-IDS-----------S--ESPT-PIP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HIRPSCTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVTPIPSFNHSAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAPAHHHIVPGDGGRPAGVGLGSGQSANLGASCSGSGYEVLSAYALPPPPMASSSAADSSFSAASSASANVTPHHTIAQESCPSPCSSASHFGVAHSSGFSSDPISPAVSSYAHMSYNYASSANTMTPSSASGTSAHVAPGKQQFFASCFYSPWV 
 
(a)Residue pairs that are structurally aligned by TM-align program are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade.(more about the colors used)
(b)Ranking of proteins is based on TM-score of the structural alignment between Model1 and the PDB structures in our template library.
(c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the model.

  Function Prediction

  Predicted EC Numbers

RankTM-scoreRMSDaIDENaCov.EC-ScorePDB
Hit		EC No.
10.1715 7.87 0.05 0.260.15312e9wB 2.7.10.1
 
20.1745 8.03 0.03 0.260.13803b43A 2.7.11.1
 
30.1776 8.00 0.01 0.260.12692vkzG 2.3.1.383.1.2.14
 
(a)Ranking is based on EC-score, which is a confidence score for the Enzyme Classification (EC) Number prediction.
(b)RMSDa is the RMSD between models and the PDB structure in the structurally aligned regions by TM-align.
(c)IDENa is percentage sequence identity in the structurally aligned region.
(d)Cov. represents the coverage of the alignment and is equal to the number of structurally aligned residues divided by length of model.
(e)EC-Score is defined based on the C-score of the structure prediction and similarity of the model with known enzyme structures, as identified using both global and local structural alignment programs. The global similarity score uses TM-score, IDENa,RMSDa and Cov. of the structural alignment by TM-align, while the local match compares the structural and chemical similarity of local spatial motifs in the model with known catalytic site of enzymes. A prediction with a EC-score >1.1 signifies a prediction with high confidence (upto 3 digit numbers of EC) and vice versa (For details, see Ambrish, Kucukural and Zhang,Large scale benchmarking of protein function prediction using predicted protein structures, 2009, submitted).

  Predicted GO terms

RankTMscoreRMSDaIDENaCov.PDB
Hit		Fh-ScoreAssociated GO Terms
10.9003 1.47 0.06 0.922gsxA 0.88 GO:0001848 GO:0004875 GO:0042802 GO:0042803 GO:0002376 GO:0006955 GO:0009987 GO:0044237 GO:0050789 GO:0065007 GO:0005623 GO:0005886 GO:0016021
20.2495 8.47 0.02 0.392q7zA 0.18 GO:0001848 GO:0004875 GO:0002376 GO:0006955 GO:0009987 GO:0044237 GO:0050789 GO:0065007 GO:0005623 GO:0005886 GO:0005887 GO:0016021
30.2159 8.14 0.03 0.322qzvB 0.17 GO:0005515 GO:0005622 GO:0005623 GO:0005737 GO:0030529
40.1965 9.04 0.03 0.321sjjB 0.16 GO:0003779 GO:0005509 GO:0043169 GO:0005622 GO:0005623 GO:0005737 GO:0005856 GO:0043229
50.1775 8.82 0.04 0.281xi5I 0.15 GO:0005198 GO:0005515 GO:0006886 GO:0009987 GO:0016192 GO:0034613 GO:0046907 GO:0051641 GO:0051649 GO:0000139 GO:0005622 GO:0005623 GO:0005737 GO:0005739 GO:0005794 GO:0005886 GO:0005905 GO:0012505 GO:0030125 GO:0030130 GO:0030132 GO:0030133 GO:0030136 GO:0030140 GO:0030660 GO:0030665 GO:0031410 GO:0042470 GO:0043229 GO:0044433 GO:0044444 GO:0048475
60.1643 7.45 0.05 0.242pfvA 0.14 GO:0005515 GO:0005546 GO:0000282 GO:0000910 GO:0006887 GO:0006893 GO:0006904 GO:0006906 GO:0006944 GO:0007105 GO:0007121 GO:0009653 GO:0015031 GO:0016050 GO:0019954 GO:0022406 GO:0032940 GO:0046907 GO:0048284 GO:0048856 GO:0051641 GO:0051649 GO:0000145 GO:0005622 GO:0005623 GO:0005737 GO:0005933 GO:0005935 GO:0005938 GO:0044448
70.1728 7.65 0.04 0.251q5cD 0.14 GO:0005509 GO:0005515 GO:0043169 GO:0007156 GO:0022610 GO:0005623 GO:0005886 GO:0016021
80.1745 8.03 0.03 0.263b43A 0.14 GO:0000287 GO:0004674 GO:0005085 GO:0005089 GO:0005509 GO:0005516 GO:0005524 GO:0008307 GO:0016301 GO:0030554 GO:0031433 GO:0042301 GO:0043169 GO:0043621 GO:0051015 GO:0051393 GO:0000087 GO:0000278 GO:0003007 GO:0006323 GO:0006461 GO:0006468 GO:0006941 GO:0007015 GO:0007067 GO:0007076 GO:0007154 GO:0007507 GO:0007517 GO:0010926 GO:0010927 GO:0016310 GO:0022607 GO:0030029 GO:0030240 GO:0030241 GO:0030261 GO:0031032 GO:0031034 GO:0034960 GO:0035023 GO:0043412 GO:0045214 GO:0045859 GO:0048468 GO:0048646 GO:0048739 GO:0048856 GO:0051592 GO:0055003 GO:0055008 GO:0055013 GO:0070271 GO:0000793 GO:0000794 GO:0005622 GO:0005623 GO:0005634 GO:0005737 GO:0030016 GO:0030018 GO:0031674 GO:0043229
90.1612 8.23 0.04 0.251zlgA 0.14 GO:0004867 GO:0005201 GO:0005515 GO:0000904 GO:0006928 GO:0006935 GO:0007005 GO:0007155 GO:0007411 GO:0007626 GO:0009653 GO:0022610 GO:0030030 GO:0040011 GO:0042221 GO:0048468 GO:0048667 GO:0048856 GO:0048858 GO:0070584 GO:0005576 GO:0005578 GO:0005615 GO:0005623 GO:0009986
100.1533 7.99 0.05 0.232q3zA 0.14 GO:0003810 GO:0005509 GO:0005525 GO:0008415 GO:0019001 GO:0019904 GO:0043169 GO:0006950 GO:0007154 GO:0007155 GO:0007275 GO:0008283 GO:0009653 GO:0010926 GO:0016043 GO:0016265 GO:0019725 GO:0022610 GO:0043170 GO:0044085 GO:0044237 GO:0048518 GO:0048583 GO:0048771 GO:0050793 GO:0050794 GO:0065009 GO:0005622 GO:0005623 GO:0005737 GO:0005739 GO:0005886 GO:0043229 GO:0044444

Consensus Prediction of Gene Ontology terms 
Molecular Function  Biological Process Cellular Location
GO termGO-Score  GO termGO-Score GO termGO-Score
GO:00054880.226  GO:00099870.219  GO:00056230.226
GO:00055150.226  GO:00069550.213  GO:00444640.226
GO:00048710.107  GO:00442370.161  GO:00160200.150
GO:00048720.107  GO:00081520.161  GO:00058860.150
GO:00048750.107  GO:00508960.161  GO:00444250.136
GO:00048880.107  GO:00507890.148  GO:00312240.121
GO:00600890.107  GO:00650070.148  GO:00160210.121
GO:00018480.107  GO:00023760.107  GO:00057370.091
GO:00428020.088  GO:00325020.069  GO:00056220.091
GO:00428030.088  GO:00160430.069  GO:00444240.091

(a)Ranking in the first table is based on a function prediction score (Fh-score), which is calculated based on the C-score of the structure prediction and the TM-score, IDENa, RMSDa and Cov. of the structural alignment by TM-align between the predicted model and the PDB structures (For details, see Ambrish, Kucukural and Zhang,Large scale benchmarking of protein function prediction using predicted protein structures, 2009, submitted).
(b)RMSDa is the RMSD between models and the PDB structure in the structurally aligned regions by TM-align.
(c)IDENa is the percentage sequence identity in the structurally aligned region.
(d)Cov. represents the coverage of the alignment and is equal to the number of structurally aligned residues divided by length of model.
(e)A consensus prediction of GO terms is derived from the structural analogs that have an Fh-score of >=1.0. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on the Fh-score of the template from which the GO term is derived. A prediction with a GO-score >0.5 signifies a prediction with high confidence and vice versa.


  Predicted Binding Site


Binding site residues in the model:
PRO:354  LEU:356  ALA:357  HIS:358  SER:359  LEU:360  HIS:374  
GLN:375  ARG:376  ASN:377  CYS:378  PRO:379  VAL:380  ALA:381  
THR:382  GLU:383  LEU:387  GLY:402  
Identified analogs with similar binding site:

RankPDB
Hit		TM-scoreRMSDaIDENaCov.BS-scoreDownload
Complex		Binding site residues on the predicted model
12cg9B0.1514 7.85 0.03 0.22 0.03Download354,356,357,358,359,360,374,375,376,377,378,379,380,381,382,383,387,402

(a)Ranking of the analogs in the table is based on their BS-score. BS-score is calculated by first finding the structural analogs of the predicted model based on their TM-score, IDENa and Cov. of the structural alignment. The ligand(s) in the analog structure are then transferred onto the model and the fitness of the ligand-model complex (BS-score) is calculated by comparing the local structure and sequence similarity in the binding site region. (For detail, see Kucukural, Szilagyi, Ambrish, and Zhang, Template based ligand binding site prediction on modeled protein structure, 2009, in preparation).
(b) A BS-score of >0.5 signifies a binding site prediction with high confidence and vice-versa.
(c)RMSDa the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the model.
(f)The image shows the ligand-protein complex with the best BS-score. The ligand is depicted in magenta colored ball & stick, the predicted binding site residues interacting with the ligand are shown as transparent green spheres, while the N & C terminus in the model are marked by blue and red spheres respectively.



 Please cite following articles when you use the I-TASSER server:
1.Yang Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9:40 (2008).
2.Yang Zhang. Template-based modeling and free modeling by I-TASSER in CASP7. Proteins, 8: 108-117 (2007).
3.Sitao Wu, Jeffrey Skolnick, Yang Zhang. Ab initio modeling of small proteins by iterative TASSER simulations. BMC Biology, 5:17 (2007).