TM-score FAQ

  • Q: There are mismatches when I compare my model with PDB files.
  • A: TM-score only compare the common regions where both model and PDB structure have avaliable coordinates. The common regions are decided by the residue sequence number (Column 23-26 in PDB format). It is user's responsibility to keep the equivalence of compared residues in both pdb files.

  • Q: Can I specify the chain identifier?
  • A: No. TM-score automatically reads all C-alpha coordinates from input files. Users usually should re-edit the orginally PDB file and keep only the compared residues in the PDB files before runing TM-score.

  • Q: When I run TMscore in my local machine, I get a warning message: "bash: ./TMscore: cannot execute binary file".
  • A: You need to download another compiled version.


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