Yang Zhang |
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Research Interests
Research Highlights - Performance in CASP7Critical Assessment of Structure Prediction (CASP) is a biennial worldwide competition in protein structure prediction, which has also been called Olympic games of protein structure prediction. The organizer releases a number of amino acid sequences whose structure is unknown to the predictors. The structures predicted by the participants have to be submitted before a deadline. Finally, the predicted structures are compared by an independent team with the structures solved by X-ray or NMR experiments.The 7th CASP competition was held in 2006, which included Human and Server sections. Depending on modeling difficulty, the targets were split into 3 categories: HA (easy), TBM (medium), and FM (hard) targets. Our lab participated in the CASP7 experiment as "Zhang" in the Human section and as "Zhang-Server" in the Server section; both were ranked as the No 1 according to the accumulative GDT-TS score of all targets. The table lists the accumulative GDT_TS scores of the top-10 groups ranked by the first model in each category. A name with "*" indicates a server predictor.
The picture shows a histogram of Z-score of the GDT-TS score of all groups in the CASP7 Server Section.
The following picture shows one of the successful examples from the target T0382 from Rhodopseudomonas Palustris CGA009 crystallized by the structure genomics project. I-TASSER starts from the template structures which are more than 9 Angstroms away from the native structure (left panel) and builds a model of 3.6 Angstroms (right panel).
More detailed data of the automated assessments of the CASP7 results can be seen at here, or at the webpages by other groups: [BioInfoBank] [CAFASP5] [McGufin] [Offman] [Robetta] [SBC]
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